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FIS1

Gene
FIS1
Protein
Probable aldehyde dehydrogenase
Organism
Linum usitatissimum
Length
551 amino acids
Function
Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.
Similarity
Belongs to the aldehyde dehydrogenase family.
Mass
61.032 kDa
Sequence
MYRPLVARLLRDSVATRKGSSHFARRFSHSLPFATVDAEELSGAKPAEVLNLVQGNWGGSSSWHTVVDPLNGEPFIKVAEVDETEIKPFVESLSKCPKHGLHNPFKSPERYLLYGDISTKAGHMLSIPKVSEFFARLIQRVAPKSYHQALGEVQVTQKFFENFTGDQVRFLARSFGVPGNHLGQQSNGFRWPFGPVAIITPFNFPLEIPVLQLMGALYMGNKPLLKVDSKVSIVMEQMMRLLHYCGLPVGDADFVNSDGKAMNKILLEANPRMTLFTGSSRVAEKLALDLKGRIKLEDAGFDWKILGPDVNEADYVAWVCDQDAYACSGQKCSAQSILFMHENWAATPLISRLKELAERRKLEDLTVGPVLTVTTEAMLDHLNKLLQIPGAKLLFGGKPLENHTIPSIYGAVKPTAVYVPLEEILKVSNYELVTKEIFGPFQVVTEYKNSQLPMVLEALERMHAHLTAAVVSNDQLFLQEVIGNTVNGTTYAGLRARTTGAPQNHWFGPAGDPRGAGIGTPEAIKLVWSCHREIIYDIGPVSHHWEIPPST

Gene
fis1
Protein
Mitochondrial fission 1 protein
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
160 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
18.329 kDa
Sequence
MTEKHTLRLADPSAIDSIISVDEFLQIKEQYDAEQPLITLQTKFNLAWALVRSDSTQHVQQGLSLFCSIYKDSPERRLECLYYIALSHYKLKQYEESRRYLNMLLSKDPNSPEALKLKNRLYDAVTKEGYIGMVVVAGAVVSVAALVGWASKRLFSKRRP

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
155 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
17.538 kDa
Sequence
MTNIHYLPELEDSYSALNSDQIEILRQQVLNEGGEISSIQSRFNYAWGLVRSTNKEDQMLGVKLLTDIYKESPMRRRECLYYLTIGCYKLGEYSTAKRYVDALVHHEPENKQALMLQTAVENKITSQGLKGIALISAGIAIGATTIGLLIRGRRR

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Tuber borchii
Length
155 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
17.596 kDa
Sequence
MPSDNLPHAVDAESPLKEAELQVLRNQYEKEGQFVGVQTKFNYAWGLIKSDKRPEQQMGVRLLTDIFRDHTERRRECLYYLALGNYKLGNYAEARRYNDRLLENEPANLQSQSLRGLIDDKVAKEGMLGVAIISGVALAAGLVGSALWRGMSRRR

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
155 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division.
Similarity
Belongs to the FIS1 family.
Mass
17.733 kDa
Sequence
MTKVDFWPTLKDAYEPLYPQQLEILRQQVVSEGGPTATIQSRFNYAWGLIKSTDVNDERLGVKILTDIYKEAESRRRECLYYLTIGCYKLGEYSMAKRYVDTLFEHERNNKQVGALKSMVEDKIQKETLKGVVVAGGVLAGAVAVASFFLRNKRR

Gene
Fis1
Protein
Mitochondrial fission 1 protein
Organism
Drosophila melanogaster
Length
154 amino acids
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:18443288, PubMed:20194754). Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission (PubMed:18443288).
Similarity
Belongs to the FIS1 family.
Mass
17.771 kDa
Sequence
MEDLLNEVVPQEDLERFEKKYHHELELDGEVTTDTKFEYAFCLVRSRYTNDVRKGIMILEELARTHPDGRRDYIYYLAFGNARIKEYTSGLKYCRAFLDIESNDQVRSLEEYIKKEIDKEVAKGMVVAGGAALVLGGILGLGIAMARNKQKREK

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
154 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
17.392 kDa
Sequence
MKKEDYLPNLVDIESPLSDEELYVLSQQYNNEGDFVSVQTRFNYAWGLIKSRKVEDQQLGVQILAQVYKDTPSRRRECLYYLAIGSYKLGEYTDARKYCDLLLQIEPDDPQSAKLRQIIEDKLAKEGMIGIAIVGGVIAVGAAVLGAVLSQKKR

Gene
fis1
Protein
Mitochondrial fission 1 protein
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
153 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
17.064 kDa
Sequence
MTSSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGVQTKFNYAWGLIKSNFRADQQEGVRLLSEIFRAHPERRRECLFYLALGNYKLGNYGEARRYNDLLIDKEPGNLQAASLRTLIDDRVSREGMVGIAIVGGLALAAGVVGGLLFRGQRR

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
153 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
17.134 kDa
Sequence
MVTELPYALDAETPLNPSELNVLKAQYDREGEMVGVQTKFNYAWGLVKSNQRNDQQLGVRLLSDIFRVSPERRRECLYYLALGNYKLGNYGEARRYNDLLLDKEPANLQASNLRSLIDDKVAREGLMGVAILSGVGVAAGVVGAFLLRNARKR

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Homo sapiens
Length
152 amino acids
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Similarity
Belongs to the FIS1 family.
Mass
16.938 kDa
Sequence
MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Gene
Fis1
Protein
Mitochondrial fission 1 protein
Organism
Mus musculus
Length
152 amino acids
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Similarity
Belongs to the FIS1 family.
Mass
17.009 kDa
Sequence
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNEDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Gene
Fis1
Protein
Mitochondrial fission 1 protein
Organism
Rattus norvegicus
Length
152 amino acids
Function
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
16.995 kDa
Sequence
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Gene
FIS1
Protein
Mitochondrial fission 1 protein
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
152 amino acids
Function
Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
Similarity
Belongs to the FIS1 family.
Mass
16.9 kDa
Sequence
MSLPYAADAETSLSPSELQVLKSQYETELASGHVTTQTKFNYAWGLVKSKQRAEMSIGVGLLTEIYRSDPPRRRECLYYLSLGHYKMGNYDEARRFNALLIEREPNNLQAQSLNQLIEKGVAREGYIGMALIGGAAAVASIAIAGLMRRGRR