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DUS2

Gene
DUS2
Protein
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Organism
Homo sapiens
Length
493 amino acids
Function
Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616).
Similarity
Belongs to the Dus family. Dus2 subfamily.
Mass
55.05 kDa
Sequence
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQYSTKGGMGAALLSDPDKIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQHPVSCEVIKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSREICEAFGLGAFYEETTQELDAQQARLSAKTSEQTGEPAEDTSGVIKMAVKFDRRAYPAQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFSSIVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQGLPEGRLGEESPSLHKRKREAPDQDPGGPRAQELAQPGDLCKKPFVALGSGEESPLEGW

Gene
Dus2
Protein
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
Organism
Mus musculus
Length
493 amino acids
Function
Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR.
Similarity
Belongs to the Dus family. Dus2 subfamily.
Mass
55.325 kDa
Sequence
MIVNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMLQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQSRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSDPDKIEKILSTLVKGTHRPVTCKIRILPSLEDTLNLVKRIERTGISAIAVHGRNRDERPQHPVSCEVIRAIAETLSIPVIANGGSHDHIQQHVDIEDFRQATAASSVMVARAAMWNPSIFLKDGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSQEICEAFGLGAFYEETIRELDARRADLLAKTPEAVEEPAEDTSGIIKMAIRFDRRAYPPQITPKMCLLEWCRREKLPQPVYETVQRTIDRMFCSVVTVAEQKYQSTLWDKSKKLAEQTAAIVCLRSQGLPEGRLGEESPSLNKRKREAPDQDPGGPRVQEPALPGEICKKPFVTLDSSEENLLEGC

Gene
dus2
Protein
tRNA-dihydrouridine(20) synthase [NAD(P)+]
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
479 amino acids
Function
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
Similarity
Belongs to the Dus family. Dus2 subfamily.
Mass
53.147 kDa
Sequence
MGLLNYSNKVCLAPMVRIGELPMRLLALRYGANLVWGPEIVDKALLSGTPVERVVNDRINCIDFVKPPSNKVLFRVHPLEANRLIFQLGSASPELAVEAAKLVANDVAGIDLNCGCPKHFSVHAGMGAGLLKNQDRLVSILDALVNEIGKPYKISISCKIRLLETKEDTLKLVERICDTGVRAITVHCRTTPMRNTEPADRSYLSEIVGVCRNKDVSILVNGDVLSYNDGLDVIEKYGVDGVLIARAAERNVSCFRIEGPLSSFKVAEEFLKMALEVDNNFGNTKYCLNQIMQGSFRKNVRQLAQTAKTYEDLKKAFEIEYKHSDASSVCPTLEKEKSLVISFVDLPSFLESLLASNILKQLSRLHFTKIFAVSEEEDICKQLDDIHEKFLCHGIALSLISADNLASAIASAHLVICMEKDESIMNEAVCDQKITIRLPINSNTNEAVVECENKSMQSKHALDIIQERIKDLEEKAQVV

Gene
dus2
Protein
tRNA-dihydrouridine(20/20a) synthase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
334 amino acids
Function
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
Similarity
Belongs to the Dus family. DusA subfamily.
Mass
37.929 kDa
Sequence
MTKIFADSSINPLSVAPMMDHTDRHFRYFLRQLTRHTLLYTEMITAQAILHGDRQRLLNFSPEEKPVALQLGGDDPQLLAECARIGQDWGYDEINLNVGCPSDRVQSGNFGACLMAQPDLVAQCVSAMQKAVEIPVTVKHRIGIDHRDSYEDLVHFVEIVANAGCQRFTVHARKAWLQGLSPKENRTIPPLRYEDVYQLKKDFPQLLIEINGGITQTEQIQQHLSHVDAVMVGRAAYENPYLFATVDRDIYHKTNLVPSRAEIIERMLPYVEERLRHGDRLNQITRHLLSLFNGQPRAKFWRRTLSDSTLLASAGPELLQTALQAQKFPGVLVA

Gene
dus2
Protein
Probable tRNA-dihydrouridine synthase 2
Organism
Bacillus subtilis (strain 168)
Length
325 amino acids
Function
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
Similarity
Belongs to the Dus family.
Mass
36.99 kDa
Sequence
MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEFTNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDINMGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTHILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGLKLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPYKPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE