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ERO1

Gene
ERO1
Protein
Endoplasmic oxidoreductin-1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
563 amino acids
Function
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.
Similarity
Belongs to the EROs family.
Mass
65.033 kDa
Sequence
MRLRTAIATLCLTAFTSATSNNSYIATDQTQNAFNDTHFCKVDRNDHVSPSCNVTFNELNAINENIRDDLSALLKSDFFKYFRLDLYKQCSFWDANDGLCLNRACSVDVVEDWDTLPEYWQPEILGSFNNDTMKEADDSDDECKFLDQLCQTSKKPVDIEDTINYCDVNDFNGKNAVLIDLTANPERFTGYGGKQAGQIWSTIYQDNCFTIGETGESLAKDAFYRLVSGFHASIGTHLSKEYLNTKTGKWEPNLDLFMARIGNFPDRVTNMYFNYAVVAKALWKIQPYLPEFSFCDLVNKEIKNKMDNVISQLDTKIFNEDLVFANDLSLTLKDEFRSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADEFTKQHIVGKLTKYELIALLQTFGRLSESIESVNMFEKMYGKRLNGSENRLSSFFQNNFFNILKEAGKSIRYTIENINSTKEGKKKTNNSQSHVFDDLKMPKAEIVPRPSNGTVNKWKKAWNTEVNNVLEAFRFIYRSYLDLPRNIWELSLMKVYKFWNKFIGVADYVSEETREPISYKLDIQ

Gene
ERO1
Protein
Endoplasmic reticulum oxidoreductin-1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
561 amino acids
Function
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between PDI1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
Similarity
Belongs to the EROs family.
Mass
64.954 kDa
Sequence
MVKVLQLCFLSAISLVQALNSTVDQKDEAKVDINTVFDNDSTNFCRMDKTEAIGATCDVTFHEINEVNNNIRPQLLSLVQSDFFKYFKLDLYKECPFWSDNNGYCVNRACAVDVVEDWDSLPEYWQPEILGNIENATTDITDDECSFLDELCDKPRFEAEKDIEYCDTNDFNSQHSVLVDLTANPERFTGYGGEQSSQIWSSIYKENCFSLGDENQCLAKDAFYRLISGLHASIGTHLSNEHLNTETGKWEPNLELFMTRVGNFPDRVSNIYFNFAVVAKALWKIRPYMNELGFCNAYNEDVKGMIDGVVSQLNSKVFNEDLLFHDEVSGQLKDDFRIRFKNVTKIMDCVQCDRCRLWGKVQTTGYATSLKILFEMDNDDDVARQHVVDKLTKYELIALFNTFDRLSKSVEAVNRFEEMYNYQLKSPGEKLASFFQLDNFFKVLNDKFNSANHSSQEKESVSNVEKKVNEFNDLKMPEKKKETHTEVREQASGVFKEAWDVEWKNFKQALRFIVTSYTDLPSTVSKYTVLKLNKLWNKFIGVPNYLEEGEELEYPSYNYEE

Gene
ERO1
Protein
Endoplasmic reticulum oxidoreductin-1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
546 amino acids
Function
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between PDI1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
Similarity
Belongs to the EROs family.
Mass
62.527 kDa
Sequence
MQLNKLMLGFMLCASALADDGQQAAEPHTSANFCKIDKDQQVGSTCDITFHELNEINEQIRPQLARLVKTDFFRYFKLDLYKECPFWSDNNGYCVNRACAVDVVDDWESVPDIWQPEVLGGLDEDSVKSEGGESDECSFLNELCGRRREFARPEPLSIDYCDVTDFTNKDSVLVDLVANPERFTGYGGEQSAQIWSAIYKENCFTLGEQGFCLAKDVFYRLISGLHASIATHLSNDYLDTKTGKWGPNLELFMARVGNHPDRVANIYFNFAVVAKALWKIQPYLERVEFCNVYDTNVKDMISNVVSRLDSRVFNEDLLFQDDISMRMKDDFRRRFKNVTKIMDCVHCDRCRMWGKVQTTGYATSLKILFEMDAGDEKARQRVVDKLTKYELIGLFNTFDRISKSVNAINNFERMYHSQMETNTSSIAAFFQNNFFRLGFTETEDQETSNATADMPLPEDSASDNEPYFADLKIPARRSKKQTKEESTSALQQELQGVYHALQFIWNSYVNLPRNLLILVLDVANTWFNNFIGVPTQINILGDDASD