DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

588 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

65.838 kDa

MTTEGLVVPALSTQQDDSTFEFDKVCSKTVVRSHLGLPNDATDDQVIKRIREYYNISEICNFLKQKVEGHELDMIPKYKHVTLQFPDSLICDSASIVHELQRELGLMPRTEDSSEVKCSADSCCKTGKVESPLSQKLWILADTSYSSCCIDEVAAGHVNSDLVIHFGDACLNVVESLPAAYVFGKPSLKLDSVITQFKEIYANRDSKILIMADAPHTQSLNQLYNILKPEYPNLAYADLYLNPSSNASIIGYDPCPSQSSILNVLNRTIIGLDNGDIDTDIDTILLEHDLFHIEVPAVPRLLQLTTRFQSVTTFEPKSGLASQGPYPKLMRRYRYMHMARSAGTVGLLVNTLSLANTKTLINKIGQKIKEAGKKHYVFVVGKPNVAKLANFENIDIWCVLGCDHQGIIIDENNEYYKPIVTPYELLLALNKDQNWSGKWVTDFNKVLEDMSLEDERNKQEINDGSDNNEEDSDDEAPEFNPVTGQYVSTSKPLRKLHHLQISSQEQHPELDNEGSQDLVKKFSSAVAIKDTVSTSAMHLQTRHWTGLGSDFQQNDSDEEANNEDGALVEDGRAGIARGYDYDRETKFQ

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

588 amino acids

May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

67.193 kDa

MSAAPPPSIYTESFSTSSNNTTESESINVEETRENILSGFSFEEYFQVSESISVIIKNNFKKIALQLPDYLLWASSELSNKIQNSVPLEYGIKVFILGDTSYGSCCVDEVTSSHLKSDFIIHYGHSCLSPSSKIPVQYVFGKKKNFNVDKFSIELNKLVESKKEENFVIFYDLLYHHNRDSIENLYKNNDNIIVTNINNFNNIYLNNSFKNNKLNETQNCNNNYNNDCCGSDNNNNNNDSGCCGGNNNNNNNNSGCCQSQSQQQQQQNDCCQQKLNNEINNENDNNNEELISGRKIEFKNEKDIKKFNFIWIGEESLTLTNLLMNFNQQMVYRYYIDDNKLLQETLPRNKSLMRRYHISEKCKDASIIGIVVSTLSVQKYSETIDGLKKLIIASGKKPYVFVVGRLNVPKLANFSEIDIYVIVACHENTMVDSKDFYKPIATPFELNLSLRNEKWTGEYITDFGRVFPKLIKDLSFDEDDENKCEIPEDQVEDDQGNIHHFSLVTGRIVIQNKNQSTLQQQQQQQQTQQSGDLISVNNQFKQVSLVGEHLSNKTYKGLDMRIGETPVTTAIEGMSGIPKNYNTDKNNL

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

587 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

66.189 kDa

MNDSVLVAPSLSTAQTEDTFEFQSYGETEHSRSYLGSDVTKDNLVELVSAYYSVPELIQYFEEHPQYKKITLQFPDELVLDSSIVVQLMQQELVKAEDETSQSFNTIDTDEVLHNEKSCGNCSGCDCSSKIDKTETKRKVWILADTSYSSCCVDEVASEHVKGDIVVHFGDACMNAVQKLPVVYSLGRPVLDLDLVVSQFKLKYAAKDQKICLMADAPHSMHMKSIYDILHDKEGYKNVVYSDINQDMLQSDTHIVGYNNAVEHDERLRKCVTCGNRNIYAEVDVSELNEYDLFHVTIPKDPHLLYLTTKFQSVTLYDPSSGMLNEGPFPSMMKRYKFMHMARTAGTIGILVNTLSLRNTKETMNKLTKLLKENGKKHYLFVVGKPNVAKLANFEPIDIWCILGCGQGGIVLDQYNEFYKPIITPYELLMALSDEVTWTGQWITDFKSIINQIENEVNDSDDMEQDILSSGTECRSDEDEAPEFNAVTGKYVSTSRPLRQIARLEIETPVEEVRASDSTELVKQFSQTVAIRNTVSTSAAFLQTRHWTGLGSDYKDDEDGEEDGATVEEGTAGVARSYQFDELNKKT

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

582 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

63.662 kDa

MSEAALVPPALSTNQTEETFNFQQYELLRQDRAAHLGPGITDLASLKERIRSYYAIESLADHLNSHAEYRSITLQFPDDLLFDSALVAEELQALLPDLQCARTDAPAQADTTCSCGTQKTCADSKDSADGRKIWILADTAYSPCCVDEVAAEHVQADVVVHFGDTCLNPVETLPVVYIFGEPYLDRAKVISLFTERYDKDAKVCLMANAPYSRHLESLSGELSQLGYSNLVFTDVALPDTPNAAATILGVSDSHPISHKLYASGDRVYYGAKEQLLCEEQLQSFELFHIGLPPDPRLLFLSTKFQGVTAYDTQKRQIAKGPFPAMMRRYRFMHVARTASTIGILVNTLSLKSTRSLISSLVELIRSCGKKHYMFVVGKPNVAKLANFEPVDVWCVLGCGHGGIVLDHANEFYKPIVTPYELTLALAPELSWTGAWVVDFNTVIDGISADLGLQAGAIPAENVPEFDAVTGKYVGNSRPLRELNHLEIESPQESITTGSTELVKKFSGALTIGSTVSTSAQFLQARQWTGLGSDFNAEDSYEEEGATVEEGLSGVARGYQYDVSNAEHTDADVPKTSGRVMNT

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

582 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

63.619 kDa

MTTELAAAPVLSTPDDRILEETDPVVPQTNRILSEEELAITYDIERTLKEIRQARYKRIALQFPDEMLPDAPRVFQLLSRGLEARDIVDGGSKANTETEPTDGLVDSASRLDLKDADEWSPKLYILADTSYGTCCVDEVAAEHVDADVVVHYGRSCLSPTARLPVIYVFTHKELPLDPVLKAFKETYPDPETKVILAADVTYSDHIPEVYSRLVQEGYSSLFATALVHDPSSVIPNRTVPDSVKEAPESLGNWQLFHISEPPTALLLTLASRVAAIHIYPTDGPAGTDVKPLPASTAMVLRRRYAILTRLSTVPIFGILVNTLSVKNYLHIVDHVRDKIAAAGKKSYMFVVGKLNAAKVANFSEIGGWVVIGCWESSLVDSKDFWKPVITPFELEVALKGDEERVWTGAWQSDFQSILDQPPPSSNSPGNSQEANEGPEFGDHARDEDEDAMSEPESAPPEFDLRTGRYVSYSRPMRDSAPRVSASQGATAAISAQTGAADGPSAARALARRAKGDLAMVGNTFSPGAEFLRSQRTWTGLGSDFNSAANVEYDDEENDSTLVVQGRKGIARGYTVGDSIDRH

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

565 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

62.076 kDa

MATEMQAAPVLSTPDSLILEATEPVARQNATRTLSDEELSITYDIERTLQEIRQARYKRIALQFPDDMLPDAPRVFQLLSRGLACRDVDKITVEKNGNGTGGVESEKLAQDVSQLSVDDKPEPEPKLYILADTSYGTCCVDEVAAEHVNADVVVHYGRSCLSPTARLPVIYVFTHKELPIEPVIQAFKATYPDQATKIILAADVTYCDHIPAVYARLMEEGYTNLYATELIHCPSSAIPNRTVPDSVRENPDTLSEWQLFHISDPPTALLLTLASRVAAIHIYPTTDAPSDNVKPLPVSTSAALGRRYAILTRLSTVPIFGILINTLSVKNYLHIVEHVKQKIADAGKKSYMFVVGKLNAAKVANFSEIGGWVVIGCWESSLVDSKDFWKPVITPFELELALKGDHERVWTGAWQSDFQSILDQPAEEAQTADHEESPNDDDDMSEPESAPPEFDLRTGRYVSHTRPMRNPAPRVSAQSDDAVSAASGPAAARALARRAKGELAMIGGTVSPGAEYLRSQRTWKGLGSDFDIQYDDEDPSDSTLVVEGRKGIARGYTVGDSIEKH

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

551 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

61.807 kDa

MSNEDILVPAALSTHQDESDFTFQKFDSDSMERSFYLGPLSSQDELWDKLMQYYSIDKLIAYLQRNPEYVQITLQFPDTLVKDSSFIIRALQDKLDGDGAGRKFWALADTAYSACCVDEVAAEHVKGDLVIHFGDACLNAIQKLPVVYDFGKPFLDTDVLLACFTEEFKDKDQKICLMSNASYTHHIPDLYSRLKSNGYTNVVYSVVNTGLLTETAEIIDNTTPLSDTDELFTLGNRVLMGARQEEDIDEETLRNEYALFHITMPHDPHLLYLTTVFESIHTYDVADQVISNGPYPSLTRRYKNMHKARTAGCIGILVNTLSIRGTRETVNKLIKLIRENGKKHYLFVVGKPNVPKLANFEPVDIWCILGCGQSGIIVDEFGEFYKPIITPYELTLALNFEVTWTGKWIIDFQKAITEIDNSLAELGIDDSKHGNDSDHDLDAPEFDAVTGKYVSSSRPLRALNHLQLDAPSNEDKQVMARVNGGTVIKGTVSTAVEHLANRAWTGLGSDYKDDEGYEEDGATVEEGISGIARGYEFDQEDAARKSQNQSQ

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

535 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

58.587 kDa

MASELSSAPVLSTPDDHILEVPAADSIPTSTLSDDALRTTYEIVRTADEIRAGGWKRIGLQFPDFMLVDAPRVVEALSKEINTHDQEEAKPERRIYVLADSSYSACCVDEIAAEHVSADVVVHYGRTCLSPTSHLPAIYVYTTHDLDYEVTINEIKKEFSDKTVKLVIMADLTYQNHVDKVVSLLKEQGYNDAVSTEVTRDPAALIPNRKILSDETHDDEHWKAYSIIHISDPPSALLLALYTRFASLHVLSTPSPALENPTMRTAGLLRRRFAKVLALASAGVIGILVNTLSVANYLSSINTLRERIARADKKSYTIVVGKLNPAKLANFAEIEGWVVVGCWESGLIEDDAGYWRPVITPFELEVALMSEEERVWGGEWWGGIEKLGLNDKPEDASKESEGAVAEEEVEFEDVAGGVEGEESAPPEFDMRTGKLISSSRPMRLPVRKNPSTTAETEANSDGQPTSTQQNDSLIKRSVGELASINGVASPGAEFLRSGRTWQGLGTDFDNEASTLVEEGRSGVARGYEVGESGRH

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

534 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

59.775 kDa

MEVAPALSTTQSDVAFQKVETHEIDRSSYLGPCYNSDELMQLISAYYNVEPLVGYLEQHPEYQNVTLQFPDDLIKDSSLIVRLLQSKFPHGKIKFWVLADTAYSACCVDEVAAEHVHAEVVVHFGDACLNAIQNLPVVYSFGTPFLDLALVVENFQRAFPDLSSKICLMANAPFSKHLSQLYNILKGDLHYTNIIYSQVNTSAVEEKFVTILDTFHVPEDVDQVGVFEKNSVLFGQHDKADNISPEDYHLFHLTTPQDPRLLYLSTVFQSVHIFDPALPGMVTGPFPSLMRRYKYMHVARTAGCIGILVNTLSLRNTRETINELVKLIKTREKKHYLFVVGKPNVAKLANFEDIDIWCILGCSQSGIIVDQFNEFYKPIITPYELNLALSEEVTWTGKWVVDFRDAIDEIEQNLGGQDTISASTTSDEPEFDVVRGRYTSTSRPLRALTHLELEAADDDDSKQLTTRHTASGAVIKGTVSTSASALQNRSWKGLGSDFDSTEVDNTGADIEEGISGVARGYGFDREDAMKKENK

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

531 amino acids

May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

59.36 kDa

MEVETTAKSYDVPASAFSESAVIDTHLDVPSTKTESIERMVEVYEIERSVQVITSSGFNKVALQFPDSLLADSASVARLIEQRASCKAFILADTSYGRHPPLPANKTFLKLYNVRICFKLLAFLHFSSCCVDEIAAEHADAELIIHYGQACLSQTKRLPVLYVFGKNPINVIECSQHFRQLYPDTGIRVLVFYDVVYNHCIGALDEALSPLYPNMTISTIAPEGLPSEPTSQQSSRNPQASDVEGMEVNQCNRRFGRDFTLAANSSISDYQIFYIGEQSLTLRNLMMTYNKCQFSTYDPITNESRRETLNVNKALMKRYHMIQRAKDAQIVGIVVGTLGVADYLKIIERLKKVLAIAGKKSYVFVMGKLNVAKLANFLEIDVFVLVSCPENSLIDSKEFYKPVVTPYEMEIACLRTQEWTGDYVTDFHELLPGKSINTFWTDDNDDSPYISLITGKMQHNYKSSAKEAGETSTSLVQRNQETTLATQQPLTAEFLASRSWQGLQQNLGDTPVTTAVEGRRGIAAGYTDEGE

DPH2

Diphthamide biosynthesis protein 2-1

529 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

59.198 kDa

MTSETVIAPSLSTAQNDGTFTYDKVKSTAKERKHLNLKNPSDANEIKSKIWNYYSLSELIQYLGQKENDDFKYKRITLQFPDNLICDSATIVHELQRELNIVPQANQDTGESNTAQRVWILADTSYSACCVDEVAAEHVRSDLVVHFGDACLNEIDKLQAVFVLGKPTLDVDAIVKQIKTAYSTEQKVVLMSDAPHTYLLPEIAKQLPDYDILIADLPKTSRAKIIGYTPPPTGHKKFNRVFNTDTVEFGKYELFHITSPESPRLLQLTTNFASVTTYDPISGTVSTGPFPNLMRRYKYVHQARMAGTVGILVNTLSLANTKVLLNTIKEKIKEAGKKHYIFVVGKPNVAKLANFESVDIWCILGCDHQGIIIDQINEYYKPIVTPYELLLGLSDELSWTGKWVVDYKSVLEEYGNEVIQQNEDPDTDEDLPPVFDPVTGRYVSTSKPLRQINHLMVTSSEQGGVDDHDNQLVKRFSNAVAIKGTVSTSAIHLQNRHWTGLGSDYTEDENATGALVEDGRKGIARGYDI

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

515 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

56.464 kDa

MSDAFSTPADHALSHPELEAILENAQAGPSSIGDGAEGMSIEEAFEVDETVRRVLEGDYKTIGLQFPDELLPSSVSVYRAIQTRIAHTGAQAYVLADSTYGNCCPDVLSCLHLPADFLVHYGHACLTPTDALPVHYVFPRQKLDVKQAVESLLAASKNELDGDGRKGIVVVWDVSYDWLANDIRDTFSQDSTIQISFASIQKPTLASQKGLKDVKGKTPALRSVEPPQGLEMNDCVLWYIGEEGRSCMNLQMTHANNPLFIYSPSSQSVSPLHRTTSRLLSRRLFALHQALSADVFGLIVSNIGLASSKPLLAQLREDLKRAKKKSYTLSVGRLNPAKLANFAEIECFVLVGCAEGGVVDSKDFLRPIITPWELELALQGPDHVWAPENWTLDLGTVLKDAQEREIKIKQDSSTADSDDDSLEFSLITGTMRTKKRFAFGNGTHTLENNKLLGDGGVQDLTLRNQNFSLSKLESAGSTFLASREFQGLEPRYGMDEPSVLEQGRSGVARGYTEEK

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

515 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

56.464 kDa

MSDAFSTPADHALSHPELEAILENAQAGPSSIGDGAEGMSIEEAFEVDETVRRVLEGDYKTIGLQFPDELLPSSVSVYRAIQTRIAHTGAQAYVLADSTYGNCCPDVLSCLHLPADFLVHYGHACLTPTDALPVHYVFPRQKLDVKQAVESLLAASKNELDGDGRKGIVVVWDVSYDWLANDIRDTFSQDSTIQISFASIQKPTLASQKGLKDVKGKTPALRSVEPPQGLEMNDCVLWYIGEEGRSCMNLQMTHANNPLFIYSPSSQSVSPLHRTTSRLLSRRLFALHQALSADVFGLIVSNIGLASSKPLLAQLREDLKRAKKKSYTLSVGRLNPAKLANFAEIECFVLVGCAEGGVVDSKDFLRPIITPWELELALQGPDHVWAPENWTLDLGTVLKDAQEREIKIKQDSSTADSDDDSLEFSLITGTMRTKKRFAFGNGTHTLENNKLLGDGGVQDLTLRNQNFSLSKLESAGSTFLASREFQGLEPRYGMDEPSVLEQGRSGVARGYTEEK

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

503 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

55.635 kDa

MSFELSAPVPLSDNSEAILEKEIGETVKIEGDLVEVYEINRTVDFIKSGNYNSVALQFPDEHLADSGKVASILTNLVEANVQILADTNYGSCCVDEVAAEHMSADAIVHYGRACLSPTSRLPVLYVFGRLPINLHKLEKCLTIPLDQNILLVSDTRWYYAQDSILKSLKTLGYQNVYESHLKERIEPNLEEASTSYTIPGRTYSLPKSLSLQDMTLLYIGPDSPTLSSILMSHYSLVNQFLSFDPLSNKIVEESSFTGAKLRRRYALVQRCRDAGVIGIVIGTLGVHRYLHVLNQLRKMILNAGKKPYMLAVGKLNPAKLANFQEIECFVLIACGENSLIDSKEFYRPIVTPFELVKALSSDMSWNNDFILSFDEVLKLSEGKQSKEPSEVLTEESAEPHFSLITGKFVNSTPMRHLDVTLETADAKNNDSSSASIEKRGMRSLAVNGVYSPAAAFLQSKSWSGLDSVDEGEGPSKLYEGQSGIAKGYVGEGSKEKIQRDFGK

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

498 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

55.152 kDa

MTDAFSSSSEAVLQRSVTSTHSFHPSGDLLLLYQTPETCRFITSNHFKKVALQFPDELLPDAVRVSAEIEDKTKAKTYILGDTSYGSCCVDEVAAEHVGADCIVHYGSSCLSPCRRLPLLYVFGKRPIDVHQCASSFKELYPNLQSHIIVLFDVTYSHAIDDLRTLLCDVYPNVVVSRLKTDHSCGAELIQDSCVDLQSNDDGVIFKFGRQFRIKEGQTVNDYSIFYIGQEGLTLTNFMMSWNNCVFSSFNPETSTGRVESVQINKALMKRYYAIERAKDASVVGILVGTLGVANYLIIIEQLKDTIQRAGKKSYMFAMGKINVPKLANFLEIDIYVLVACPENSLLDSSEFYRPVVTPFEMELACNKHREWTGEYVTDFRELLPGGSSHVGFPEPSQSATEEETTDVSLITGALRSCSTNSSEMMHNSETSSLVLRNQTLTVANTNAAASFLAGRSWQGLEPKLGQTPVVKAVKGQRGIAIAYEEEGNEDASTQQKL

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.201 kDa

MESMFSSPAEAALQREAGMPGLLTPLPDLDRVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQAVIHFGPACLSPPARPLPVTFVLCRRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPLPVGSLSPEPKPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLVGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVPLPPSESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG

Dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.325 kDa

MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTRFICDLGCQRVALQFPDQLLGDAGAVAARLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSPPASLLPITFVLGRRPVALELCAKAFEAQNPDPTALVVLLSEPACAHALEPLATLLRPKYQDLLISSPALPLPVGSLSSQPESLERFGRRFPLNPGRSLEEYGAFYVGASQASSDPNLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLVERARDARVVGLLVGTLGVAQHLEALAHLRKLTEAAGKRSYVLALGKPTPAKLANFPEMDVFVLLACPLGALTLQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTKCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSS

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

51.795 kDa

MESTFSSPAEAALQREAGSAGLRTSLGDLDRVYELERVVGFVRDLGCQRVALQFPDQLLGDAGAVAALLEEATGSKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSPPARPLPVAFVLGQRSVALELCAKAFEAQNPDPTAPVVLLSEPSCAHALEALATLLRPRYLDLLVSSPALPLPAGSFNPNPEPLERFGRRFPLAPGRCLEEYGAFYVGGSEAISDPDLDPDLSRLLLGWAPGRPFSSCCPDTGRTQDEGVRAGRLRARRRYLIERARDARVVGLLAGTLGVARHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGTLAPQPSGSFFRPVLAPCELEAACNPAWPPPGLAPHLTHYTDLLPGSPFHVPLPPPDSELWDAPDVSLITGDLRPPPVWKPSDDPGCSALTPKPQLELAESSPAASFLSSRSWKGLQPSLGQTPVTGAVSGRRGIAIAYEDEGNS

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.072 kDa

MESTFSSPAEAALQREAGVPGLFTPPEDLDRVYELERVTKFVCDLGCQRVALQFPDQLLGDAGAVAVRLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAEALVHFGPACLSPPASLLPITFVLGQRSVALELCAKAFEARNPDPTAPVVLLSEPACAHALEALATLLRPKYQDLLISSPALPLPVGSPSSQPEPLERFGRRFPLSPGRCLEEYGAFYVGGSQASSDPVLDPDLSRLLLGWTPGRPFISCCPDTGQTQDQGVQAGRLRARRLYLIERARDAHVVGLLAGTLGVAQHREALAHLRKLTEAAGKRSYVLALGRPTPAKLANFPEMDIFVLLACPLGALAPQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFYVPLPPPESELWDTPDVSLISGDLRPPPSWKSSSDTGCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSG

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.083 kDa

MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPVAFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLGWAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILAPCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIAIAYEDEGSG

Dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

489 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.365 kDa

MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTKFVCDLGCQRVTLQFPDQLLGDAGAVAARLEEVTGAKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSPPASQLPITFVLGQRPVALELCAKAFEAQNPDPTAPVVLLSEPACAHALEPLAMLLLPKYQDLLISRPALPLPVGSPSSQPESLERFGRCFPLNPGRRLEEYGAFYVGASQASSDSSLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLIERARDARVVGLLAGTLGVARHREALAHLRKLTEAAGKRSYVLAVGKPTPAKLANFPEMDVFVLLACPLGALAPQPSGGFFRPVLTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTRCSALIPRPQLELAESSPAASFLSSRNWQGLEPRLGQTPVKEAVRGRRGIAIAYEDEGSS

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

481 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

53.569 kDa

MSQAPVLSTEPEFETVAPLVRETPSNDYLNKYYCLPQLTEYLNSHEYKSIALQFPANDVADSALVVRLLKQTVDPSISLFILADTNYSPCCVDVVGANHIKADLVVHFGSACLNPVTMPVVYVFCNPEIDVKVMVDQLTEQIKDAEQPNILLDSDSKYYPEMPTMFKALREAFPDKIIVRSFIPNPQETLGLSEEETKPDAEEGYLYRRTHDDLDPQETMLIYVGTPSSSLALHYSTRFGATAYFNPVSGQAETPKTAIMKRYRYMNMARAAQTIGILINSLSMSETKEMSKKLQKAIAESGKKSYTFVVGKPNVAKLANFEVVDVWAVFGCGIGGIILENEEQYFKPVVSVYELGLALQPELSWTGEWEIDSNKVDLNVEVDEDEVDEPFFNPVTGKFIDHKPLHVQEYSDDEETQALVKSIGGSLTIKNTVTTAAIQLQQREWQGLGHDYGSGEEDGADLEEGRGGIARGYAVGDDERM

dph2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

478 amino acids

May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.686 kDa

MAAALFSSNGEEAIGRNIDIGQVDIQSSPEKDLGEFYEIEKTVEFIQRNAAQKVALQFPDDLLLDSVKVARKLEEATGAKTYILGDTSYGSCCVDEVAAEHVKANVLVHYGRACLSPCCRLPVSYVFGRKAVNMDLCAEAFLSHYRDTESHVVVLSDVVYDHALGELAKRIRSAYPNVIFSKLTSCGETASPDEIVKFGRRFSPDLRLWPESYGIFYVGGEGSTLNNLMLTWPRCSFFSFNPFTGEGRTEGLHVNRALMIRFYLIERARDAHVFGILVGTLGVSDYLSALKHLKNIIHLAGKKSYMFSVGKLNPAKLANFPEIDVFVLVACPENSLLDSSEFYKPVVTPDEMEIACNPAREWHGYCITNFRELLPGGSAYVEFPETDPSDAHHTDVSLITGNLRSSHLTVAETLEKDSDTSLVQRNSKTALAQMSSAASYLASRSWQGLDKALGQTPVVKAVEGRKGIAIAYEDEICS

DPH2

2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

477 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH2 subfamily.

52.163 kDa

MAAAFSSDGEAVLRRTLDPAAAAPRGDKDEFYEVDRAAAFVRDGGFRKVALQFPDALLADAAAVAARMEEVTGAEMYVLGDTTYGSCCVDEVAAEHVSAGAVVHYGPACLSPCRKLPVLHVFGRQPLDVGRCAEVFRELYPERQSRVVVLSDVVYAHAMGELEKQLCHEYPNIIFSEVVCGDAPSPTLPGEVRQFGRRFHMEAAEELQDCSMFYVGAEGLALTSFMLTWNRFPFSSFDPATGHGRRETLNVNRALMRRLYLVERARDAHVVGILVGTLGVAGYLDVLEHLHQLVRRAGKRSYTLSVGKPNPAKLANFLEVDIFVLVACAQNSLLDSSEFYRPIVTPYELELACNPAREWTGNYLTDFRDLLPGACAHIELPPAVPAAEAIPDVSLITGEMRATHLCDPLAPQPPSSTTLACRDQTRALAEMSPAATFLESRSWRGLEQQLGKTAVSKAVQGRRGIAIAYEDEGREQS

dph2

2-(3-amino-3-carboxypropyl)histidine synthase

342 amino acids

Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

Belongs to the DPH1/DPH2 family.

38.464 kDa

MLHEIPKSEILKELKRIGAKRVLIQSPEGLRREAEELAGFLEENNIEVFLHGEINYGACDPADREAKLVGCDALIHLGHSYMKLPLEVPTIFVPAFARVSVVEALKENIGEIKKLGRKIIVTTTAQHIHQLKEAKEFLESEGFEVSIGRGDSRISWPGQVLGCNYSVAKVRGEGILFIGSGIFHPLGLAVATRKKVLAIDPYTKAFSWIDPERFIRKRWAQIAKAMDAKKFGVIVSIKKGQLRLAEAKRIVKLLKKHGREARLIVMNDVNYHKLEGFPFEAYVVVACPRVPLDDYGAWRKPVLTPKEVEILLGLREEYEFDEILGGPRESDEPFGISIHSTR

dph2

2-(3-amino-3-carboxypropyl)histidine synthase

340 amino acids

Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

Belongs to the DPH1/DPH2 family.

40.014 kDa

MLFKTIFYQKLQKKVTTLFNLETERVIREIENLNKNNPKVIFQAPEGLKLKVEKEIEKIKQYFKQKNINIEIYLWGNTCFGACDLIDNHVKNLNVDLIIHYGHEKLSYANPEIKTLFIPAYHIFNKDEEEKILNDIKNFIEKHKSGGKKVAIATTIQYKKLLKDFNPSIILGCRGEVKEGDVILFVGTGRFHPLMIAYKYQKEVFIYNPLSKCFDKISEEEINKFIKKRILAISKLLLNKPKKVGVVLSTKKGQCRKRVFDEIIKLLEENDVNYLPILVDNISPDILFYDVDCYIIVACPRIVLDDYILYKKPIYTPEEFKLFLKNSFKYKFDEIKEDDF