elp2

Probable elongator complex protein 2

901 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.

Belongs to the WD repeat ELP2 family.

100.804 kDa

MNVSSDVDFISVGCNCLGDCLVWGQNKLAAYGAQNFIALFDPIQSKVLATLPGHKDRVNHICWVPNINEEYKNRYSSYENELLSCSSDNTIISWKQIKGGLNYQYKVVEVLKGHSDSVTNISVLDFPDGSLLMCSTSADNTVKLWRRESLTKENIDTDTLPKWECIQTIDFTPKCMECSSLAFIPGTTIPLLAVGGLEPKIHIYIQNLDSTTATLQFKKLMSLQGHQDWIRSLSFKTINEGEGEGEEEELILASSSQDFKIRLWKISKFTAEKQKQQQLDESGNGGANLLGSLSTQLSGVTSLSTKGYLFNCNSVKYIILLDAVLSGHDDWVYSIHWSPARRDQETGKKIQEQMLISASMDKTAIVWRPDRTTGIWIDESRVGDMGGNILGQYGAVFSPCSQYILSHGYNGAFHFWKQNTNQKSSFWEPQIVVSGHFGPVQDLMWSPDYSYFISCSTDRTLRLFSEWKRNNNNNNLENNKEQQIISWNEIARPQIHGYDLECFTFINKKTHVIVSGAEEKIMRAFVGSQNFVDTLLNISKVQPVNDGTQRPLAANQPSLGLSNKPYFTGGSDYNENIDNNNNNNNNNGNGEENTEDSIKMKMGGGDEGGGGEGMDTGYFEDEIPFNPEVLSEPPFEEHLLQSSLWPEIHKFYGHGNEIVAVACSADGMYLASTCRASSADQATVRIWNVSNWKECANLKGHTLTVVNLSFSHNSKYLLGVSRDRMWTLWERSASNSEEPFVKVISAPKSHGRIIWSGSWSHDDKFFATGARDKLVKVWNLDNIKDIKNACASTLPAFGSGVTCVEFAPKSSKFTGEHGDHLLAVGEDDGKITIWKSTTSTSNPKSLDWTCVHTISPLISHTLDVRRIRWRDTPTINGNSLTYQIVTCSVDHSVRIFNIKFD

ELP2

Elongator complex protein 2

838 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Promotes organs development by modulating cell division rate. Prevents abscisic acid (ABA) signaling leading to stomatal closure and seedling growth inhibition. Involved in oxidative stress signaling. Prevents anthocyanins accumulation. Accelerator of defense gene induction required for rapid defense gene induction, and for the establishment of both basal and effector-triggered immunity (ETI), in a NPR1-independent manner, but is not required for systemic acquired resistance (SAR) establishment.

Belongs to the WD repeat ELP2 family.

92.681 kDa

MSENTKVEAKRVFIGAGCNRVVNNVSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPTSKFAFKAKKLDRQYLLSGDSDGIIILWELSTLNNDWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVSFPSQPSEECKVVCLDSICVDTKAIVTLSLAELPQNPGRFALALGGLDNKIKLYSGERTGKFTSVCELKGHTDWIRSLDFSLPLHTTEEIPNSIMLVSSSQDKVIRIWKLVLVGDVGSWRREITLASYIEGPVFVSGTFTYQISVESVLIGHEDWVYSVEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSKESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAWKNDEGNEAEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTLNHTCAGGEGSFPEDLQADVQVLGANMSALGLSQKPIYLHSSSEPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDNGEVSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKQILVLPPFGSSVTAVAWTGLDRNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNRLAWRPTEKCESNQSLRWLTSCGDDNCVRVFNFKF

Elp2

Elongator complex protein 2

831 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).

Belongs to the WD repeat ELP2 family.

93.093 kDa

MVSSVLEVSHVFCCPNRVRGALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIRTEDGSPSNELVSGGSDNRVIHWELENNQVLKSVRLQGHEGPVCAVHAIYQSGPSEGEQHALIASAASDSTVRIWSKKGSEVKYLQTLSFRDGFVLSVCLAILPGTNVPVLACGDDDCRIHLYIQQDDQFQKALSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPASFETKDGSLRLKENTFTIKDGGVRTTVAVTLETVLAGHENWVNAVHWQPSFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTVNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFAPWKKKDQKDRSQVTWHEIARPQIHGYNIKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLCDDQDLPEGATVPALGLSNKALFQGDIASQPFEEDELISPAFGSPQVTFQPAVLNEPPTEDHLLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACKASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATSSEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVWGECKSSHNPMEHPIRPCSSILDVGSSVTAVSVCPVLNPAQRYIVAIGLESGKICIYSWNKTNQEINDWTSCVETNPSQSHSLGIRRLCWKSCSDDDDDDDDDDTEQSEEGPEWLHFASCGEDHTVKIYRVNRRAL

ELP2

Elongator complex protein 2

826 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

Belongs to the WD repeat ELP2 family.

92.5 kDa

MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL

elp2

Elongator complex protein 2

824 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.

Belongs to the WD repeat ELP2 family.

92.123 kDa

MSAPIVQLAHAAFSVNRCPSCVSWSRTGILACATCHSIALYDPQKNVVISTLNGHTGRVNCVHWVQKNDCSAETELVSGGSDKKVIIWAIEKNKCEQPVAAEGHTEVVNAVHAVYTQRSENELLIVSAASDCTVRLWLRRNVKTECLQTLSFGKGFVLDVCISFLPGSLVPVLACGADDSRIHLYVLQNEQFEKTQVLHGHEDWIRGVEWAVTGQNLFLASCAQDCLIRIWKIFRKTAKENSKTEDENSIKLKENIFKVKEKDTETSYAVTLETVLTGHENSIYAVHWQPSFSRDGSIVQPMSLLSASMDKTMILWEPDEESGVWLEQVRVGEVGGNTLGFLGCQFSPDKSMILAHAFHGALHLWSRAPNKQNEWIPMVIISGHFDSVQDMRWDPDGQFVITVSADQTTRLFGPWKKKGQSHVTWHEIARPQIHGYDMQCLAMIGRFQFVSGADEKVLRVFAAPRNFIENFSNISCISVEKLLLNEDTNLPEGATVPALGLSNKAVFHGEILIQSTQEEGKYNSVSEQYSQPNFQPLNLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFAVACNSAKTVIASACKASKREHAAIILWSTTSWKQLQSLSYHNLTVTQMAFSPDDEFLLVVSRDRNWSLWKKQEGIPEQTEPTFTLYASTDKNSCVHSRIIWACDWTPDSKYFVTGSRDKKVIVWGDCSLPSMNEEKSSALIRPCSSLLDTGDSITAVSVSQVLALDGSYIIAVGLDCGIIQLYKWKHSGTVNDWLKCLAMDQSLLSHTLTVKQLCWRSCLGRAGHDDRDNGDWIQLASCGADHCVKIFDVYRKAL

elp2

Elongator complex protein 2

821 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.

Belongs to the WD repeat ELP2 family.

90.083 kDa

MAAPVMDTCHVSCCANRAPNVVSWGRGGLIAFGTCNSVAIYNPEEIRVVDLLNKHTGRVNAVQWVHEPDCSPENQLISGGSDNNVIVWEKLDGKFRACAVCSGHSGPVCAVDAVSLSSSHLLVASASSDSTVKLWTYSSDAAECLQTVAFGSGFMMDVSLALLPGSRVPVLACGGDDSRVHLYVQLSGQFQRVLTLTGHEDWVRGVEWANKDGELWLASCSQDCLIRVWRLFAKTAAEPDLQTDGIIKMKENIFQVSGEEFAVTLETVLAGHENWVYGIHWQPPSVKGDSVEQSLKLLSASMDKTMILWGPEEDSGMWVEMVRVGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSNQEWRPSVVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLFTPWTRKGSSQITWHEISRPQIHGYDMQCLTMVGRFQFVSGADEKVLRVFKAPRNFVENFAHISGTSLEKLLGCNDIADLPEGASTPALGLSNKAVFQGDLASPSPQQDGGDFNSLSDQYKESYFQPLKLAEPPTEDDLLQNTLWPEVQKLYGHGFEMFCLASDCARTVVASACKASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWRRGNPDLDTEAMFSLYANTSKDTSVHTRIIWSCDWSADNKYFVTSSRDKKVIIWGHAVSGVAVGEGEDARVTSCSSVLDVGDSATAVSICPFLCSDHSYLLAVGLENGQILLYKWKPLEDLSSESDWSRCKDTDACQGHTMVVKRLRWRPRLGRGGHGGQDSKEEQAWVQLASAGADHVVKIFDINLSAL

Elp2

Elongator complex protein 2

821 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).

Belongs to the WD repeat ELP2 family.

91.746 kDa

MVSSVLEVSYVFCCPNRARGALSWNSGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLHWIRTEDGSPSTELVSGASDNRVIHWELENNQVLKSVRLQGHEGPVYAVHGIYQSGPSDGEQHALIASAASDSTVRLWSKKGSEVKCLQILKFGDGFVLTVCLSTLPDTDAPVLACGDDGGRIHLFVQQDDWFQKMLSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPTSLETEDGSIRLKENTFTIKDGGVSTTVAVILETVLAGHENWVNAIHWQPSFYKDGVLHQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYGCQFGENGSMIIAHAFHGAMHLWKQSTVNPRQWAPEIVISGHFDGVQDLIWDPEGEFIITTSTDQTTRLFAPWKKKNQSQVTWHEIARPQIHGYNLKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENFSVISRQSLSHMLYDEDNDLPEGATVPALGLSNKAVFEGDMTYLTSEEEELLSPAFGYPQVIFQPAVLSEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNNSKTLLASACKAAQKEHAAIILWSTTSWKQVQSLAYHTLTVTQMAFSPDDKFLLAVSRDRTWSLWKRQDVTSAEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECNSSYNPMEHPINPCSSILDVGSCVTAVSVCPVLNPAQRYIVAVGLESGKICIYSWSKTNQETKDWTSCVETTPSQSHTLGIRRLCWKSCSGSTEQSEEGTEWLDFASCGEDHTVKIYRVNRCAL

Elp2

Probable elongator complex protein 2

794 amino acids

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Involved in the regulation of the STAT pathway.

Belongs to the WD repeat ELP2 family.

88.974 kDa

MQVENLHTSVACNRCTECADWGPNGWIAYGACNAIAIMDPKFQGNSAKVLFTLVEHTKRVNTVRWLDCDKLLSGGDDAIAILWELDETGTTKSFTLKGHTSGVNTVDGIRQQDGSWLLATAAADTTIKLWTFQDNNYVCFQTISLSDGFCFCLRLQLLPKSNQVLLAFSGDDETVSLWSEQVETAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRIAPRSKEQMQENRVDLHQLSHNDDEIKVEEKILQLGKEAWYAVSLESVLYGHEGWIYGVHWHKTPDQELRLLSASIDKTVIIWAPTEEGIWLEEVRVGEVGGNSVGFYGGKFSGDGHSIMAHSYQGGFHIWSQDPDRPQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAPWLQDGANPTWHELARPQIHGYDMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIENDDAGDVLLDSLPKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEYPDNYFVPIALETPPQEETLMQNTLWPELQKLYGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQKLSGHQLTVTQLSFSPDSRYLLSVSRDRRWCLYERQDSSVSYQLVASTDKSNGVHTRIIWSCDWSHDGQFFVTSSRDGKVVVWKKEEDCKESSLNGWQANGVLELKNESITAVAFSNSYLSGTDDTYILALGTETGLIKIYQFVRGAWKLLSDLNKSQAHHLTVRRLQFRPGKQLQLASCGEDHLVRIYDIKLT

ELP2

Elongator complex protein 2

788 amino acids

Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP2 is dispensable for the complex integrity and, in vitro, is not required for complex HAT activity. It is not required for the association of the complex with nascent RNA transcript. Independently, ELP2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.

Belongs to the WD repeat ELP2 family.

89.411 kDa

MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLAYE

elp2

Elongator complex protein 2

760 amino acids

Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. Independently, elp2 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA (By similarity).

Belongs to the WD repeat ELP2 family.

84.949 kDa

MFQYEALHVGCNRIPTAATWSSNLGLIYGAERLIAVADPFKEINYLMAGHSGRINCVCELATNSEYRSPFILSGASDKTLRLWQLEEEYFTCIKTIELEATVNCLCVNENLVVCGCSNSSCIVYSWNAEQRNLTEISRFTCSEIIPLEFAIVKLDHGIILTVCGSSKKIMVYGSDSAISSFKLKAVLRGHLDWVRTLSFKKTSGSTATLASGSQDRYIRLWNISLWGSEDEKVSEEFFESVLSNKPVRFTLGKIDLKIVFDALLMGHEDWVMSVDWHPTKEMILSSSADSSMIVWEPDTNTGIWVVTGRMGEMASSHGSTTATGSAGGFWGGLWNPNGNCVVCWGRTGGWRLWKQDAGQWLQLPSISGHTKSVKGVAWDPEGKFYLSAGTDQTTRLFARFKKDNAWHEMARPQIHGYDLTSISCMPSRIGFLSCADEKVSRVFKFPKTIVRLLYRLCDTNIGEESLPDAANVPLLGLSNKATTASETGTVNAEEVQTPVADVIGSLNHPPFEEHLQRLLLFPEVEKLFGHGYEVYACAISNNGNIAATSCKSQTPEHAVIRLYETQSWNQQQVLKGHSLTVTTIKFSPDDRYILSAGRDRLVCLHEQAENLLDYNNFASIKAHSRIIWDASWAPKEMGYFFATASRDKFVKFWKINDNKKICDVAALQFSDAVTAVDFAPFFHNDELLLAVGTEAGKIFIWRCPRENLTKWYPTRLPDHMAPMESINQILWKPTFETMGLYSLLIAGEDTSVRLLNVTLG