Dredd

Caspase-8

511 amino acids

Effector of the programmed cell death (PCD) activators rpr, grim and W. May play an apoptotic role in the germline as well as soma. Role in immune response, required to resist Gram-negative bacterial infections by regulating DptA. Fadd interacts with Dredd, Fadd promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

Belongs to the peptidase C14A family.

57.576 kDa

MSGHNILTQLESIDVLDLPYVERDLNFAQLVSLSFLLYGDEHSTATYILQKLLVLARATASDWPHSDILSQYAKSKPQTWRKYLVEALCIIGARQVLRKLGLCWQELRMHYLPHVGSIRVHIHPLLKSLYTICEELTLAQRGRMVLDIKEKNSVGDPLRFYDAEYLEIFLLDWLTRRLIRLGDFNANGSDVQLLIEYFKFNDLHAQATLLVDTVNAYATSSCSPATPNVLLPMDGNGIANESSSPTAAASRPRAKNALQLSRENAGIALIINQQEFYRDANDDYKVYLPPIELPLRNGTDMDKQRLTNVFSMLGYKVEAHDNLDHLSMLHHIRQACKRSLLHESLVVCILSHGFEDAVYGANSVALRISDIENVLCSYENLYEKPKLVVIQACQQEDKENNALPYKINASTKSPCQYLNMLRAMSTVPGFPALRHTQTGSWFIQSLCDAIVEHSNSDHIADILTIVINNVANKRGNKNETMVPWTGGALRQHVYFPRTSATDKVVPDSPGL

Dredd

Caspase-8

494 amino acids

Effector of the programmed cell death (PCD) activators rpr, grim and hid (PubMed:9740659). May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (PubMed:10934188). Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection (PubMed:11269502). Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA (PubMed:22549468).

Belongs to the peptidase C14A family.

56.153 kDa

MAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAMTRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELFRIDVTTVSPDQHIDMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNVKSTFRQHVYFPPRL