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FUB8

Gene
FUB8
Protein
Non-canonical non-ribosomal peptide synthetase FUB8
Organism
Gibberella moniliformis (strain M3125 / FGSC 7600)
Length
1058 amino acids
Function
Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
Mass
117.641 kDa
Sequence
MQKIAKQALSSLSSLAKSPANAMGSISHLPAYGHRLLPVLIDEISRDEPDRVLFYTPRNGQPSQGYDEVTTKIFANAIDRLCGWLDSQLGSPTVSKTIAYIGQNDLRYFIIMIASTKLGHRLLLSSPRNSVEGHVSLIKQSGCELWIASSGLGHHEFLQDLHIPSVEAPELSELLDPTLAKPYIYQKSWHEGKSDVLALLHTSGSTGLPKLVPVYLETAATVDGFHLMEPTDGKRPTGVEWTGTRQLCAMPLFHVAGICLGLYSAVFFNWIVVLPSVGPIMQHVIEDALDHISLDSAFISPSVLQDISKSSRVLEKLSKLKFITSAGGPIPQSVGDLIHPRVPIMQTMGMTEGQWLASVVMHPDEWAYYYFHPRTGVEMRPYSEDLFELVFVQNPKLSATQPVFKTFPDLDIWETKDLYSRHPKHPDLWKYEMRRDDLIILSNGEKFNPLAAEGKLISHPWIAAAYLTGRGRFQTAALIYPDDSSFNNSDDTIIDNIWPTFEEVNKSLPAFAQIHRDFVKIVRTPFPCTPKGTLARNETEKSFNADINAIYDRSTHGKPSVHINGTTEDVVRSGIREAIETVSGLVDLKDDDNIFTRGFDSLHVIRLAGLLSSAFYQPLEVEPGTIYTNPTISQLSHSVWTHLEYGPQDRIHHSEVTLEMLAKYIQAFEPPRESKEHIVLTGTTGEIGSYLLDDICKNDKVAKVWCLNRSVDAFQRQVDSAKSKGLSSNWQSKAKFVRYDVTSENLGLSQDDLEEIKNEATAIIHNAWEVNFNLPLSSFDPQFVGLQGLVDVCRATRHKIRFFFVSSISAAMNWPSDLLGPVPEASISRFDAPINGYGSSKLVAEHLLSKAARSGVLSLSVLRVGQVAGPVRTLGEGSIWTRRDWVPAIIDASVHLRALPLDLGSASILDWIPIDLLAEVIGQLVVPVNPVVGQENYYNLLNPRTPSWKDTLPGLKAHLEASFSEKFEIIPLQEWINRMRGAEKTIVKEVSEGSSETARRAQSGLKLLAFFETLASETEGSRGLEWSKANALAQSSILACMEPVSSAWFDTWLTQWGY

Gene
FUB8
Protein
Non-canonical non-ribosomal peptide synthetase FUB8
Organism
Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)
Length
1036 amino acids
Function
Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
Mass
115.084 kDa
Sequence
MGSISHLPAYGHRLLPVLIDEIARDEPDRVLFYTPRNGQPSQGYDEVNTKIFANSINRLCGWLDSQLGSPAGPRTIAYIGQNDLRYFIMMIASTKLGHRLLLSSPRNSVEGHVSLIKQSGCEFWIASSGLDHHEFLQDLQIPSVEAPELPQLLDPTPVKPYVYQKSWNEGKSDVLALLHTSGSTGLPKLVPVYLETAATVDGFHLMEPTNGKRPTGVEWTGTRQLCAMPLFHVAGICLGLYSAVFFNWTVVLPSVGPIMQHVIEDALDHISLDSAFISPSVLQDISKSPRVLEKLSKLKFITSAGGPIPQSVGDLIHPRVPIMQTMGMTEGQWLASVVTHPDEWAYYYFHPRTGVEMRPYSEDLSELVFVQNPKLSATQPVFKTFPELDIWETKDLYSRHPKHPDLWKYEMRRDDLIILSNGEKFNPLAAEGKLISHPWIAAAYLTGRGRFQTAALLYPDENSLDKSDDIITDNVWPTFEEVNKSLPAFAQIHRDFVKIVRTPFPRTPKGTLARNETEKAFTADINAIYDRSTHGKPSVHINGTTEDVVRSGIREAIETVSGLVDLKDDDNIFTRGFDSLHVIRLAGLLSSAFDQPLEVEAGTIYTNPTISQLAHTVWSHLEHGPQDKVHHSEVTREMLAKYAQAFEPPREAKEHIVLTGTTGEIGSYLLDVLCNNDKVAKVWCLNRSADAFQRQVDSAKSKGLSSSWKSKAKFVRYDVASENLGLSQDGLEEIKNEATAIIHNAWEVNFNLPLSSFEPQFIGLKSLVDVCRESRQKIRFFFVSSISAAMNWPSDLLGPVPEASIPRFDAPINGYGSSKLVAEHLLSKAARSGVLSLSILRVGQVAGPVKTLGEGSIWTRRDWVPAIIDASAHLRALPLDLGSASILDWIPIDLLTEVIGQLVVPVNPVVGQENYYNLLNPRTPSWTDSLPGLKARLEASFSDTFEIIPLQEWISRLRGAEKTIVKEVSEGSSETAIRAQSGLKLLAFFEMLASGKEGSRGLEWAKANTLAQSSFLACMEPVSSAWFDTWLKQWGY

Gene
FUB8
Protein
Non-canonical non-ribosomal peptide synthetase FUB8
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
1036 amino acids
Function
Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).
Mass
115.068 kDa
Sequence
MGSISHLPVYGHRLLPVVIDEIARDEPDRVLFYTPRNGQPSQGYDKVTTKIFANSINRLCGWLDSQLGSPTVSKTIAYIGQNDLRYFIMMIASTKLGHRLLLSSPRNSVEGHVSLIKQSGCEFWIASSGLDHHGFLQDLQIPSVEAPELSQLLDPTPLKPYVYQKSWNEGKSDILALLHTSGSTGLPKLVPVYLETAATVDGFHLMELTNGKRPTGVEWTGTRQLCAMPLFHVAGICLGLYSAVFFNWTVVLPSVGPIMQHVIEDALDHITLDSAFISPSVLQDISKSPRVLEKLSKLKFITSAGGPIPQSVGDLIHPRVPIMQTMGMTEGQWLASVVTHPDEWAYYYFHPRTGVEMRPYSEDLSELVFVQNPKLTATQPVFKTFPELDIWETKDLYSRHPKHPSLWKYEMRRDDLVILSNGEKFNPLAAEGKLISHPWIAAAYLTGRGRFQTAALLYPDETNLDKSDDTIIDNVWPTFEEVNRSLPAFAQIHRDFVKIVRTPFPRTPKGTLARNETEKAFTADINAIYDRSTHGKPSVHINGTTEVVVRSGIREAIEAVSGLVDLKDDDNIFTRGFDSLHVIRLAGLLSSAFDQPIEVEVGTIYTNPTVSQLARSVWSHLEHGPQDKIHHSEATREMLAKYAQAFEPPREAKEHIVITGTTGEIGSYLLDVLCNNDKVAKIWCLNRSADAFQRQVDSAKSKGLSSTWQSKAKFVRYDVAADNLGLSQDDLQEIKNQATAIIHNAWEVNFNLPLSSFEPQFVGLQSLVDICREARHKLRFFFISSISAAMNWPSDLLGPVPEASIPRFDAPINGYGSSKLVAEHLLSKAARSGVLSLSVLRVGQVAGPVKTLGEGSIWTRRDWVPAIIDASVHLRALPLDLGTASILDWIPIDLLTEVIGQLVVPVNAVVGQENYYNLLNPRTPSWIDALPGLKAHLEVSFSDKFEIIPLHEWIGRLRGAEKTIVKEVSEGSSETARRAQSGLKLLAFFEMLASGEEGSRGLEWSKGNTLAQSSILACMEPVSSAWFGTWLTQWGY

Gene
FUB8
Protein
Oxidase FUB9
Organism
Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)
Length
387 amino acids
Function
Oxidase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
Similarity
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Mass
41.274 kDa
Sequence
MSRTNLPIQPAKMSDATSSKPQIFSIQDLKQAASDKMSQMYRDYYNGGAMDNITLASNEAAFDRYLLRPRVLRNVSNIDMTTTLWGTKAALPLGVSPSAMHRLAHADGEVGTSKACAARNVPMILSALSNDTLEDVSGQSSDGSTPYAIQVSPFKNRQITTNLLSRAKAAGYKAVVLTVDAPMFGRRLDDLRNGFSIPPGFSFPNLSAQTQSGSGGLGGGIPDLSFDTAATWEEKIAWMKSQTDLEIWVKGVTSPLDAQIAIEQGVDGIIISNHGGRQLDTTPATIDILREIAPIAKGKTRIAIDGGFRRGSDIFKAVALGADFVFVGRIAIWGLAYDGSNGVGLALDLLINEFKLCMGLAGCSKISDITPAHLSILNAKGVLESVY