About Products Protein Database Contact

Dohh

Gene
dohh
Protein
Deoxyhypusine hydroxylase
Organism
Plasmodium vivax (strain Salvador I)
Length
346 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
39.009 kDa
Sequence
MTGSTHNGGSRLIQYEDSSNKEFIRKYLVETRNEFIEKQMRALYECREIYKDDIDEVINILTYALENNDSVLLRHEVAYVIGQISNEKCNDILIKLLNDTEENLMVRHEAAEGLAAIGSDSNIEVIKKFLNDEKVEVRETCELALSSLLEKNKYAVCSCSNKDSIKEAIKKKRNDEFVSKKFNTIDPVVFTSSGNAKSVDALIEDLNNEAVPLKLRYEALFKLRDMETDVSINALGEVLIKDKKSAIFRHEVAFVLGQALHLNSLKYLISSLQNVGEHEMVRHEVALALGSLGSLNINSQEYKNVQSEIISTLKTFSKDACRVVAESCLVGLDYIAENLNMAIEVN

Gene
DOHH
Protein
Deoxyhypusine hydroxylase
Organism
Leishmania donovani
Length
326 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
35.753 kDa
Sequence
MSALNSRTVEEVRKDYAKLLDPQEPLDSRMRELYRLKEDCLKTAAGVTVILETIDTTDSVLLQHELAYNAGQSGREEAVPELERILRTTSYDVVTRHEAAEALGAIGSPLALQVLEAHSDPTTEPEAPIRETCELALARIAMKETKGDAAVAPPSGCEFVSVDPSPAFSALYSSTDEPVPHTVEELEAVLLDTSGRTRLFRRYMAMFTLRNLATEAAVAALCRGLREDNVSALFRHEVAFVLGQLERPSSQPALIAALKDEEEAPMVRHEAAEALGAIADPATLPVLESYATHHEPIVRDSCVVALEMHKYWANFNGLAHQQQQEA

Gene
dohh
Protein
Deoxyhypusine hydroxylase
Organism
Danio rerio
Length
305 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
33.919 kDa
Sequence
MANDKDIAAVGSILVNTKQDLTTRFRALFTLRNLGGAEAVKWISEAFVDESALLKHELAYCLGQMQDESAIPTLEAVLKDTNQEPMVRHEAGEALGAIGNPKVLELLKKYAEDPVIEVAETCQLAVKRLEWLMNGGEQTKDGTDENPYCSVDPAPPAQRKSVPELRTQLLDETLPLFDRYRAMFALRNLGTEEAVLALGDGLQCSSALFRHEIGYVLGQIQHEASIPQLQAALEKMDENAMVRHECAEALGSIGKEPCVQILERYRKDQERVVKESCEVALDMLEYENSSQFQYADGLLRLQSAH

Gene
dohh
Protein
Deoxyhypusine hydroxylase
Organism
Xenopus laevis
Length
303 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
33.385 kDa
Sequence
MAASLSSEVHSLGQLLIDPGKPLPLRFRALFTLRNLGGAEAIDCIGRGFQDESALLKHELAYCLGQMKDRRALPVLKQVLQDRQQEPMVRHEAGEALGAIGDPEVLELLREYAQDPVIEVAETCQLAVSRIEWLQKNPDSPDTNPYLSVDPAPPAEEKDVPTLRATLLDETCPLFHRYRAMFALRNIGGEEAVLALADGLQIGGSLFRHEIGYVLGQMQHKAAVPGLSAALERFEENPMVRHECAEALGSIAHEDCLKALRAHVGDGERVVRESCEVALDMHDYENSGDFQYANGLSQICEQI

Gene
DOHH
Protein
Deoxyhypusine hydroxylase
Organism
Bos taurus
Length
303 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
33.261 kDa
Sequence
MVTEQEVEAVGQTLVDPGQPLQARFRALFTLRGLGGPVAISWISRAFDDDSALLKHELAYCLGQMQDRRAIPVLLDVLRDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSTDPVVEVAETCQLAVRRLEWLQQHGGESAVRGPYLSVDPAPPAEERDLGQLREALLDEARPLFDRYRAMFALRDAGGKEAALALAEGLRCGSALFRHEIGYVLGQMQHEAAVPQLAAALAQPTENPMVRHECAEALGAIARPACLAALRAHVADPERVVRESCEVALDMYEYETGSTFQYADGLERLRSPLS

Gene
Dohh
Protein
Deoxyhypusine hydroxylase
Organism
Mus musculus
Length
302 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
32.905 kDa
Sequence
MVTEQEIEAIGKTLVDPKQPLQARFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDARAIPVLADVLQDTSQEPMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEVAETCQLAVGRLEWLQQHPGEATCAGPYLSVDPAPPAAEQDVGRLREALLDEARPLFERYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLARTTESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVALDMYEYESSQDFQYADGLERLRPPP

Gene
Dohh
Protein
Deoxyhypusine hydroxylase
Organism
Rattus norvegicus
Length
302 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
33.077 kDa
Sequence
MVTEQEVEAIGKTLVDSTQPLQARFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDPRAIPVLVSVLQDRNQEPMVRHEAGEALGAIGNPKVLGLLKQYSTDPVVEVAETCQLAVRRLEWLQQHPGEATCAGPYLSVDPAPPAAEGDVGRLRETLLDEAQPLFERYRAMFALRNVGGKEAALALAEGLKCGSALFRHEVGYVLGQLQHEAAVSELAATLARTTESPMVRHECAEALGAIARPACLAALREYITDPERVVRESCEVALDMYEYENGQDFQYADGLERLRPPP

Gene
DOHH
Protein
Deoxyhypusine hydroxylase
Organism
Homo sapiens
Length
302 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity).
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
32.904 kDa
Sequence
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS

Gene
DOHH
Protein
Deoxyhypusine hydroxylase
Organism
Gallus gallus
Length
299 amino acids
Function
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine hydroxylase family.
Mass
32.875 kDa
Sequence
MVTEEEVTAIGRTLLDAAQPLPARFRALFTLRNLGGPAAIDCIVRGFADSSALLKHELAFCLGQMRDRAAIPALLGVLQDSQQEPMVRHEAGEALGAIGDPEVLDVLRRYSEDPVVEVAETCQLAVRRLEWLQEHGEEPGSSPYRSVDPAPPAEETDVATLRAVLLDESRPLFDRYRAMFALRNLGGRDAVLALADGLRAGSALFRHEIGYVLGQMQDEACVPQLTAALRSRAENPMVRHECAEALGSIARPSCLETLRAFAQDEERVVRESCEVALDMYEYENGPQFQYADGLCRLQA