Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Similarity
Belongs to the dUTPase family.
Sequence
MTDAEQTIKNQKTQEAEQSLRVFLRSENATLPTRGSVLSAGYDIYASEEAVIPAQGQGLVGTDISVAVPIGTYGRVAPRSGLAVKHGISTGAGVIDADYRGEVKVVLFNHAQKDFTIQKGDRIAQLVLEKIVMADIKQITAEELDITARGEGGFGSTGKN