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FOXJ1

Gene
foxj1
Protein
Forkhead box protein J1
Organism
Xenopus tropicalis
Length
438 amino acids
Function
Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function.
Similarity
Belongs to the FOXJ1 family.
Mass
48.947 kDa
Sequence
MFDLPTVAPIDMEDSWVTFQAEGEQGQDSFSSSVNLDDSLTSLQWLQEFSILNANVGKAPSSGDSHGYKHLFGAPCSPLAADPACLGMPHTPGKPISSSTSRASHLGLQPMEDIDYKTNPHVKPPYSYATLICMAMQASKKTKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWKIDPQYADRLMNGAMKKRRLPPVQIHPAFASAQAAASGNSNRGSPWQLSVNSESHQLLKEFEEATGEQGWNALGEHGWNAISDGKSHKRKQPLPKRMFKAPRLSSSPMLCQEEQTELGSLKGDFDWEVIFDSSMNGVNFSAFEDLEVTPPLSPVTRSVDLTVHGKHIDCPQQWYPLGQDQAVVQNSLDFDETFLATSFLQHPWEENRNDYLSNSANIEQLFDLNEEFPAELNDWSALGSYI

Gene
FOXJ1
Protein
Forkhead box protein J1
Organism
Homo sapiens
Length
421 amino acids
Function
Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Similarity
Belongs to the FOXJ1 family.
Mass
45.247 kDa
Sequence
MAESWLRLSGAGPAEEAGPEGGLEEPDALDDSLTSLQWLQEFSILNAKAPALPPGGTDPHGYHQVPGSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSAVPRAGPLTVNTEAQQLLREFEEATGEAGWGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGGELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPLFEAGDATLASDLQDWASVGAFL

Gene
Foxj1
Protein
Forkhead box protein J1
Organism
Mus musculus
Length
421 amino acids
Function
Transcription factor specifically required for the formation of motile cilia (PubMed:9096351, PubMed:9739041, PubMed:10873152, PubMed:14996907, PubMed:22357932, PubMed:27965440). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157 (PubMed:27965440). Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T) (PubMed:9096351). Activates the transcription of a variety of ciliary proteins in the developing brain and lung (PubMed:28666954, PubMed:27914912).
Similarity
Belongs to the FOXJ1 family.
Mass
45.474 kDa
Sequence
MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSILNAKAPTLPPGGTDPHGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQASQEPSAAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQPLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSPPLSPSSHGDVDLTVHGRHINCPATWGPPAEQAADSLDFDETFLATSFLQHPWDESGSGCLPPEPIFEAGDATLAADLQDWASVGAFL

Gene
Foxj1
Protein
Forkhead box protein J1
Organism
Rattus norvegicus
Length
421 amino acids
Function
Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung.
Similarity
Belongs to the FOXJ1 family.
Mass
45.566 kDa
Sequence
MAESWLRLCGAGPGEEAGPEGGMEEPDALDDSLTSLQWLQEFSILNAKAPTLPPGGTDPLGYHQVPGLVAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLICMAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWRIDPQYAERLLSGAFKKRRLPPVHIHPAFARQAAQEPSTAPWGGPLTVNREAQQLLQEFEEATGEGGWGTGEGRLGHKRKQPLPKRVAKVLRPPSTLLLTQEEQGELEPLKGNFDWEAIFEAGALGEELSSLEGLELSPPLSPSSHGEVDLTVHGRHINCPATWGPPVEQATDSLDFDETFLATSFLQHPWDESSSGCLPPEPLFEAGDATLAADLQDWASVGAFL