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EIF3G

Gene
EIF3G
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Bos taurus
Length
320 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
35.655 kDa
Sequence
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSLEPELLPGAPLPPPKEVINGNIKTVTEYRIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Gene
EIF3G
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Homo sapiens
Length
320 amino acids
Function
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Similarity
Belongs to the eIF-3 subunit G family.
Mass
35.611 kDa
Sequence
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Gene
Eif3g
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Mus musculus
Length
320 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
35.638 kDa
Sequence
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLPTGDTSPEPELLPGDPLPPPKEVINGNIKTVTEYKIEEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQAAQSKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Gene
Eif3g
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Rattus norvegicus
Length
320 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
35.651 kDa
Sequence
MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLPTGDTSPEPELLPGDPLPPPKEVINGNIKTVTEYKVEEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQAAQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Gene
eif3g
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Xenopus tropicalis
Length
310 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
34.573 kDa
Sequence
MPTEDYDSKPSWADQVEEEGIDPEPISPPVTKVQQDPASFVLDTPQEVINGKIKTITEYKLNDEGKKIKIVRTFKIETLKASKVVAHRKNWKKFGNSEYDPPGPNVATTTVSDDVLMTFITSKEDLNNQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGDKEKAPGAEPEPAQAPVSKTGKYVPPSLRDGGSRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN

Gene
eif3g
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
297 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
32.364 kDa
Sequence
MAAVQQKHDWADDDELEETSTELPPPQKITNKDGSTTIIEYRLNDNGQKVKTTRRIRYITHREVVNPRVAERKSWTKFGLSVKDGAGPAPDTTSVGENIIFKPSFNWRQEAKDESKDPNAQAMKDKLKDKKVKCRICNGEHFTARCPYKDTMAPIGEAGAAADVAASAADEAAAASQGAAGAGKKGSYVPPALRGAGGAAAAGERMGGKYGERDDLATLRVTNVSEMAEEQELRDMFERFGRVTRVFLAKDRDTGLAKGFAFISFADRSDAVKACAKMDGFGFRHLILRVEFAKKAA

Gene
eif3g
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Danio rerio
Length
293 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
32.844 kDa
Sequence
MPSIEFDDSKPSWADQVEEEGDEGSLPSPKETVKGNIKTVTEYKIDDDGQKFKIIRTFKIETRKASKAVARRKNWKKFGNSEYDAPGPNVATTTVSDDVFMTFISSKEDLNAQDQDEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKAAEPEPAQPVQNKTGKYVPPSLRDGGTRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKNTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSNN

Gene
eif3G
Protein
Eukaryotic translation initiation factor 3 subunit G
Organism
Dictyostelium discoideum
Length
233 amino acids
Function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
Similarity
Belongs to the eIF-3 subunit G family.
Mass
26.531 kDa
Sequence
MTSTNIDNRVPIEKTIEVIVKNDKGEEVKVIKRYQEYQITVKRNRKVDERKKWKKFGECDNKTGLENTAYGDEQFLVLTRGAEVKEEEKDVVKCRICKKNHFTTKCPYKDALELTTQPQKSEKEEKPISNKYIAPNLRGGYTGSAPSGSDVPSIMVSNLSQNATEKDLYELFGQFGPVSRVSIPKSMEGSSKGFAYVTYNHLDSAEKALKQLNGHRYDYLVLSLEFAKKKSLN