Protein
Serine/threonine-protein kinase/endoribonuclease IRE2
Function
Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Sequence
MARPVQRFQLWSPLGFLLQLVTLLGKLGPQVQSVRPESLLFVSTLDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPGKYMSHLTSCGMGLLLTVDPGSGIVLWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQFSSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDLHAPPVFFELLNLRREDPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQQQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSALEAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPPALEARRPDATKS