Protein
Deoxyhypusine hydroxylase
Organism
Plasmodium vivax (strain Salvador I)
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Sequence
MTGSTHNGGSRLIQYEDSSNKEFIRKYLVETRNEFIEKQMRALYECREIYKDDIDEVINILTYALENNDSVLLRHEVAYVIGQISNEKCNDILIKLLNDTEENLMVRHEAAEGLAAIGSDSNIEVIKKFLNDEKVEVRETCELALSSLLEKNKYAVCSCSNKDSIKEAIKKKRNDEFVSKKFNTIDPVVFTSSGNAKSVDALIEDLNNEAVPLKLRYEALFKLRDMETDVSINALGEVLIKDKKSAIFRHEVAFVLGQALHLNSLKYLISSLQNVGEHEMVRHEVALALGSLGSLNINSQEYKNVQSEIISTLKTFSKDACRVVAESCLVGLDYIAENLNMAIEVN