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DRE2

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Candida albicans (strain WO-1)
Length
411 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
46.144 kDa
Sequence
MTSSINILLLLHPTVVTDAQLVEQIKSKIYQSHNNNNNNNGGTTTTTTGTVNINLNQQIIDRVTKGIIELPYDYYDEIIYINPNNESQYREIPISLMQLIYKLLKSNGKFKGDLPLDQNLDVLMTGFIIEEEEKEKEENNLEGELVNVWVKPIPVDEPVVTLLKKKTTTSNTTTKKKSLPLFKKLNKDEINNSDKDINNDNITNNNNNNNNNKRKLVETKLTYFSSDDENSSDGSVSENDDIDDDDELIDENDLLNFNNNNNNNTNGGSLLSDKLITPRKCDISLNGGKKRKKACKDCTCGLKELEELEVSNQQNLQDQILGKLAQSATLEAIKIEERLKQQQQQQQQQKVKVKFTEEDLSEIDFTVQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGEVVKLDGFGEDI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
409 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
45.941 kDa
Sequence
MTSSINILLLLHPTVVTDAQLVEQIKSKIYQSHNNNNNNNGGTTTTTTGTVNINLNQQIIDRVTKGIIELPYDYYDEIIYINPNNESQYREIPISLMQLIYKLLKSNGKFKGDLPLDQNLDVLMTGFIIEEEEKEKEKEENNLEGELVNVWVKPIPVDEPVVTLLKKKTTTSNTTTIKKSLPLFKKLNKDEINNSDKDINNDNITNNNNNNNNKRKLVETKLTYFSSDDENSSDGSVLENDDIDDDDELIDENDLLNFNNNNNTNGGSLLSDKLITPRKCDISLNGGKKRKKACKDCTCGLKELEELEVSNQQNLQDQILGKLAQSATLEAIKIEERLKQQQQQQQQKVKVKFTEEDLSEIDFTVQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGEVVKLDGFGEDI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Paracoccidioides brasiliensis (strain Pb18)
Length
381 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
40.037 kDa
Sequence
MPPSQTPAQGSGRFLLLSPPSLSSHPEKLNAILGLHARESTDLQMLDRLALGLVSLPESTYDVVLLLTGADNTLAETYRLVSRGVLQGVVNSLKPGGKLRNRDNQIWGSGSDSAAGLGSSDGDGGGGEKMSSSEQAFRNEAILAGLVFDDRGELAKPDFGAQQAVPLKLGRKKNLGESAFGNGAVELPASNGVRVTTGATSSTTTTTTTTAAAAAATAATPTTTTTTTINSSTPSGVGFIDFSDDFGVPMVEETQDSDEELIDEEELLGEYDMGRHIVQPPECRPKAGKRRRACKDCTCGLSQKLEAEDRAKRANADKALETLKLRTNDLAEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)
Length
366 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.624 kDa
Sequence
MLPSQTPAQGSGRFLLLSPPSLSSHPEKLNAILGLHARESTDLQMLDRLALGLVSLPQSTYDVVLLLTGADNTLAETYRLVSRGVLQGVVNSLKPGGKLRNRDNQIWGSGSDSAAGLGSSDGGGGGGGGEKKSSSEQAFRNEAILAGLVFDDRGELAKPDFGAQQAVPLKLGRKKNLGDSAFGNGTVELPASNGVRVTAGATTTTPTTTTTTTINSSTPSGVRFIDFSDDFGVPMVEETQELDEELIDEEELLGEFDMGRPIVQPPECRPKAGKRRRACKDCTCGLSQKLEAEDRAKRANADKALETLKLGTNDLAEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)
Length
359 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.541 kDa
Sequence
MASTGRVLLLSPPSLSSHPEKLNAILGSHTRDRTDLQMLDRLVHGLVSLPASTYDIVLLLTGADNTLAEPYSLVTRDIIQQVVHSLKPAGKLRSQDNKAWGLRSSGNNSDDDNDNDELTFRNEAILAGLVFDDNGELLKPDVAAQQAVPLKLGRRKKEKERRHPSGNDVTNGKVNAPSSNGVNASTSTATATATTTTTTTPKTNPAPSGVGFIDFSDDYGVPMEEDPQGSDDELIDEDELLGEDDMGRPIVQPPECRPKPGKRRRACKDCSCGLSQKLEAEDKAKRATADKALETIMAPTMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Blastomyces gilchristii (strain SLH14081)
Length
359 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.541 kDa
Sequence
MASTGRVLLLSPPSLSSHPEKLNAILGSHTRDRTDLQMLDRLVHGLVSLPASTYDIVLLLTGADNTLAEPYSLVTRDIIQQVVHSLKPAGKLRSQDNKAWGLRSSGNNSDDDNDNDELTFRNEAILAGLVFDDNGELLKPDVAAQQAVPLKLGRRKKEKERRHPSGNDVTNGKVNAPSSNGVNASTSTATATATTTTTTTPKTNPAPSGVGFIDFSDDYGVPMEEDPQGSDDELIDEDELLGEDDMGRPIVQPPECRPKPGKRRRACKDCSCGLSQKLEAEDKAKRATADKALETIMAPTMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
359 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
39.648 kDa
Sequence
MANILLLLHPTVVTDQHLVENVKADIRKSVGDAHVEQHIIDRVTRGEVELTRNTYDKIIYINPNVHNRSIPASLMKLVYETLIDEGEFSGDLPTDQALDVLMTGFIVSDTNDQCWIKPKPIESVSIPLRRKGKKTDASVSASSGTTALPLFKKLSSNSNNNNNSSSPIGLTDSSAANTDEETDEANVMKRKLDAAKLTYFSDSDSENEEDENDDIINEDDLIKDSNQLDLRSRLIIPKSCEIPNGKKRRKACKDCTCGLKEIEEQEEAQQRSLQDSILGKMAQSATLEAIKIEERLKRQPVKFKDEDLAEIDFTVEGKTGGCGSCALGDAFRCDGCPYLGMPPFKPGEIVSIDSLGEDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Botryotinia fuckeliana (strain B05.10)
Length
355 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.104 kDa
Sequence
MAPSVTIDNSSDFSPITTNFKTTSFNPRTLLLAPPSIASHEEKLRNVLATHDRTVTDLQMLDRLSAGLVTLPESTYDLVLILTDADGTRVESKGLLTRDVFGKITQALKAGAKLQAQDGTFGQEIDGAEYQEAILSGLVAEGGVMLKPDYSASVAVPLRLRRKDNSKNAAVSSAGPAVSMAAVPLHGKRKSVDMTDDVPEKDVPKVDSPKNDAPKGVGFIDFSDDFDAEDDDDELIDEDTLLTEEDMKKPLAIPPECAPRAGKRRRACKDCTCGLAEKLAKEDADKRATADSQLQALKLDADDLAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGMPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Length
351 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.272 kDa
Sequence
MATTGRVLLLSPPSLSSHPEKLNTVLKSHTRDKTDLQMLDRLAHGLVSLPESTYDIVLLLTGADNTLAETHSLLNRELIQRVVHSLRPAGKLRNRENKPWGLSDGNGNNANSSRRYNDDEQRFRNEVILAGLVFDDKGELLKPDIGAQQAIPLKLGRRKKEKEKTDTLASSANYITNGTVDAPASNGISAPIPAAKTTENNPVPPGVGFIDFSDDFGVPAEDDLEDSDEELIDEDELLDEDDMGRQIVQPPECRPKPGKRRRACKDCSCGLSQKLEAKDKAQRATADKALETMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ajellomyces capsulatus (strain H143)
Length
351 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.363 kDa
Sequence
MATTGRVLLLSPPSLSSHPEKLNTVLKSHTRDKTDLQMLDRLAHGLVSLPESTYDIVLLLTGADNTLAETHSLLNRELIQRVVHSLRPAGKLRNRENKPWGLSDGNGNNANSSRRYNDDEQRFRNEVILAGLVFDDKGELLKPDIGAQQAIPLKLGRRRKEKEKTDTLASSANYITNGTVDAPASNGISAPIPAAKTTENNPVPPGVGFIDFSDDFGMPAEDDLEDSDEELIDEDELLDEDDMGRQIVQPPECRPKPGKRRRACKDCSCGLSQKLEAKDKAQRATADKALETMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKQGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
351 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.202 kDa
Sequence
MATTGRVLLLSPPSLSSHPEKLNAILKSHTRDKTDLQMLDRLAHGLVSLPESTYDIVLLLTGADNTLAETHSLLNRELIQRVVHSLRPAGKLRNRENKPWGLSDGNGSNANSSRRYNDDEQRFRNEVILAGLVFDDKGELLKPDIGAQQAIPLKLSRRRKEKEKTDTLASSANYSTNGTVGAPSSNGISAPIPAAKTTENNPVPPGVGFIDFSDDFGVPAEDDPQDSDEELIDEDELLDEDDMGRQIVQPPECRPKPGKRRRACKDCSCGLSQKLEAKDKAKRATADKALETMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
350 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.728 kDa
Sequence
MAPSVTIDNISDFSPITTTTKTTSFNLRTLLLAPPSIASHEEKLRNVLATHDRSVTDLQMLDRLSAGLVTLPESTYDLVLILTDADGTRAESTELLTRDVFGKITQALKTGAKLQAQDGTFGQEIDGAEYREAILAGLVTEGGVMLKPDHSASVAVPLRLRRKDNSKTTAVSNAGPPVSTVEVPVSGKRKSVDMTEDVPEKDVPKNDVPKGVGFIDFSDDFDAEDDDDELIDEDTLLTEEDMKKPLAIPPECAPRAGKRRRACKDCTCGLAEKLAKEDAEKRATADSQLQALKLDADDLAEVDFTVKGKVGSCGNCSLGDAFRCDGCPYIGMPAFKPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.523 kDa
Sequence
MSGEKSSLLLIHPAVTTTPELVESVKKSNVFADSSKLDQFLVNKLNDSSVQLEDEKYSLVYYLTPEKESEIQFPTKLIAVLAQSLRGGGRLFGLSDVYKIDALINGFEVVNSGEQGYHWVKKGTAHTQTAPVALRPKRNTPSGGSKSLPIFAKPSFALPAFKKAEKPKPTGLPTFKKPESPRASVVAEDLDDGDELDGMNEDDSNSDELTASKSKFFDDVAGQDSADSIDEDDLVDDAEKSAITVVTCGKTKTRRRKACKDCTCGLKEAEAQEADAARAAQDRILGKPVKFDEQELTEIDFTIQGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPISLDTIADDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.523 kDa
Sequence
MSGEKSSLLLIHPAVTTTPELVESVKKSNVFADSSKLDQFLVNKLNDSSVQLEDEKYSLVYYLTPEKESEIQFPTKLIAVLAQSLRGGGRLFGLSDVYKIDALINGFEVVNSGEQGYHWVKKGTAHTQTAPVALRPKRNTPSGGSKSLPIFAKPSFALPAFKKAEKPKPTGLPTFKKPESPRASVVAEDLDDGDELDGMNEDDSNSDELTASKSKFFDDVAGQDSADSIDEDDLVDDAEKSAITVVTCGKTKTRRRKACKDCTCGLKEAEAQEADAARAAQDRILGKPVKFDEQELTEIDFTIQGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPISLDTIADDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Saccharomyces cerevisiae (strain RM11-1a)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.455 kDa
Sequence
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMATEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEGKEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Saccharomyces cerevisiae (strain JAY291)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.543 kDa
Sequence
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEENEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.455 kDa
Sequence
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMATEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEGKEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
38.455 kDa
Sequence
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMATEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEGKEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
348 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death.
Similarity
Belongs to the anamorsin family.
Mass
38.543 kDa
Sequence
MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEENEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
345 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
35.764 kDa
Sequence
MTPPVATDAAFSHSSNGVVLSTSVDPSGTVLVIGSMTSAQSGAYQKAVEAYSGRQVEMHMVDRLTDGATSLSANTYPLAHLAVNYAEAASPVLLSSLHSALQPKAKLIVEAAELVDASTAQKVKAELIIAGFTDIQVDVATGSVSASKPATASSSFSIGSSSGSSSALPLRRKLGSGASANAKKSLWATQPASANDLIDEASLLRDADFVATTAVKRPDCDVGAGQGKKKKACKGCTCGLRELQEEEKRTANTNIVQLDTDDMDMPNADTPATTKRTEVIETIIGKDGKPKTIKRIQVDTKGATSSCGSCFLGDAFRCSSCPYLGLPAFEPGQKVEIPVGMDDDI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
Length
345 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
36.49 kDa
Sequence
MPPAAVMIDTTPDFDFSPAHAAAAASAKGDSGDRTLLLAPPSIASREDRLTSLFSVYDRSSTDLQMLDRLAAGLVSLPAKTYDLILVLTDPDGSRRSEVSPLLSNREIWGKVVPALKAGGTLRSEDGSLGQGNSIEEKEAILAGLVLGDDGYTKPDYAEQEVVPLRFGAKKVNADGSVPLSFGKKAAAAPAPAPAPAPVSKGPAGVGFIDFSDDLDLDAEDDDDVIDEDTLLTEADLKRPIQQPPECAPQPGKKRRACKDCTCGLAERIAAEDKARREKAEKGLATLKLKSEDLSELDFTVQGKTGSCNSCYLGDAFRCADCPYIGLPAFKPGEQVKILNNTAQI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
343 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.761 kDa
Sequence
MTVSRDSLVLIHPAVTQQPELLETIEKGSILSETTIVAQYLINKLNDGTISPDDEKYDVIYYVTPEKPEAIQFPPKLIPVLHKTLKPSGRLYGLSDTLKVDALINGFEIVSNNGSEYYWVKESREKKAPVSISLKGNMKNGASAPVALPSFKKLNKTQPIGSSPSAGLAVSLKKLPTFKKLTKKVSAIKLTDSDLEDDDDDLESDDSANNSKTKFFDDFDDPETGDSIDEDDLIAETEEDTITMIQCGKSKQRRRKACKDCSCGLKEMEEQEIESRRAKQQQVIKFSEEELTEIDFTIEGKKVGGCGSCALGDAFRCSGCPYLGLPAFKPGQSINLNSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
343 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.761 kDa
Sequence
MTVSRDSLVLIHPAVTQQPELLETIEKGSILSETTIVAQYLINKLNDGTISPDDEKYDVIYYVTPEKPEAIQFPPKLIPVLHKTLKPSGRLYGLSDTLKVDALINGFEIVSNNGSEYYWVKESREKKAPVSISLKGNMKNGASAPVALPSFKKLNKTQPIGSSPSAGLAVSLKKLPTFKKLTKKVSAIKLTDSDLEDDDDDLESDDSANNSKTKFFDDFDDPETGDSIDEDDLIAETEEDTITMIQCGKSKQRRRKACKDCSCGLKEMEEQEIESRRAKQQQVIKFSEEELTEIDFTIEGKKVGGCGSCALGDAFRCSGCPYLGLPAFKPGQSINLNSISDDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
341 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.223 kDa
Sequence
MNTLLLLHPTIVTEPQAVEAAKDSLAQKLGTDKSNISQHIIDRVATGQVSLRPSYYNHIQYLAPPEANVKKLPVKCYEIIFEALQSNGVFEGTIPPESATDGILQGFLVESDTKWVKPSTLGSVVSLKRPAGQNKTKSSAFKKEMPFFKKLSSPPTLTDSSEADEDEESQLNEKLKGSKLIYFDESSDDEIIDEDELLRDDDGALKGPVVVPVKCALPNGKRRKKACKDCTCGLKELEENEQNERLDAQASILSKLATSANAEAEKIEERLRRKQASKEGEEVKFTEQEVTEIDFTIQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGQAISIEGLGADI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
341 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
37.223 kDa
Sequence
MNTLLLLHPTIVTEPQAVEAAKDSLAQKLGTDKSNISQHIIDRVATGQVSLRPSYYNHIQYLAPPEANVKKLPVKCYEIIFEALQSNGVFEGTIPPESATDGILQGFLVESDTKWVKPSTLGSVVSLKRPAGQNKTKSSAFKKEMPFFKKLSSPPTLTDSSEADEDEESQLNEKLKGSKLIYFDESSDDEIIDEDELLRDDDGALKGPVVVPVKCALPNGKRRKKACKDCTCGLKELEENEQNERLDAQASILSKLATSANAEAEKIEERLRRKQASKEGEEVKFTEQEVTEIDFTIQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGQAISIEGLGADI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)
Length
334 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
36.814 kDa
Sequence
MASTKTGLVLIHPGATEDPSSVVNAQEQARSEGVSVEAQFLINKINDGSVKLEDNHYDEVRYVTPEASDEIRFPSKLIGVIGKSLKTNGKLYGLSDLYKLDALINEFEISRSENHYCWIKKASIKAEPVAVPLRNHKKTTTPGTTTTAKKSLPIFKRATDNDSTKNKQQKQQHTGPARVSLDSEDEDEESEGSSDPSDSKSKFFEKSGSPLTENDSIEEDELVDENEMREPSLTMITCGKSKTRRRKACKDCTCGQKEIEEEELDGVRKQQDKVVKFSDQELTEIDFTVQGKKVGGCGSCTLGDAFRCSGCPYLGLPAFKPGQQIDLSSMGDDL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
333 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
35.409 kDa
Sequence
MSPITLDLTSDFNPANTTGAGSSSSQPRTLLVAPPSVASHEERISALFSTYPRDTTDLHMLDRLAAGLVTLPTSTYDLILVLTDPDGSRHAEASALLSNRAVWSLLVPALKAGGKLRSEDGTLGRDTTTPEAREAVLAGLVAGADGFTKPDYAEEEAVPLRFGLKRKTNPNPVVAPIQPVAQVVTAAPAGVGFVTLDLNDDLDLDGEDDDDDVIDEDTLLTEADLRRPIQQPPECQPKPGKKRRACKDCTCGLAERLEAEDKARRDKADQALNTLKLKSEDLLELDLTVPGKTGSCGSCALGDAFRCAGCPYLGLPPFKVGEEVSILNNVPQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
329 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
36.704 kDa
Sequence
MAVLLLLHPTVVTDPALAEASKKKWIQNDEEVTQHIIDRVANNIVEVPQNHYSKVVYINPNEAQHRGLPAQTIEQIFGFLKPEGKFCGDLPIDQNLDAIMSGFVVEDEHWLKPKPMASVAIPLRKKEKTDKNEPKKLPIFKKLNQDPGMTDTSASNTDEEETAIKRKLEESKLSYFSDDSDGEDDLVNEDELIDNSGLNYNLVVPKKCELPNGKRRRKSLLKIVLCGLKEVGGRAKDNRQRTLQDQILGSMAQLATKEAIEIEKRLAKSVKFTEDELTEVDFTVQGKTGGCNSCALGDAFRCDGCPYLGLPPFKPGEAITIDGIDEDWS

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
327 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.228 kDa
Sequence
MSPATVTIDTTPDFSNGGAPHSTLLLAPPAMAAQQDAMAAALTDAAPLGSRPELYMLDRLAAGLTNLAPAAYDLVLVLASGADPLLSRRDVFAKIADAMKPGAKLRSRDGSPLDAAIAKEAILAGLVESAEGAYEKPAEEVAAVPLKFLKKKNKGEGGGPVQSPAAATQPTAPAPAAAAKSLPNGVVMVDLNDDFDVSDDEMIDEDELMTEEDLMRPIQQPPECAPKPGKKRRACKDCTCGLAERLEAQDKARRDKADKQLQEKAATPFKLASEDLNELDFTVQGKTGSCGSCALGDAFRCADCPYIGLPAFKPGEEVTILNNVAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
327 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.228 kDa
Sequence
MSPATVTIDTTPDFSNGGAPHSTLLLAPPAMAAQQDAMAAALTDAAPLGSRPELYMLDRLAAGLTNLAPAAYDLVLVLASGADPLLSRRDVFAKIADAMKPGAKLRSRDGSPLDAAIAKEAILAGLVESAEGAYEKPAEEVAAVPLKFLKKKNKGEGGGPVQSPAAATQPTAPAPAAAAKSLPNGVVMVDLNDDFDVSDDEMIDEDELMTEEDLMRPIQQPPECAPKPGKKRRACKDCTCGLAERLEAQDKARRDKADKQLQEKAATPFKLASEDLNELDFTVQGKTGSCGSCALGDAFRCADCPYIGLPAFKPGEEVTILNNVAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
325 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
35.861 kDa
Sequence
MTLGDRLGLILIHPAVTTVPGLLEAKKLELSKKNYVIGDQFLINKLNDNSVTLEKDKYDLIYYLTPEKVEDIKFPVKLIPVIQSALKTNGSFYGLTEAFKVDALVNGFEIVSVEDNDYHWIKKAGSANANVVQLKTKKKLGNEVKSGKLPTFKSKLPTFKKKDAGNNEQVVKLSVEDVEDDLDDDPEVSNELLSKAKFFNSLSLNQDAEIDENNLIKSTDGDGITMITCGKTNTKKRRACKDCTCGMKELEEEEIDNIRTQQDKVVQFTSEELTEIDFTIEGKLVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPISLSSISDDL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
324 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
35.425 kDa
Sequence
MAPSFVTIDTTPDFDMAPAPSFQPMSTGSPSKRTLLLAPPSIATQEEKLRDLFTAFDRSTTDLQMLDRISAGFVSLPANTYDHILVLTDTDGTRRSEALHLLTRDVYTALVPCMKAGAKLQTQDNFFGEAEEREAVLAGLIKTDAGFEKMDQPKSFAIPLRRNGKKKDAAKTETFAPAPAPAPPVQPVTVGMINNDDDYENDDDLIDEDTLLSDEDLKRPIQPPECQPKPGRRRRACKDCTCGLAARLEAEEQAEREKADKALNVMKLETEDLNELDFTVQGKTGSCGNCALGDAFRCAGCPFIGLPAFKPGQEVQILENVAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)
Length
321 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.958 kDa
Sequence
MNNTAHSMSEKVLLVASLEAARYGQYQQAVKGLQAESGLLETHMIDRITDLAYAPPADYFDAVYMMLPSEGVEWAAALPKLRASMIPGAKLRVSVVNENDPSSFLSQVRAELTIAGFTDIQTYENASIESRRPASSSVAEKDSTASSGMGAVKLRRKPNENGGHQQKKALLWATQPETHMDTEAKLQEHARTVSPASRREDCTVDFSAPRTRRKRACKGCTCGLRELEEEDERNSNLVQLDPSEVGGTGGKRTEVTTTVKGPNGEEHTVRRIQVDTRGATSSCGSCFLGDAFRCSSCPYLGLPAFEPGQKVEIPANMDDDL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
320 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
34.492 kDa
Sequence
MAKQTLLLSPPSLSSQPGKLNETLQSYNRNATDLQMLDRLALGLASLPDSTYSTIVILAGGDNSFSESLKLINRQTFNQIIGSLRRGGYIYGQDAVSGVAFDHNEAILAGLIHVGNGKYLKPDIEEMQAVPLRLGRKNDHLAGAPSLEGSAAEHPFPPEVSEGKTASGDNRVAVVGSQKFRENIVSAATMDNNEASDDELINEDNLLDDSELSAPIIQPPECRPKAGKRRRACKDCTCGLAQKLQEEDAVKRADADEQLDAMKLLHDDLAEVDFTVRGKVGSCGNCSLGDAFRCEGCPFIGLPAFQPGEEVRLLNNDVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Uncinocarpus reesii (strain UAMH 1704)
Length
317 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.006 kDa
Sequence
MERMLFLSPPSLAAHPEKLSTILSAHAQYSTELQMLDRLAAGLVSLPESTYDIVMFLIDADCLKTGSTPRMSRGVIESIVRALRPGGKLKSEHGLFASPDYPDRTELVLAGLVFDDNGDLVKPNFGAQDTVPLKLGKKKKATPAASSGDGAEANGVTVNMPIATDSKRNGQGAAVQGLGFVDFSDDLDLPPEDDDELIDEEALMDEEDMGRPIVQPPECRPKAGKRRRACKDCTCGLAERLHEEDTAKRANADAALETLKLGSNDLAEVDFTVQGKMGSCGNCALGDAFRCDGCPYIGLPPFKPGEEVRLLSNDVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)
Length
317 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
34.372 kDa
Sequence
MAPSFITIDANDMDVDFSTTKPVQAKRTLLLAPPSIATQEDKLRDLFSTFDRSTTDLQMLDRLSAGVVSLPATTYDLVLILTDTDGTRRSEALQLLTRNVYTTLVPAMKAGAKLQTQDSALNASDAMEAVLAGLVQSDNGFEKPNFEPSAAVPLKFGLKKKNKPTPTAVPSIPTGFAAPMGIDSPVTNHDRDEDDELINEDTLLSEEDLTRPIMPPPECQPKTGRRRRACKDCTCGLADKLEAEDKERRANADKELNVMKLDTGDLNELDFTVEGKTGSCGSCALGDAFRCDGCPYMGLPAFKPGQEVQILNDVAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)
Length
316 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
33.502 kDa
Sequence
MSPSMPVATTVAADPIAVGAVAVKRPALVIGSLSTAEDGTYQALISDLQSSRQVDRQLLDRLVDNATTLEPSSYDSVHITLAPSDYQGLTQKLPQLLSQLLTGLTPLGTLHLINLTSAVRTLPSELTLAGFNVLSALPDEGTIIAQKPQHVASTSVPLKSRQPGALLNRKKTDPAKKQALWALSSPSTPKIDPEALLTAEDKTRLTPACEPVRSSAPRRKKACKSCSCGLAELEEEERKLGKVVLLDGSQDGTAKEVSQDEKERLIIAAKAAPKATSSCGSCFLGDAFRCAGCPYLGLPAFKPGEKVEIDFGMDDF

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)
Length
316 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
33.502 kDa
Sequence
MSPSMPVATTVAADPIAVGAVAVKRPALVIGSLSTAEDGTYQALISDLQSSRQVDRQLLDRLVDNATTLEPSSYDSVHITLAPSDYQGLTQKLPQLLSQLLTGLTPLGTLHLINLTSAVRTLPSELTLAGFNVLSALPDEGTIIAQKPQHVASTSVPLKSRQPGALLNRKKTDPAKKQALWALSSPSTPKIDPEALLTAEDKTRLTPACEPVRSSAPRRKKACKSCSCGLAELEEEERKLGKVVLLDGSQDGTAKEVSQDEKERLIIAAKAAPKATSSCGSCFLGDAFRCAGCPYLGLPAFKPGEKVEIDFGMDDF

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI)
Length
316 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
33.86 kDa
Sequence
MPVSKSVSPPKRTLLLAPPTLASHSSALSSVLADYDRSVTDLQMLDRLSAGLVKLPSSTYDRVLILADASFMLGESLALMNRAVLGPVAEALKPNGRLQSQDGNSLEESTLSKEAVLAGLVASRGGFEKPDYGDNEGAVTLKFGLKKKNQPAPLADGSVPLNFKKKKPVEVKPVVPVVPAGVGFIDLSDDLDDDDLIDEDTLMTEEDLLRPINIPVECQPKAGKRRRACKDCSCGLAERLVKEDAEKRAEADKKLESVKLATDDLAEIDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPPFKPGEEVRLLNNDVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP)
Length
316 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
33.807 kDa
Sequence
MAPRCLLIGTPSIAAHPERLDQVYEIHHRSSTDLQMLDRIAAGLVNLPAATYDVVLLLADADGTTRESHKLFSRDVMNKVASALKIGGVLKSQAGPFQGAEKTEAILAGLTETEDGMAKPEQEEPVSIPLKFGKNKANGVSATNGTNGAVNPDGSVPLNLNRKRDQPEPVKPAGVGFVDFSDDLDDPIITGEDDDLIDEDDLITEADMARPVVQPLECQPKPGKRRRACKDCTCGMKEKLEAEDAAKRSSADKALNSLKLDADDLAEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPAFKPGEEVRLLNNDIQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Length
313 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.761 kDa
Sequence
MSITIDTSVDIDLPTPPQSNGSQKRNLLLAPPSVAAHEEKLRDVFSTFDRSSTDLQMLDRLSAGFVSLPPNTYDLVLVLTDAQSDEAVRLLTRDVYTALVPAMKAGARLQLQQGSLGASEGLEAILAGLVEKDGGFEKPVQEAAVPLKLGGRKKKDKTNGVNGVQNGVATNGASTNGVGMFDPAQNNDDELIDEDALLSDDDLKRPLPRPQNCVPETAKKRRRPCKDCTCGLASQLEEEDRAREAKAAQDLNILKLNTDDLNDELDFTVQGKTSSCNSCSLGDAFRCSSCPYIGLPPFKPGEEVKIMNDMVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
313 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.795 kDa
Sequence
MSITIDTSVDIDLPTPPQSNGSQKRNLLLAPPSVAAHEEKLRDVFSTFDRSSTDLQMFDRLSAGFVSLPPNTYDLVLVLTDAQSDEAVRLLTRDVYTALVPAMKAGARLQLQQGSLGASEGLEAILAGLVEKDGGFEKPVQEAAVPLKLGGRKKKDKTNGVNGVQNGVATNGASTNGVGMFDPAQNNDDELIDEDALLSDDDLKRPLPRPQNCVPETAKKRRRPCKDCTCGLASQLEEEDRAREAKAAQDLNILKLNTDDLNDELDFTVQGKTSSCNSCSLGDAFRCSSCPYIGLPPFKPGEEVKIMNDMVQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
313 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.79 kDa
Sequence
MTLRILLLLHPTVVSDQNLVESVKSKISAEHPNHSLDQQIINRITQGDVVLSNNTYDEIHYINPNDSQYLEMPILLIKLLNDLLTHDGVLRGDLPKDQNLDALMQGFVVGDDGSWIKPKPVETVLLLKKKKESNITSNSNNNDSSPREVGVNNTGNYTHAAMSTLASKKKIPMFKKLLDRSNEVKGNLASGTVKSPSPGLTDTSAQNTDEENENGNSMKRKLVETKLTYFSDSDSDNNEGRDLDDDDDDGQEDNDIYINENDLISELKSDNLIIPKKCELPQWGKGAERHVRTVRVGLKGVVKEAGAFRRQSG

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
313 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.79 kDa
Sequence
MTLRILLLLHPTVVSDQNLVESVKSKISAEHPNHSLDQQIINRITQGDVVLSNNTYDEIHYINPNDSQYLEMPILLIKLLNDLLTHDGVLRGDLPKDQNLDALMQGFVVGDDGSWIKPKPVETVLLLKKKKESNITSNSNNNDSSPREVGVNNTGNYTHAAMSTLASKKKIPMFKKLLDRSNEVKGNLASGTVKSPSPGLTDTSAQNTDEENENGNSMKRKLVETKLTYFSDSDSDNNEGRDLDDDDDDGQEDNDIYINENDLISELKSDNLIIPKKCELPQWGKGAERHVRTVRVGLKGVVKEAGAFRRQSG

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)
Length
312 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
34.23 kDa
Sequence
MSPAAILSDVPRVLLLSPPSLSSNPDKLAELLNQYDKNTRDLQMIDRLAAGLVSLPESTYNLVLLLTDIDGTSTESERLVGRDVLQQIARTLQPGGIMKYHDGLSAMIKEPARTEAILSGLIANDKGELVKPVFEEQSVLLPFSINRSQKSIKGININKSDQQPAILQKNIVTLTNNTNDIFNGLEGDDDELIDEDELINEDELERPIIQPPECRPKAGKRRRACKDCTCGLAQKLEAEDKRQRANADEKLSALKLNSGEIAEVDFTIQGKTGSCGNCSLGDAFRCDGCPYIGLPPFKPGEEVKLFDNDVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
310 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.963 kDa
Sequence
MSGRTLLLSPPSLSSQPERLNGILQSYDRKTTDLQMLDRLILGVVNLPDAAYSRIIILAGEEDSISESSKLTTRETFSHIARSLQKGGYICSQHEQQGQAFDHNEAVLVGLIPTDNGKFVKPDIEDMRAVPLRLGRKKHDKTISSNLAEPVRNHQASPTVAQDQAEDGFRYSSGRNIVTASAHETSDNEIIDEEDLLDGSELAAPIIQPPECRPKAGRRRRACKDCTCGLAQKLEEEDAMRRHAADKQLGAMKLSHGDLAEVDFTVQGKVGSCGNCSLGDAFRCEGCPFIGLPAFQPGEEIRLLNDDIQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
310 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.42 kDa
Sequence
MAPSFVSIDTTPDFDMTPTSSKSADSGKRTLLLAPPSIATQEDKLRTLFTTYDRSTTDLQMLDRVSAGFVSLPANTYDLVLVLTGTDGTRRSEALQLLKREVYAAVVPAMKGGAKLQTEDNFFGEAEDREAVLAGLVKKETGFEKMDVGNGAAVPLRLGRKKKAAPAPAPVVQPPPIISSDDNDLNDDELIDEDTLLSADDLKRPIVPPPECQPKAGKRRRACKDCTCGLAAQIEAEDRERREAADKSLNVMKLESDDLNELDFTVQGKTGSCGNCALGDAFRCDGCPFIGLPAFKPGQEVQILNDVAQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
310 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.42 kDa
Sequence
MAPSFVSIDTTPDFDMTPTSSKSADSGKRTLLLAPPSIATQEDKLRTLFTTYDRSTTDLQMLDRVSAGFVSLPANTYDLVLVLTGTDGTRRSEALQLLKREVYAAVVPAMKGGAKLQTEDNFFGEAEDREAVLAGLVKKETGFEKMDVGNGAAVPLRLGRKKKAAPAPAPVVQPPPIISSDDNDLNDDELIDEDTLLSADDLKRPIVPPPECQPKAGKRRRACKDCTCGLAAQIEAEDRERREAADKSLNVMKLESDDLNELDFTVQGKTGSCGNCALGDAFRCDGCPFIGLPAFKPGQEVQILNDVAQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Schizosaccharomyces japonicus (strain yFS275 / FY16936)
Length
309 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
33.361 kDa
Sequence
MTTTIVLASPNYAANESKFATSLAKFQANSTDASHQRDIHMIDRIAGNLASLTVNAYDRGLLFLDESTTLEEIKAILPKLFAAVHPGAALSVDGVFAKELADAFERESLLAGWMIESKGPFVLRRPAQVEAVPLKLSTKKSAGASVGVKLDFLFKKPEKQNTLSKNDVLKAAQEEEEGEDDLYDEDALVSDEETQLGKDVLAPPSTCSKPGKKKRCKNCTCGQREQDEAEAAAASAAAPKAVKLTDTMEIDFTELLKSKNAVSSCGSCYLGDAFRCSGCPYIGLPAFKPGEQVLISENRDKLSWMADDL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
307 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.043 kDa
Sequence
MTPVPVSVDTTADFAAPPTKTAPSTSTRTLLLAPPSIAAHEEKLRDIFATFDRASTDLQMLDRLSAGFVSLPAATYDLVLVLTDTDSARRAEALQLLSRDVYSALVPSMKGGAKLQLQDGTWNSAEGLEAILAGLVEKDGAFEKPAYQEAAVPLRLGGKKKKAPAPTEQPPVATGVGFVDGNDELIDEDDLLSDDDLKRPMQQPANCQPEKAKKRRRPCKDCTCGLAAEMEAEDKARQEKADKDLNVLKLQSTDLSDEVDFTVQGKTSSCNSCSLGDAFRCSSCPYIGLPPFKPGEEVKILNNMVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
Length
306 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.802 kDa
Sequence
MPSLPVLIDTTTEFDVSSPQNVTQKRSLLLAPPSIAAHEEKLRDIFTTFDRSVTDLQMLDRLSAGFVTLPASTYDLVLVLTDTNGARRNEALELLTRDIFNILTPSMKPSAQLQLQDGPFQANEGREAILAGLVEKHGAFEKPQYQEAAVPLRFGANKRKNKISPEPVKIESVGFVDNYDDDELINEDDLLDEEDLGKPVQQPAECQPETAKKRRRACKDCTCGLAAQLEAEDAERREKANADLNVLKLKTDELNDEVDFTVQGKTGSCNSCSLGDAFRCASCPFIGLPAFKPGEEVRIMNDMAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
305 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
32.596 kDa
Sequence
MAAPRTLLLCPPSLSAHPEALNKIYEIHDRSTADLQMLDRIAAGLVQLPAATYDVVLLLTDADGTTRESHKLLARDVASKVAGALKVGGILKAKTEAILAGLSESPNGMVKTEQVESVSIPLKFGKKKTNGVNGTNGAVNPDGSVPLNLNGKRNQPEPVKPVGVGFVDFSDDLDDPIITGEDDDDDLIDEDDLITEEDMARPVIQQCRPKAGKRRRACKDCTCGLKEKMEAEDAAKRTTADKALNTMKLGADDLDELDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPAFKPGEEVRLLNNDIQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Length
305 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
33.442 kDa
Sequence
MPSLPVLIDTTPDFDFAPAQDATQKRTLLLAPPSIAAHEEKLRDIFATFDRSVTDLQMLDRLSAGFVTLPASAYDLVLVLTDTNGARRNEALGLLTRDVFNVLTPAMKPSAQLKLQDGPFQATEGREAILAGLVENNGAFEKPQYQEAAVPLRFGLKKKNKVAPEPVKVESVGFVDNYDDDELIDEDDLLAEEDLGRPVQQPAECKPDIAKKRRRACKDCTCGLAAQLEAEDAERREKANAELNVLKLKTDELNDEVDFTVQGKTGSCNSCSLGDAFRCEGCPFIGLPAFKPGEEVRIMNDMAQL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
303 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
32.37 kDa
Sequence
MTHSRTALVLIHPATTTRPELLTAAKQHSSLSGANIEQHLVNKLNDGSLQLQDNSYDVIFYVTPEAADEILFPRRLIGVLAAALRAGGSLHGLYDKYQVDALLSGFDIVREPTYHWQKRAVTASAPVKLAPRQPVSAAGLPRFKRASAPSPAAVTPTLDEVPPAAVDPVKAALLDSAAGDAPIAENDLVVGHDSTPITLLTCGRTQTRRRKACKDCTCGLREENEKEISDTHARQEKLLLGDAVKFSEPELAEIDFTIEGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLSAISDDL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
300 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
Similarity
Belongs to the anamorsin family.
Mass
32.403 kDa
Sequence
MAKQTLLLSPPSLSSQPGKLNETLQSYNRNATDLQMLDRLALGLASLPDSAYSSIVILAGGDNSFSESLKLINRQIFNQIIGSLRRGGYIYGQDAVSGIAFDHNEAILAGLIHVGNGKYQKPDIKEMQAVPLRLGRKNDHLAGAPSLQESAAEHPCPPETMISASTMNSNEASDDELINEDNLLDDSELSAPIIQRGPAPECRPKAGKRRRACKDCTCGLAQKLQEEDAVKRADADEQLDAMRLLHDDLAEVDFTVQGKVGSCGNCSLGDAFRCEGCPFIGLPAFQPGEEVRLLNNDVQL

Gene
dre2
Protein
Fe-S cluster assembly protein dre2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
288 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit suc22.
Similarity
Belongs to the anamorsin family.
Mass
31.534 kDa
Sequence
MSSSVLVLTSPGFASKEESLKKVFDLIDNGASRELQMIDRVQSQLVNLPINRYDSVIAAIDDGAWSSTLGPILSQAFASVHPGGTLRVYSTADEADESFEMTALLSGWLIESKSPWILSRPNQVEAVPIKLSNKNGQSASKNKILDFLKSDKENLISGDDDQELIDEDELLDESAHDNVLKVPECKPEPGKKKRACKNCTCGLREMEEHESSKTSAQLEAVKLTDTTEVDFTEKLKSKNAVSSCGNCYLGDAFRCSGCPYIGMPAFNPGDTVILAENRDKMSWMADDI

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
280 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
29.017 kDa
Sequence
MSNLLVFDNSVVTDEALVANIMAQNQGASHQLLERIGTQVQLPANTYASIQVFTKSPQPVTLPASLLETLSGALAPGGALFGAVDGSQVMDFIMAGLAQDGDKWVKPAATGTTLLKKSGGGPKKFAFKRASPATAAPSTNGTNPAATVNLNSVVTLSMDDDDLMDEDDLMEDDTNLSMPIKIPAKCDPGPGKKRRKACKDCTCGLKEMEEQAKDAQLAAQNTVTLSAEDTAEIDFTVQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGEAVSIGGASDL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
112 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
12.722 kDa
Sequence
MEDKEELRKLLRSMMRKSTDPRTKMQDEYLTDEDKAIQRSERPPAKKRACKDCTCGLKEEQEVRTRSACGNCYKGDAFRCSGCPSLGLPPYEPGDVVSFSMDLSNEFQGEDA

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
112 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
12.722 kDa
Sequence
MEDKEELRKLLRSMMRKSTDPRTKMQDEYLTDEDKAIQRSERPPAKKRACKDCTCGLKEEQEVRTRSACGNCYKGDAFRCSGCPSLGLPPYEPGDVVSFSMDLSNEFQGEDA

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Enterocytozoon bieneusi (strain H348)
Length
103 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
11.764 kDa
Sequence
MTSSDEELKELLKQATTYKQDPRHRIPMVDRPSKILTQSNKCRENKARKCSNCTCNKNTNTNNTIYKSKCGSCHLGDPFRCSSCPYKGLPPFNEGDEINFDEL

Gene
DRE2
Protein
Fe-S cluster assembly protein DRE2
Organism
Enterocytozoon bieneusi (strain H348)
Length
103 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
Similarity
Belongs to the anamorsin family.
Mass
11.764 kDa
Sequence
MTSSDEELKELLKQATTYKQDPRHRIPMVDRPSKILTQSNKCRENKARKCSNCTCNKNTNTNNTIYKSKCGSCHLGDPFRCSSCPYKGLPPFNEGDEINFDEL