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FLU1

Gene
FLU1
Protein
Major facilitator superfamily multidrug transporter FLU1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
610 amino acids
Function
Major facilitator superfamily transporter that mediates resistance to structurally and functionally unrelated compounds including cycloheximide but also azoles such as fuconazole, ketoconazole and itraconazole (PubMed:11065353, PubMed:11181345). Mediates also efflux of histatin 5, a salivary human antimicrobial peptide, and is responsible for reduction of its toxicity in C.albicans (PubMed:23380720, PubMed:28953977).
Similarity
Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
Mass
67.607 kDa
Sequence
MNNNTNSNHNDIAPEATITQNTTTSVSNDELQHITNNNNVNVQSYVGPTDSVESSSNTADEENEINSFNAQNVKDYEANVGGELPPDDELSRIESNTELSRRATRSIMNTESLLRTASQSSKPLPPMGGGKEYPPMLGSRDPYVVAFDGPDDPDHPHNYPTWKKILYCASVGLAALSVSMGSAMFSQASADIMQIYHIGWTPATLTTSLFVFGFASGPVIYGPLSELFGRKLVMVPSCLGYVCFSFAVATAKDIQTIMICRFFAGFIGAAPLVVAPAVMADMFNNRYRGTAIAIFSMLLFGGPMLAPILGAFTVKNSALGWRWTSYFCGIIGSLALFMNTFLLQETHHPLILTRRAEELRRRTGNWGIYAPHEELKLSMKEIVENNIARPLKMLFTEPILFLVSLYNAFIYGMLYLFLTAIPLIFLGEYHFVQGVAELPYLAMLIGILIGGGMIMLFEKRYIKAMEDNGGKIIPEKRLEPMMVGGFTFVIGIFWLGWTGNYPQHVHWIVPVIGAAFVGNGLMLIFLPCFNYIIDCYLLYAATALAGNTFIRSAFGAVFPLFARQMFTNLTIKWASTLLGCIGILLLPMPFVFYYYGKSLRHKSKFAFVLE