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E(spl)mdelta-HLH

Gene
E(spl)mdelta-HLH
Protein
Enhancer of split mdelta protein
Organism
Drosophila melanogaster
Length
173 amino acids
Function
Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm (PubMed:28899667).
Mass
20.195 kDa
Sequence
MAVQGQRFMTKTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQEEEIIDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW