Protein
Follicle-stimulating hormone receptor
Function
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase (PubMed:10527886, PubMed:9364440). Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase (PubMed:10527886, PubMed:9364440). Isoform FSH-R3 may be involved in calcium signaling (PubMed:10527886). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Sequence
MALFLVALLAFLSLGSGCHHRLCHCSNGVFLCQDSKVTEMPSDLPRDAVELRFVLTKLRVIPEGAFSGFGDLEKIEISQNDVLEVIEANVFSNLPKLHEIRIEKANNLLYIDPDAFQNLPNLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHTVERNSFMGLSFESMIVWLSKNGIQEIHNCAFNGTQLDELNLSDNSNLEELPNDVFQGASGPVILDISRTRIRSLPSYGLENLKKLRAKSTYHLKKLPSLEKFVTLVEASLTYPSHCCAFANWRRQTSDLHPICNKSILRQEVDDMTQARGQRISLAEDDEPSYAKGFDMMYSEFDYDLCSEVVDVTCSPEPDAFNPCEDIMGYDILRVLIWFISILAITGNILVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDVHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVHVRHAASIMLVGWVFAFAVALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNITSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPINSCANPFLYAIFTRNFRRDFFILLSKFGCYEVQAQTYRSETSFTAHNFHPRNGHCPPAPRVTNGSNYTLIPLRHLAKN