About Products Protein Database Contact

Defa4

Gene
DEFA4
Protein
Neutrophil defensin 4
Organism
Homo sapiens
Length
97 amino acids
Function
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
Similarity
Belongs to the alpha-defensin family.
Mass
10.504 kDa
Sequence
MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD

Gene
DEFA4
Protein
Neutrophil defensin 4
Organism
Pan troglodytes
Length
97 amino acids
Function
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).
Similarity
Belongs to the alpha-defensin family.
Mass
10.504 kDa
Sequence
MRIIAILAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD

Gene
Defa4
Protein
Alpha-defensin 4
Organism
Mus musculus
Length
92 amino acids
Function
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
Similarity
Belongs to the alpha-defensin family.
Mass
10.272 kDa
Sequence
MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPGEEDQAVSISFGGQEGSALHEKSLRGLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR