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ERN2

Gene
ERN2
Protein
Serine/threonine-protein kinase/endoribonuclease IRE2
Organism
Homo sapiens
Length
926 amino acids
Function
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
102.48 kDa
Sequence
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR

Gene
ERN2
Protein
Serine/threonine-protein kinase/endoribonuclease IRE2
Organism
Homo sapiens
Length
926 amino acids
Function
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
102.48 kDa
Sequence
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR

Gene
Ern2
Protein
Serine/threonine-protein kinase/endoribonuclease IRE2
Organism
Mus musculus
Length
911 amino acids
Function
Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
101.262 kDa
Sequence
MARPVQRFQLWSPLGFLLQLVTLLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPGKYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDLHAPPVFFELLNLRREDPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPPALEARRPDATKS

Gene
Ern2
Protein
Serine/threonine-protein kinase/endoribonuclease IRE2
Organism
Mus musculus
Length
911 amino acids
Function
Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
101.262 kDa
Sequence
MARPVQRFQLWSPLGFLLQLVTLLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPGKYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDLHAPPVFFELLNLRREDPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPPALEARRPDATKS

Gene
ERN2
Protein
Ethylene-responsive transcription factor ERN2
Organism
Medicago truncatula
Length
313 amino acids
Function
Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs). Binds to the GCC box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Involved in early stages of root nodule development. Functions redundantly with ERN1. Is essential with ERN1 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242).
Similarity
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
Mass
34.658 kDa
Sequence
MEIQFDEPKKSLRPKKVNKFKGRNKKSETRDKFVGVRQRPSGRYVAEIKDTTQNIRMWLGTFETAEEAARAYDEAATLLRGSKTRTNFVTHVSYDSPLASRIRHLLNNRKKGTKQQDMNGISSTTSHADTTNDTTSDGSTSSTTNCIGTASGAINSTSASGVTSTSTNISTSASGVASTSTDISTNSSNTNVNDKSESLLSSSTTMQKPNLFEDAYRPDMSNLTNEYESSSYKSNVSWDFGPIFDNFPFDQWLDMTNNDGLLCDMVDKGVSEFERMKVERQISASLYAINGVQEYMKNVQDCNEAQWNLSPLC

Gene
ERN2
Protein
Ethylene-responsive transcription factor ERN2
Organism
Medicago truncatula
Length
313 amino acids
Function
Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs). Binds to the GCC box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Involved in early stages of root nodule development. Functions redundantly with ERN1. Is essential with ERN1 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242).
Similarity
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
Mass
34.658 kDa
Sequence
MEIQFDEPKKSLRPKKVNKFKGRNKKSETRDKFVGVRQRPSGRYVAEIKDTTQNIRMWLGTFETAEEAARAYDEAATLLRGSKTRTNFVTHVSYDSPLASRIRHLLNNRKKGTKQQDMNGISSTTSHADTTNDTTSDGSTSSTTNCIGTASGAINSTSASGVTSTSTNISTSASGVASTSTDISTNSSNTNVNDKSESLLSSSTTMQKPNLFEDAYRPDMSNLTNEYESSSYKSNVSWDFGPIFDNFPFDQWLDMTNNDGLLCDMVDKGVSEFERMKVERQISASLYAINGVQEYMKNVQDCNEAQWNLSPLC