Protein
Probable DNA-3-methyladenine glycosylase
Organism
Encephalitozoon cuniculi (strain GB-M1)
Function
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Similarity
Belongs to the DNA glycosylase MPG family.
Sequence
MDMGIPCSQLARRLLGKMLCRRIEGRTTKGMIVETEAYLGKEDKACHSYGGRRTERNSAMYMKAGTCYVYRIYGRYECFNISSVEAGAGVLVRALEPLCGVSEMRERRGGRVKDRDIANGPSKLCIAMGITRREIDKEWIAGSEKIWLEEGREVADPEIVAGRRIGIRNCGEWEEKKLRFYIRDNEFVSCIRRRELGNRKHGSVQQLP