Protein
Ferrochelatase-1, chloroplastic/mitochondrial
Organism
Arabidopsis thaliana
Function
Catalyzes the last step of heme biosynthesis by inserting ferrous iron into protoporphyrin IX to produce protoheme (PubMed:17416636, PubMed:24329537). Produces heme for photosynthetic cytochromes, but does not seem to be involved in stress responses (PubMed:24329537). May be involved in wound-induced supply of heme to defensive hemoproteins outside plastids (PubMed:17416636). Regulates the expression of photosynthesis-associated nuclear genes in undevelopped chloroplasts through production of heme (PubMed:21565502).
Similarity
Belongs to the ferrochelatase family.
Sequence
MQATALSSGFNPLTKRKDHRFPRSCSQRNSLSLIQCDIKERSFGESMTITNRGLSFKTNVFEQARSVTGDCSYDETSAKARSHVVAEDKIGVLLLNLGGPETLNDVQPFLYNLFADPDIIRLPRPFQFLQGTIAKFISVVRAPKSKEGYAAIGGGSPLRKITDEQADAIKMSLQAKNIAANVYVGMRYWYPFTEEAVQQIKKDKITRLVVLPLYPQYSISTTGSSIRVLQDLFRKDPYLAGVPVAIIKSWYQRRGYVNSMADLIEKELQTFSDPKEVMIFFSAHGVPVSYVENAGDPYQKQMEECIDLIMEELKARGVLNDHKLAYQSRVGPVQWLKPYTDEVLVDLGKSGVKSLLAVPVSFVSEHIETLEEIDMEYRELALESGVENWGRVPALGLTPSFITDLADAVIESLPSAEAMSNPNAVVDSEDSESSDAFSYIVKMFFGSILAFVLLLSPKMFHAFRNL