FGFR2

Fibroblast growth factor receptor 2

887 amino acids

Receptor for basic fibroblast growth factor.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

101.683 kDa

MLNKFIVIVTMLAMWNYAQDCNFELSKNETVQFTSFLPLILNCASISKFDTDLCETINDERPYNWYFQNKKIGNETKGKIKLVSSSQQMIIFNGSASDEGNYMCETINNNKEFISKTFDARMIEPSMTQMELLLNSFPNDHQEEINGRIYWLPEMILNHIRDVVIINQGAESDLHSFYYVSGSDSQISTFDVQWYFHYQPKSEDKTIIDHNIKTFYSSCNDLDLLPRKVNGSCYSSRLYLYNVEIKDQGFYSVEATLRMKNGSSHGLNFTYELKINIANILDPDKTNSILSTPQISFNLNSRVCINDRFDWICKVTPVVSYYVTIYKNNSNPNNITVLAESEVLQMNIDGNSGQGFYLKSSTVNYSVNSVQREHAGVYACRIINFKDYSSDHQNRHEPEVLMRLTVKDCVGNSYFTIIWYSISVGIIILVVISFLIIRLYNKYSNGYIVKTVIVQHPNKLYVPHDTCFPLLMPDITIKTIHKHINSSEDSLLQQKHFTNNSNIPFSQKISKYFRKSFIFSYRHVDVSSSNLDSPLGVISNTETNKLTSNSLTVETQRPQLILQNDANTKYILPSNIGWIFSRDSLIIGSKIGEGAFGIVYSALVKSFSENSASVEVAIKTLHTSFGDQDVINLIQELEMMKIIGRHRHIISLYGACIDNGHPYMVIELAKHGNLRDFLRAQRSQSKVGEIQNSGGLVTRLTVTDFLRFSIEIAEGMEYLSSRKIIHRDLAARNVLVDQYVEMKIADFGLTRIVENYYRKTTDGRLPIKWMAPECLLDRVYTVKSDVWSYGIVLWEIFTMGQTPYPTIQSDGMHQALRNGIRNEKPALASDEMYRLMLTIWNDDPLERHTFSEIIDKLTHIQLSNGGSSPKRDYLEISSNQCYSTTIV

FGFR2

Fibroblast growth factor receptor 2

824 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

92.307 kDa

MFSWSYLMGLVMVATATLSLARPSYNIAEDTTLEPEEPPTKYQISQPDVHSALPGESVELRCLLGDAIMVTWTKDGAQLVSNNRTLLIGPYLQIREAAPRDSGLYACGATRPLQSETRYFIVNITDGNSSGDDEDDNDGSEDFTNDNNHKRAPYWTNTEKLEKKLHAVPAANTVKFRCPAGGNPLPSMRWLKNGKEFKQEHRIGGFKVRSQHWSLIMESVVPSDKGNYTCIMENEYGSINHTYHLDVVERSPHPPILQAGLPANTTTKVGGDREFVCKVYSDAQPHIQWRHIELNGSKIGPDGNPYLKVLKAAGGNTTVKEIEVLYVRNVSFEDAGEYTCLAGNSIGISYHSAWLTVLPDEERQLDSSSSEYTEIAIYCVGGFLIACMIGTIMMCHMKGRGKKSDFSSQPAVHKLSKRLPLRRQVTVSADSSSSMNSNTPLVRITTRLLSNTDTHLLAGVSEYELPEDPKWEYPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKDAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRTRRPPGMEYSFDIFRIPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTETNVIKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTLQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMVKPGNCTNELYTMMTDCWRAVPSQRPTFKQLVEDLDRILTQTTNEEYLDLNNPLEPYSPSYPDTRSSCSFGDDSVFSPDPMSMNLAFPNPNTQMAPLKHEATQPA

FGFR2

Fibroblast growth factor receptor 2

823 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

92.299 kDa

MVSWDSGCLICLVVVTMAGLSLARPSFNLVVEDATLEPEEPPTKYQISQPDVHSALPGEPLELRCQLKDAVMISWTKDGVPLGPDNRTVIIGEYLQIKDASPRDSGLYACTAIRTLDSDTLYFIVNVTDALSSGDDEDDNDGSEDFVNDSNQMRAPYWTHTDKMEKRLHAVPAANTVKFRCPAMGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCIVENQYGSINHTYHLDVVERSPHRPILQAGLPANASAVVGGDVEFVCKVYSDAQPHIQWIKHVERNGSKYGPDGLPYLQVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHTAWLTVLPAPEKEKEFPTSPDYLEIAIYCIGVFLIACMVLTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSADSSSSMNSNTPLVRITTRLSSTADAPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWQAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSGPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPKYQHMNGSVKT

FGFR2

Fibroblast growth factor receptor 2

821 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

92.025 kDa

MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT

Fgfr2

Fibroblast growth factor receptor 2

821 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

91.984 kDa

MVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEAYVVAPGESLELQCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTAARTVDSETWIFMVNVTDAISSGDDEDDTDSSEDVVSENRSNQRAPYWTNTEKMEKRLHACPAANTVKFRCPAGGNPTSTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKNGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTSSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT

fgfr2

Fibroblast growth factor receptor 2

817 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

91.388 kDa

MFARGWLLGALLLMTLATVSVARPSLKIDLVNTSAPEEPPTKNQNCVPVLFSVHPGELLKLKCPLSGADDVVWTKDSSSLRPDNRTLVARDWLQISDATPKDSGLYSCSATGLRDCDVFSFIVNVTDAISSGDDEDDTERSDDVGADGEQMRLPYWTFPEKMEKKLHAVPAANTVKFRCAAAGNPKPKMRWLKNAKPFRQEDRMGGYKVRLQHWTLIMESVVPSDKGNYTCLVENQYGSIDHTYTLDVVERSPHRPILQAGLPANVTVQVGQDAKFVCKVYSDAQPHIQWLQHYTKNGSCCGPDGLPYVRVLKTAGVNTTDKEIEVLYLPNVTFEDAGEYTCLAGNSIGISYHTAWLTVHPAETNPIETDYPPDYVEIAIYCIGVFLIACMVVIVVVCRMRTSAKKPDFSSQPAVHKLTKQIPLRRQVTVSSDSSSSMSSSTPLVRITTRRSSAHDDPIPEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDLCAPVEQYSPSFPDTRSSCPSGDDSVFSHDPLADEPCLPKYQHINGGIKT

fgfr2

Fibroblast growth factor receptor 2

813 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

91.34 kDa

MLLLALLAFLLVSRTIARPSYSMVDDTTPEPEEPPAKYQISKADVFPVLPGEPLDLRCPLADGPLVTWTKDGAKLEVNNRTLIVRTYLQIKESTTRDSGLYACSVLKNSHFFHVNVTEASSSGDDEDDNDGSEDFTNDNNNIRAPYWTNTEKMEKKLHAVSAANTVKLRCPAREPHPSNEWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGIYTCIVENEHGSINHTYHLDVIERSSHRPILQAGLPANTTAVVGGDAEFVCKVYSDAQPHIRWVRYIEKNGSRFGVDGLPYFKVLKAAGVNVTDEEIEVLYVRNVSFEDAGEYTCIAGNSIGISQHSAWLTVHPAPVNPLEDNPVPYYMEIGIYSTGIFIIFCMVVVCVVCRMRQGAKKKKNFTGPPVHKLTKRIPLHRQVTVSADSSSSMNSTTPLVRITTRLLNSTDAMPLANVSEYELPHDPMWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKERPKESVTVAVKMLKDNATEKDLADLVSEMEMMKMIGKHKNIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVSCTYQIARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRILTLTTNEEYLDLSAPLEQYSPSFPDSSCSASSSSGDDSVFSPDPMPHDPCLPKFQHVNGVVKT

FGFR2

Fibroblast growth factor receptor 2

729 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

81.825 kDa

MFSWSYLMGLVMVATATLSLARPSYNIAEDTTLEPEDANSSGDDEDDNDGSEDFTNDNNHMRAPYWTNTEKLEKKLHAVPAANTVKFRCPAGGNPTPSMRWLKNGKEFKQEHRIGGFKVRSQHFSLIMESVVPSDEGNYTCIMENEYGSINHTYHLDVVERSPHRPILQAGLPANTTTKVGGDAEFVCKVYSDAQPHIQWIRHFELNGSKIGPDGHPYLKVLKAAGVNTTDKEIEVLYVRNVSFEDAGEYTCLAGNSTGISYHTAWLTVLPDEERELDSSSEYTEIAIYCVGGFLITCMIGTIMVCHMKGRGKKSDFSSPPAVHKLSKSLPLRRQVTVSADSSSSMNSNTPLVRITTRLSSNNDTHLLAGVSEYELPEDPKWEYPREKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKDAATVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRTRRPPGMEYSFDINRIPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTETNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPGNCTNELYTMMTDCWRAVPSQRPTFKQLVEDLDRILTQTTNEEYLDLNNPLEQYSPSYPDTRSSCSSGDDSVFSPDAMPYDPCLPKSQHTNGTIKT