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Elen_1325

Gene
Elen_1325
Protein
3-beta-hydroxycholanate 3-dehydrogenase (NAD(+)) 2
Organism
Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255)
Length
260 amino acids
Function
Involved in the modification of secondary bile acids to form iso-bile acids via epimerization of the 3-OH group through 3-oxo-intermediate. In vitro, catalyzes the reversible oxidation of 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA) to yield isodeoxycholate (isoDCA) and isolithocholate (isoLCA), respectively. It prefers NADH to NADPH.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
27.311 kDa
Sequence
MSEARHNPVLAGQTAVITGGASGIGKSIVQRFLEAGASCLAADLNEEALAALKQELAEYGDKLDVVKVDVSNRDDVEGMVDRAVQTFGQMDIIVNNAGIMDNLLPIAEMDDDVWERLMKVNLNSVMYGTRKAVRYFMERGEGGVIINTASLSGLCAGRGGCAYTASKFAVVGLTKNVAFMYADTGIRCNAICPGNTQTNIGVGMRQPSERGMAKATTGYAGATRSGTPEEISAAAAFLASDQAGFINGETLTIDGGWSAY