Protein
Serine/threonine-protein kinase Doa
Organism
Drosophila melanogaster
Function
Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Sequence
MVAANLEVPTSSSSSAATKRQKDVDNKLEKCLNDMLKLKTSSNNNSTSNSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYIGESQIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQQQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRERSHSLSR