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Elba3

Gene
Elba3
Protein
Early boundary activity protein 3
Organism
Drosophila melanogaster
Length
379 amino acids
Function
The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2 (PubMed:23240086).
Mass
43.008 kDa
Sequence
MSNISNDSGLDDSANSGAVVSANGPLAATRLSWFLAEVDDGLMKDGKPNGRRRLCVLHSMELLESDVSDKYMTRFVEFRVNGMVLEAKLILAADERRLVDAALLSMSKEEREDAGGQQLLVQYTENEKAGERLIQKLVSPNNVMLLSTKPELKGNPLVRLAPGCIAHILYAYESRDYMEKILLHLKARSFDLAFDDNLEAEPEAMNDDTWMLVQYSPEPEMVVYQVVQYRQTVWRKENLFKDVIAYMQLPGSDIVLQAVVISYGQDKEVQDAKYEELQRFSFDIDFPLPEELEKHPDHMTSTALFSRTSLYQKAEQRDTTGEHRELRKSLEQMSEKAQGEAQMIIDAFDMVDNINKNLQSRLSGEVRSVVEVTSGDELH