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Elen_0690

Gene
Elen_0690
Protein
3-alpha-hydroxycholanate dehydrogenase (NAD(+))
Organism
Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255)
Length
259 amino acids
Function
Involved in the modification of secondary bile acids to form iso-bile acids via epimerization of the 3-OH group through 3-oxo-intermediate. In vitro, catalyzes the reversible oxidation of deoxycholate (DCA) and lithocholate (LCA) to yield 12-alpha-hydroxy-3-oxo-5-beta-cholan-24-oate (3-oxo-DCA) and 3-oxo-5-beta-cholan-24-oate (3-oxo-LCA), respectively. It prefers NADH to NADPH. Also able to catalyze the oxidation of cholic acid (CA) and chenodeoxycholic acid (CDCA) into 3-dehydrocholate (3-oxo-CA) and 7-alpha-hydroxy-3-oxo-5-beta-cholanate (3-oxo-CDCA), respectively.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
27.383 kDa
Sequence
MGIYVITGATSGIGAKTAEILRERGHEVVNIDLNGGDINANLATKEGRAGAIAELHERFPEGIDAMICNAGVSGGKVPISLIISLNYFGATEMARGVFDLLEKKGGSCVVTSSNSIAQGAARMDVAGMLNNHADEDRILELVKDVDPAIGHVYYASTKYALARWVRRMSPDWGSRGVRLNAIAPGNVRTAMTANMLPEQRAAMEAIPVPTHFGEEPLMDPVEIANAMAFIASPEASGINGVVLFVDGGTDALLNSEKVY