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FBXL21

Gene
FBXL21
Protein
F-box/LRR-repeat protein 21
Organism
Bos taurus
Length
434 amino acids
Function
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).
Mass
48.995 kDa
Sequence
MKRNRLSFMNKVLQSSPAVKQPKLGCHSSLSQTHMRAALLDWGNLPHHVVLRIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSAASYFNSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACGILSQLVNCSIQTLGLISTAKPSFLNMSKSHFVSALTVLFVNSISLSSIKIEDTPVDDPSLSILVANNSGTLRRLKMSSCPHVSSNGILCVADHCQGLRELALNYYMLSDKLLLALSNETHVNLEHLRIDVMSENAGQIEFHSIKRQSWDALIKHSPGVNVVMYFFLYEEEMETFFKEETPVTHLYFGRSVSKEILGRLGLNCPRLTELVVCANGIQVIDTELICIAEHCKNLTALGLSECEVSCSAFIEFVRLCGRKLTHLSIMEEVLIPDDVYSLGEIHTEVSKYLGRIWFPDVMPLW

Gene
Fbxl21
Protein
F-box/LRR-repeat protein 21
Organism
Mus musculus
Length
434 amino acids
Function
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Mass
49.154 kDa
Sequence
MKRNNFSAVNKVVQSSPVVKQPKRGLCSSLRQTHALSVLLDWGTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVPKSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVADHCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKRSWDALIKHSPRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIGLNCPRLIELVVCANGLLPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIMEEVLVPDDRYTPDEVHTEVSKHLGRVWFPDVMPIW

Gene
Fbxl21
Protein
F-box/LRR-repeat protein 21
Organism
Ovis aries
Length
434 amino acids
Function
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Mass
48.967 kDa
Sequence
MKRNRLSFMNKVLLSSPAVKQPRLGCCSPLSQAHMRAARLDWGSLPHRVVLCVFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFNSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACGILSQLVNCSTQTLGLISTAKPSFMTMSKSHFVSALTVLFVNSKSLSSIKIEDTPVDDPSLSILVANNSDTLRRLKMSSCPHVSSDGILCVADHCQGLRELALNYYMLSDELLLALSNETHVNLEHLRIDVVSENPGQIEFHSIKRQSWDALIKHSPGVNVVMYFFLYEEEMETFFKEETPVTHLYFGRSVSKGILGRLSLNCPRLVELVVCANGIQVIDNELICIAEHCKNLTALGLSECEVSCTAFIEFVRLCGRKLTHLSIMEDVLIPDDVCSLDEIHTEVSKYLGRIWFPDVMPVW