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FOS

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Cricetulus griseus
Length
381 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.998 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCADLSGSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAAMVKTVSGGRAQSISRRSKVEQLSPEEEEKRRIRRERNKMAAAKCWNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEATTPESEEAFSLPLLNDAEPKTSLEPVKSISNMELKAEPFDDFLFPPSSRPSGSETTARSVPDMDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Felis catus
Length
381 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.721 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDNLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPAPSAGAYSRAGVVKTVTAGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKAEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHGGSLGMGPMATELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCGAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Mesocricetus auratus
Length
381 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
41.02 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSTGAYSRAGMVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMFVASLDLTGGLPEATTPESEEAFSLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETTARSVPDMDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Phodopus campbelli
Length
381 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.957 kDa
Sequence
MMFSGFNAEYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPPTGAYSRAGMVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDHLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEDMSVASLDLTGGLPEATTPESEEAFSLPLLNDPEPKTSLEPVKSISNMELKAEPFDDFLFPASSRPSGSETTARSVPDMDLSGSFYAADWEPLHSSSLGMGPMATELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Phodopus roborovskii
Length
381 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.92 kDa
Sequence
MMFSGFNTDYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSTGAYSRAGMVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEDMSVASLDLTGGLPEAATPESEEAFSLPLLNEPEPKTSLESVKSISSMELKAEPFDDFLFSASSRPSGSETTARSVPDMDLSGSFYAADWEPLHSSSLGMGPMATELEPLCTPVVTCTPSCTTYTSSFVFTYPETDSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Bos taurus
Length
380 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.737 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDYCTDLAVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAGVMKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSVEPVKSVGSMELKAEPFDDYMFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHGGSLGMGPMATELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Homo sapiens
Length
380 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.695 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
Fos
Protein
Proto-oncogene c-Fos
Organism
Mus musculus
Length
380 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.838 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTQSAGAYARAGMVKTVSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEASTPESEEAFTLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYAADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Sus scrofa
Length
380 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.674 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSVNFIPTVTAISISPDLQWLVQPTLVSSVAPSQTRAPHPYGVPTPSAGAYSRAGAVKTMPGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSVEPVKKVSSMELKAEPFDDFLFPASSRPGGSETARSVPDMDLSGSFYAADWEPLHGGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
Fos
Protein
Proto-oncogene c-Fos
Organism
Rattus norvegicus
Length
380 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.927 kDa
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPNDLGFPEEMSVTSLDLTGGLPEATTPESEEAFTLPLLNDPEPKPSLEPVKNISNMELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFYAADWEPLHSSSLGMGPMVTELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
fos
Protein
Proto-oncogene c-Fos
Organism
Takifugu rubripes
Length
376 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.826 kDa
Sequence
MMFTSFNAECDSSSRCSASPVGDNLYYPSPAGSYSSMGSPQSQDFTDLTASSASFIPTVTAISTSPDLQWMVQPLISSVAPSHRAHPYSPSPSYKRTVMRSAASKAHGKRSRVEQTTPEEEEKKRIRRERNKQAAAKCRNRRRELTDTLQAETDQLEDEKSSLQNDIANLLKEKERLEFILAAHQPICKIPSQMDTDFSVVSMSPVHACLSTTVSTQLQTSIPEATTVTSSHSTFTSTSNSIFSGSSDSLLSTATVSNSVVKMTDLDSSVLEESLDLLAKTEAETARSVPDVNLSNSLFAAQDWEPLHATISSSDFEPLCTPVVTCTPACTTLTSSFVFTFPEAETFPTCGVAHRRRSNSNDQSSDSLSSPTLLAL

Gene
fos
Protein
Proto-oncogene c-Fos
Organism
Takifugu rubripes
Length
376 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.826 kDa
Sequence
MMFTSFNAECDSSSRCSASPVGDNLYYPSPAGSYSSMGSPQSQDFTDLTASSASFIPTVTAISTSPDLQWMVQPLISSVAPSHRAHPYSPSPSYKRTVMRSAASKAHGKRSRVEQTTPEEEEKKRIRRERNKQAAAKCRNRRRELTDTLQAETDQLEDEKSSLQNDIANLLKEKERLEFILAAHQPICKIPSQMDTDFSVVSMSPVHACLSTTVSTQLQTSIPEATTVTSSHSTFTSTSNSIFSGSSDSLLSTATVSNSVVKMTDLDSSVLEESLDLLAKTEAETARSVPDVNLSNSLFAAQDWEPLHATISSSDFEPLCTPVVTCTPACTTLTSSFVFTFPEAETFPTCGVAHRRRSNSNDQSSDSLSSPTLLAL

Gene
fos
Protein
Proto-oncogene c-Fos
Organism
Tetraodon fluviatilis
Length
374 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.526 kDa
Sequence
MMFTSFNAECDSSSRCSASPSDNVYYPSPAGSYSSMGSPQSQDLTDLTASSASFVPTVTAISTSPDLQWMVQPLVSSVAPSRRAHPYSPSPSYKRTVMRSGASKPHAKRGRVEQTTPEEEEKKRIRRERNKQAAAKCRNRRRELTDSLQAETDQLEAEKSSLQNDIANLLKEKERLEFILAAHQPICKIPSQMDSDFPVVSMSPVHAYLSTAASTQPQTSVPEATTVTSSHSTFTSTSNSIFGSNSDSLLSTATVSDSVVKMTDLESSVLEESLDLLAKTEVETVEVPDVNLSSSLYTAQDWEPLHATIGSSDFEPLCTPVVTCTPACTTITSSFVFTFPEAETFPTCCVAHRRGSNSNDQSSDSLSSPTLLAL

Gene
fos
Protein
Proto-oncogene c-Fos
Organism
Tetraodon fluviatilis
Length
374 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
40.526 kDa
Sequence
MMFTSFNAECDSSSRCSASPSDNVYYPSPAGSYSSMGSPQSQDLTDLTASSASFVPTVTAISTSPDLQWMVQPLVSSVAPSRRAHPYSPSPSYKRTVMRSGASKPHAKRGRVEQTTPEEEEKKRIRRERNKQAAAKCRNRRRELTDSLQAETDQLEAEKSSLQNDIANLLKEKERLEFILAAHQPICKIPSQMDSDFPVVSMSPVHAYLSTAASTQPQTSVPEATTVTSSHSTFTSTSNSIFGSNSDSLLSTATVSDSVVKMTDLESSVLEESLDLLAKTEVETVEVPDVNLSSSLYTAQDWEPLHATIGSSDFEPLCTPVVTCTPACTTITSSFVFTFPEAETFPTCCVAHRRGSNSNDQSSDSLSSPTLLAL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Gallus gallus
Length
367 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
39.005 kDa
Sequence
MMYQGFAGEYEAPSSRCSSASPAGDSLTYYPSPADSFSSMGSPVNSQDFCTDLAVSSANFVPTVTAISTSPDLQWLVQPTLISSVAPSQNRGHPYGVPAPAPPAAYSRPAVLKAPGGRGQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEEEKSALQAEIANLLKEKEKLEFILAAHRPACKMPEELRFSEELAAATALDLGAPSPAAAEEAFALPLMTEAPPAVPPKEPSGSGLELKAEPFDELLFSAGPREASRSVPDMDLPGASSFYASDWEPLGAGSGGELEPLCTPVVTCTPCPSTYTSTFVFTYPEADAFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL

Gene
fos
Protein
Proto-oncogene c-Fos
Organism
Cyprinus carpio
Length
347 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
37.587 kDa
Sequence
MMFTSLNADCDASSRCSTASAAAESVACYPLNQTQKFTELSVSSASFVPTVTAISSCPDLQWMVQPMVSSVAPSNGGARSYNPNPYPKMRVTGTKSPNSNKRARAEQLSPEEEEKKRVRRERNKMAAAKCRNRRRELTDTLQAETDELEDEKSALQNDIANLLKEKERLEFILAAHKPICKIPSSSVSPIPAASVPEIHSITTSVVSTANAPVTTSSSSSLFSSTASTDSFGSTVEISDLEPTLEESLELLAKAELETARSVPDVDLSSSLYARDWESLYTPANNDLEPLCTPVVTRTPACTTYTSSFTFTYPENDVFPSCGPVHRRGSSSNDQSSDSLNSPTLLTL

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Ovis aries
Length
195 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
21.255 kDa
Fragment
single
Sequence
ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYAADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTS

Gene
FOS
Protein
Proto-oncogene c-Fos
Organism
Ovis aries
Length
195 amino acids
Function
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).
Similarity
Belongs to the bZIP family. Fos subfamily.
Mass
21.255 kDa
Fragment
single
Sequence
ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLSGGLPEAATPESEEAFTLPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYAADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTS