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ECU04_1180

Gene
ECU04_1180
Protein
Inosine triphosphate pyrophosphatase
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
192 amino acids
Function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.149 kDa
Sequence
MGRIYFATTNLKKLKEIRSLFEADIVHMNIPMVEIQASLERIVDHKLNQVVPCIGEGDAVIVDDTAVAFEGLYGFPGVYIKDFLRIGSRKISEIVGKIGNSNATAFCCLGIAHYRDGRVVKKVFFGELEGSIVESKEDGLEGFDYIFLPSGSSMCLGDMPVDEKNRISHRRIASKKLADYMASVGIIKAHGS