Function
MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence. Modulates also stress response (e.g. drought) signaling and cell death, in an ORE9-dependent manner. Functions at a point of cross talk between ethylene, ABA and SA signaling that impinges on senescence and cell death. On the other hand, it confers sensitivity to various pathogens such as the fungus E.cichoracearum, the oomycete H.parasitica and the bacteria P.syringae pv. tomato DC3000. Required for resistance to some hemibiotrophic/necrotrophic fungal pathogens (e.g. C.gloeosporioides, C.higginsianum and A.brassicicola) through the induction of defensin expression, probably by repressing MYC2, an inhibitor of defensin genes (PDFs). Together with KEG, may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses.
Sequence
MKHIFKKLHRGGNQEQQNRTNDAAPPSDQNRIHVSANPPQATPSSVTETLPVAGATSSMASPAPTAASNRADYMSSEEEYQVQLALAISASNSQSSEDPEKHQIRAATLLSLGSHQRMDSRRDSSEVVAQRLSRQYWEYGVLDYEEKVVDSFYDVYSLSTDSAKQGEMPSLEDLESNHGTPGFEAVVVNRPIDSSLHELLEIAECIALGCSTTSVSVLVQRLAELVTEHMGGSAEDSSIVLARWTEKSSEFKAALNTCVFPIGFVKIGISRHRALLFKVLADSVRLPCRLVKGSHYTGNEDDAVNTIRLEDEREYLVDLMTDPGTLIPADFASASNNTVEPCNSNGNKFPTAQFSNDVPKLSEGEGSSHSSMANYSSSLDRRTEAERTDSSYPKVGPLRNIDYSSPSSVTSSTQLENNSSTAIGKGSRGAIIECSRTNMNIVPYNQNSEEDPKNLFADLNPFQNKGADKLYMPTKSGLNNVDDFHQQKNNPLVGRSPAPMMWKNYSCNEAPKRKENSYIENLLPKLHRDPRYGNTQSSYATSSSNGAISSNVHGRDNVTFVSPVAVPSSFTSTENQFRPSIVEDMNRNTNNELDLQPHTAAVVHGQQNDESHIHDHRKYTSDDISTGCDPRLKDHESTSSSLDSTSYRNDPQVLDDADVGECEIPWNDLVIAERIGLGSYGEVYHADWHGTEVAVKKFLDQDFSGAALAEFRSEVRIMRRLRHPNVVFFLGAVTRPPNLSIVTEFLPRGSLYRILHRPKSHIDERRRIKMALDVAMGMNCLHTSTPTIVHRDLKTPNLLVDNNWNVKVGDFGLSRLKHNTFLSSKSTAGTPEWMAPEVLRNEPSNEKCDVYSFGVILWELATLRLPWRGMNPMQVVGAVGFQNRRLEIPKELDPVVGRIILECWQTDPNLRPSFAQLTEVLKPLNRLVLPTPQ