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FSL7

Gene
FSL7
Protein
Fusarielin biosynthesis cluster transcription factor FSL7
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
496 amino acids
Function
Transcription regulator that specifically up-regulates the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016). Probably binds the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes (PubMed:22252016).
Mass
54.157 kDa
Sequence
MSQPCKDSDAKLRAACDRCHELKIRCTRTGGTESRCDRCEKNDIDCVYRAHRRIGRPKSQKSRCGPNTTARQNDTTTRGRIQQEQQEQMDISPPENRDSINSDFDFSIFEASGAVEWHRSSDVINVSTHQVSSTHPPFISPDCSLSHESSMSQTGSGSPFSMLNIGTMPVCDLDLSTLHGYGPSTDLVRSINHRSGSENESMEGNAELQSTQSASGSPQEEDQMLEDRLLRHQAKLRCLYSTVDATRNLISTTNDTVSHGAPLDKVLEAIMELVEILQTNANHTSSSSSSNSTTVDGPSEIRNQSRSRQDIANFNDIAILHVSISYAYIVKILAPIILSLEKSSVPVGSTSSSTYNDTTAHPSSASLPSQTGGPTKPRTVSVSLGSFSLASKPALNAQILLGMISRMLDQLHDATQPILMQVRHHHVPTQPVALQEREHHDAAMTREQHVSTGHGPDRHTSPVLSSAQAAVDSIRNEEKELLAKLNKVGNSTSATW