DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

609 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

65.549 kDa

MQSNAENPRKRFTATSPNGNRQNVSVDTSSNVAGPSRPRIANAVPAEILDDPALNQAIKSILPSNYNFEIHKTIHHIRKASASCVALQMPEGLTLWATGIADIVERFTDATTVIMGDVTYGACCVDDYTAMALGCDMLVHYGHSCLVPVDQTAIKTLYVFVEISIDPAHLAATIRANFPNDRHDFRAKILGGSQSAAGKRSEVDESAGRAQIQIGEQASVASGAPPSTLTHLALVGTVQFINAINGLREALRQQQHRLADGQIVSTESPVDRLMLTAGTASSAPVQHITQAAKWKAWSSGEYKVTVPQVKPLSPGEVLGCTSPKLDKDEIDAIVYIGDGRFHLESIMIANPRIPAFRYDPYTKRFVRELYDHAEMRRMRGEAVRLAQDSVGGLDLDPETSIVKKNKAVVVDAEKDRVTASGWGVLLGTLGRQGSLRVLESLSASLSEHVPPIPHVPILLSELSPQKLGLFGEHLAAFIQSSCPRLSIDWGSAFAKPLLSPYEAAVSVKKVKGWQEDVQGLGMSRTPAKQQQDGNGNGSDAVPAEDKHLPLDGDYPMDFYSDTSLGPWTPRHGMAPAKKPVGAKSNLALLRSLRSKRAKASSTPTSAATA

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

529 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

57.461 kDa

MPVPVDDSTAVLEPTEGIERPTKPAVKSRKRFVGSSKAATSRPVVRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQATPDLSTNDLPTRLALVSTIQFVAATQALRADLETAMPPLEKGEIEQEEEGMVAKVKRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYVGDGRFHLESIMIANPTVPAFRYDPYSKKFTREVYDHTEMRGLRGEAVKAARKNLDDQGSGSWAVLLGTLGRQGSLAVLKSIQNSLPADSLPPLLLLLSELSPAKLALLPNSQISTFIQTSCPRLSIDWGYAFSRPLLSPYEASVAVGRVKGWGGLSLDNGKEGGKLEGEGDYPMDFYADNSLGDWTPRHNPPRPRPARVRPQAQGCAQD

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

529 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

57.461 kDa

MPVPVDDSTAVLEPTEGIERPTKPAVKSRKRFVGSSKAATSRPVVRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQATPDLSTNDLPTRLALVSTIQFVAATQALRADLETAMPPLEKGEIEQEEEGMVAKVKRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYVGDGRFHLESIMIANPTVPAFRYDPYSKKFTREVYDHTEMRGLRGEAVKAARKNLDDQGSGSWAVLLGTLGRQGSLAVLKSIQNSLPADSLPPLLLLLSELSPAKLALLPNSQISTFIQTSCPRLSIDWGYAFSRPLLSPYEASVAVGRVKGWGGLSLDNGKEGGKLEGEGDYPMDFYADNSLGDWTPRHNPPRPRPARVRPQAQGCAQD

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

472 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

53.452 kDa

MSDSNNIEDNVVINTITNTDTNDTTPPTTDTNTTPSVTLKRRFVGKKKIAAQQQQQNENIDNVTTTKTTTTTTTTTTPITKDIVTTEKKVKVFGRGLAMAAQQIPDEIMNDKELNLAVKILPSNYNFEIFKTIWRIKQASAKRVALQFPEGLLMYSCIISDIIEKFASVETIIMGDVTYGACCVDDYTARSLGADFMVHYGHSCLIPIDVSEIKMLYVFVDIQFDLQHFIETLKFNFKQTQKLIMVSTIQFSASLQSSREPLSEYFSNIFIPQEKPLSPGEILGCTSPKIKFTSPDGDEENNEIVIYLGDGRFHLESIMISNPHVKSYRYDPYSKVFSLEKYDFQEMYKIRRDAIETASKATKFGIILGTLGRQGSPKILDHLEQLLKSNGKHYTTVLLSEIFPAKLDMFSDIESWIQIACPRLSIDWGYAFTTPLLNPYEAEVCLGGINWQSVYPMDFYSKEGGKWTNYSK

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

465 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

51.299 kDa

MADSVEQSSVTTKRISAKGARKRFVGTKSASGKHSQGVDRVGSAAHRPVNQIPEEILKDTKLQEALPENYNFEIHKTIWRIQQVKAKRVALQFPEGLLLFACTIADILESFTGCETVIMGDVTYGACCVDDYSARALGCDLLVHYGHSCLVPIDATAGIKMLYVFVDIKIDTAHFVESVRFNLGAGSCLALVSTIQFVAALQAASNELSKDYQVEIPQCKPLSPGEILGCTAPMLKDKDAVIYLGDGRFHLEAVMIANPAIQAYRYDPYDKTFSKEYYDIDKMHEARQTAIKQASLASKYGLILGTLGRQGSPKVLQTLEKQLQSLNMDYIIVLLSEVFPDKLKLFKDVDAWVQVACPRLSIDWGTAFPKPLLSPYEASVALQSVAWQQSYPMDFYAYSSLGGWTPNNESNRPTPANRRKKNLHTEVIIDNVSDSKPVIKESECGSGETCCGKCTKETDKHSSTP

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

462 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

50.483 kDa

MEEDRRQTDLGTAADIEEAQLAQASPSPAIENETESAAQTQNGATPLKQPKKRFVGRRAATEAAAKNGSSGATGESGAVATAKPRRAPRLLNQVPKEILENPDLKAAISLLPANYNFEIPKTIHRIQTSGSKRVALQMPEGLLLFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTTIKTLYVFVDISIDATHLLASLEHNFASGKTIAVVGTIQFNATIHGVKSSLERGGFRVLVPQIAPLSKGEILGCTSPRLTEDDKIDLILYLGDGRFHLESIMIHNPTIPAYRYDPYSRKLTRETYGHEEMQSLRRTAIHSARSARKWGLILGALGRQGNPHTLGLIEKELKARGIPIVHLLLSEIFPGKLALMSDIECWVQVACPRLSIDWGYAFSRPLLTPYEALVALGEKKDWGDGVYPMDYYGKDGLGRTRPLQIAS

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

445 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

49.244 kDa

MTEPLLSSAAPEMKMEETSSSSNLRQPKKRFVGRRTADAHAQKDASISSKDVESTSVQRVAPRRNPRTLNQVPPEILDDPEIQAAIELLPKNYSFEIPKTIHRIRTSGAKRVALQFPEGLLIFATTISDILTQFCPGTETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTQIKTLYIFVDISIDTSHLIATLERNFQPGKTIATVGTIQFNATLHGLKPVLERAGFKVVIPQIAPLSKGEILGCTSPQLSPTEIDILLYLGDGRFHLESAMIHNPTIPAYRYDPYSRTLSRETYSHDEMHALRRDAINTAKSAKKWGIILGSLGRQGNPNTMAMIENHLNERGIPFVNLLLSEIFPGKLASMSDVECWVQIACPRLSIDWGYAFPRPLLTPYEALIALGVREHWDSANSGVYPMDFYAKEGLGRTKPQQALQGAA

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

443 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.805 kDa

MRRQVMAALVVSGAAEQGGRDGPGRGRAPRGRVANQIPPEILKNPQLQAAIRVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLIPMDTSAQDFRVLYVFVDIRIDTTHLLDSLRLTFPPATALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNVPAYRYDPYSKVLSREHYDHQRMQAARQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLRALGLSFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYAGSSLGPWTVNHGQDRRPHAPGRPARGKVQEGSARPPSAVACEDCSCRDEKVAPLAP

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

439 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (eef2).

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

49.004 kDa

MEPERNESGTPSVAVTPAAPINAGRAPVRRVANQIPDEIAHNPLLLEAMKVLPENYNFEIPKTIWRIQQASAKRVALQMPEGLLMFACAIADIIERFTSAETVVMGDVTYGACCVDDYTAQALGADFMVHYGHSCLIPIDATHGVRMLYVFVDIKIDTSHFVDTIRFNFQAGASLALVSTVQFVSALQAARQALQTDYNVTVPQCKPLSPGEILGCTSPRLNKSVDAVVYLGDGRFHLESVMISNPDTKAYRYDPYSKVFSREYYDHSTMLRHRGEAISVATNAKTWGLILGTLGRQGSPKIMEHLESRLQALGCRYVRLLLSEIFPNKLKLFAEVEVWVQVACPRLSIDWGTAFSKPLLTPYEASVALKEAEWQLTYPMDFYANESLGPWTVNHESHRPTRATVRRTQKPEQRKLQCTDVGATVEECPCQEKVETKTE

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

439 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.908 kDa

MSCSASGECKSTTATPVAPCDPDTCKKSTSTQPRKRFVGRANGSGPSASTSLVKNTTRRPRIINQIPDEILNDEELNEVIATTLPKNYNFEIHKSIWHIRKNNCKKIALQMPEGLLIYACIISDIIEQFCGPDISTVVMGDVTYGACCVDDFSAIALGCDFLIHYAHSCLVPIDSIKIKVLYVFVTIEIDTDHVVKSFKKNFETGTRMAMVGTIQFNPTIHTLKDRLLNEAGIVCTAPQIMPLSKGEVLGCTSANMSTEDYDMIMYIGDGRFHLESAMIHNPDIPAYRYDPYSRKLTREYFDQVEMVSVRKRAIQTAKNAKTIGLILGTLGRQGNTATLDMLQEKLNSKGYETHIVLLSEIFPAKLALFDGVDAWVQVACPRLSIDWGYAFPKPLLTPYEAMVMMDEDTLEGNDYPMDYYGKEGYGRGKQPRAKKEIAI

Dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

438 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells (By similarity).

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.004 kDa

MAALVVSETAEPGSRVGPGRGRISRGRLANQIPPEVLNNPQLQAAVQVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPGSSLALVSTIQFVSTLQAAAQELKADYHISVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNIPAYRYDPYGKVLSREYYDHQRMQATRQEAIAAARSAKSWGLILGTLGRQGSPKILEHLESQLRNLGLPFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISWQQPYPMDFYSGSSLGPWTVNYGRDRAPRGLCQPASDKVQQGSRGGSPAPACESCNCADQKATSPAP

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

438 amino acids

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

47.978 kDa

MAALVAAEAAESCSRNGPGRGRAPRGRLANQIPAEILNNPQLQAAIQVLPSNYNFEVPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGADFLVHYGHSCLVPMDTSAQDFRVLYVFVDIRIDTAHLLDSIRLTFPPASALALVSTIQFVSTLQAAAQELKAEYRVSVPQCKPLSPGEILGCTSPCLPKEVEAVVYLGDGRFHLESVMIANPNISAYRYDPYSKVLSREHYDHQRMQANRQEAIATARSAKSWGLILGTLGRQGSPKILEHLESRLQALGLPFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGTAFPKPLLTPYEAAVALRDISWQQPYPMDFYASSSLGPWTVNHGRDRLLQVPGRLALGKVQGGPARPSPAAACEACSCRDEEVSPIAL

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

436 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.795 kDa

MAEVKKSIPKRRFVGKKNRKENNLDGSNRDVENAALVTINSKRSAGRVATQIPEDILNDKAINEAIKLLPQNYNFEIHKTIWHIRLRKAKRVALQLPEGLLMFGCILSDIFEQFCQVETIVMGDVTYGACCIDDFTARALDCDFLVHYGHSCLIPVDQTPIKVLYVFVDIKIDLQHVVSSLKHNLPSNSRLALVGTIQFVGSLNSIKDALQIQDEDGKGGFYVVIPQAKPLSPGEALGCTSPYIEKGSVDALIYIGDGRFHLESVMIANPDLPAYRYDPYSHKLSIESYAHEEMKSIRYSAVEKARTAKKFGLIQGTLGRQGSPKVLENLKNTLRKNNKDFVCVLMSEIFPSRLGQFSDIDAWIQVACPRLSIDWGYAFPAPLLTPYEASAAFNVVPWKEVYPMDFYATNSLGNWTPNNPENRPLPNRKKTGPVSS

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

431 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

47.813 kDa

MGDSTEKLQANASLRQPKKRFVGRRTADTQAQSSTSVQDVESTSIQKATPRRTPRTLNQVPPEISQDPDILAAIDLLPKNYSFEIPKTIHRIRTSGAKRIALQFPEGLLLFATTISDILTQFCPGTETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYIFVDISIDTSHLIATLERNFQPGKTIATVGTIQFNATLHGLKPVLERAGFNVVIPQITPLSKGEILGCTSPSLSAQQIDYLLYLGDGRFHLESAMIHNPSIPAYRYDPYSRTLSRESYDHTEMHTLRRDAIAAARTAKKWGIILGSLGRQGNPHTMAMIESHLNERGIPFVNLLLSEIFPGKLAAMSDVECWVQIACPRLSIDWGYAFPRPLLTPYEALIALGVRDDWEKTHEGVYPMDFYAKDGLGRTKPQAVQTV

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

428 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.907 kDa

MDNTTEKKEPTKVPRRRFVGKRKTDGKTITTVKADGNEVVRQTKSRVHVGRSLNHIPDDIMEDEELNEAIKLLPQNYNFEIHKTVWNIRKHGAKRVALQMPEGLLIYSLLISDILEQFCNVETVVMGDVSYGACCIDDFTARALDCDFIVHYAHSCLVPIDITEIKVLYVFVTIAIDETHVIKTLQKNFPKGSRLATFGTIQFNPTVHSIKDTLLNDKEHMLYIVTPQIKPLSRGEVLGCTSERLDKNQFDAMVFIGDGRFHLESSMIHNPEIPAFKYDPYNRKFTRERYDQKQLVQVRGEALQVAQKGKVFGLILGALGRQGNVDTVRNLEEKLIKAGKTVVKIILSEIFPQKLAKFDKIDVFVQVACPRLSIDWGYAFPKPLLTPYEANVLLNHDVMFSEEYYPMDYYETNGYGRGRIPEHALVKN

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

426 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.184 kDa

MSTADEVTKKPRRRFVGVSRGENKVSTKQVSGDEAKELVRSAKSNTGARRAINQIPDEILNDENLQEAIKLLPSNYNFEIHKTVWNIRKHNAKRVALQMPEGLLIYSLVISDILEQFCNCETVVMGDVSYGACCIDDFTARALGCDFIVHYAHSCLVPVDVTSIKILYVFVTIGIDEDHLMKTLQKNFAKGTSLAVFGTIQFNPAIHSIREKLLYSESHMLYITPPQIKPLSKGEVLGCTSQRLPKEQFAAMVYVGDGRFHLESAMIHNPDIPAFRYDPYSRKFTRETYDQHQLVEVRSSAIEKARNSQCFGLILGALGRQGNLATVANLEKKLRAAGKKVVRIILSEIFPQKLAMFDHIDAFVQVACPRLSIDWGYAFNKPLLTPYETNVMLGQDRMFNEKYYPMDYYEVNGYGRGKQPTHDNVI

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

426 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.532 kDa

MSPVEKPVEVEKPKVPKRRFVGKKPQNITIKDGEQPLTKTINPARHIGRVMNQIPDDILNDKELNEAIKLLPSNYNFEIHKTIWNIRKTNCKRVALQMPEGLLIYSLIISDILEQFCQVETIVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITSIKVLYVFVTINIDETHLINTIKLNFERGTQIAIFGTIQFNPTIHSVKAKLENDTEKPMYLIPPQTRPLSKGEVLGCTSARLDKEHIKAMIYIGDGRFHLESSMIHNPEIPAYRYDPYSRKFTREYYDHKQMIDVRKDAISTTKYATKVGLILGALGRQGNPITLDKLEKSLSEKGIQVVKIILSEILPQKLAMFDDVDAFVQVACPRLSIDWGYAFNKPLLTPYEAMVMLEKDTMGDEKVYPMDYYSKDGYGRGSIPDHSHLTT

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

425 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.311 kDa

MSGSTESKKQPRRRFIGRKSGNSNNDKLTTVAENGNEIIHKQKSRIALGRSVNHVPEDILNDKELNEAIKLLPSNYNFEIHKTVWNIRKYNAKRIALQMPEGLLIYSLIISDILEQFCGVETLVMGDVSYGACCIDDFTARALDCDFIVHYAHSCLVPIDVTKIKVLYVFVTINIQEDHIIKTLQKNFPKGSRIATFGTIQFNPAVHSVRDKLLNDEEHMLYIIPPQIKPLSRGEVLGCTSERLDKEQYDAMVFIGDGRFHLESAMIHNPEIPAFKYDPYNRKFTREGYDQKQLVEVRAEAIEVARKGKVFGLILGALGRQGNLNTVKNLEKNLIAAGKTVVKIILSEVFPQKLAMFDQIDVFVQVACPRLSIDWGYAFNKPLLTPYEASVLLKKDVMFSEKYYPMDYYEAKGYGRGETPKHAIE

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

422 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

48.216 kDa

MTMGEVEKKPRRRFVGIKKAAEESDPSGSTTELVKKIKPKTNIRHAINQIPPELLNDEELNAAIKLLPSNYNFEIHKTVWNIRKHKAKRVAIQMPEGLLIYSLVISDILEQFCQCEIVVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITTIKVLYIFVTINIDETHLIKTLQKNFPRGSRIAAFGTIQFNPTIHSMKDKLLQSEEHMLYIIPPQIKPLSKGEVLGCTSERLNKEQIDAMVYVGDGRFHLESAMIHNPEIPAFRYDPYNRRFTRERYDQKQLVEVRASAIDKARSSKKVGLILGALGRQGNLATVENLETKLKASGRTVVKIILSEIFPQKLAMFDDIDAFVQVACPRLSIDWGYAFNKPLLTPYETNVMLENDRMFNEKYYPMDYYHINGYGRGKVPNHDDVTI

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

420 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

47.904 kDa

MEPKPEELEKKKVVRRKFIGKRSSVKGDEASLVKSANKTRHVGRVMNQIPQEILNDKDLNEAIRLLPSNYNFEIHKTVWNIKKNGAKRVALQMPEGLLIYSLIISDILEQFCEVETVVMGDVSYGACCIDDYTARALDCDFIVHYAHSCLVPIDITDIKVLYVFVTINIDEQHLINTIKLNFDKGSQLAVFGTIQFNPTIHSIKSKLENDEEKTMYLIPPQTMPLSKGEVLGCTSARLNKEQIKAMIYIGDGRFHLESSMIHNPEIPAYRYDPYSRKFTKEYYDQKQMIEVREDAVKIASNAKKIGLILGALGRQGNPVTLNNLETKLSAKGIQVVKIILSEIFPQKLSMFNDIDAFIQVACPRLSIDWGYAFNKPLLTPYEAMVMLENDTKWNETYYPMDYYSKEGYGRGKVPDHSNVI

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

409 amino acids

May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

45.015 kDa

MAAPQRSGSAALLPSANGAGRAARRTARQVPEELLNNVELREAVGALPSNYNFEIPKTIWRIRQAGAKKVALQMPEGLLMFACTIADIIERFTDAEAVVMGDVTYGACCVDDYTARALGADFLVHYGHSCLIPIDATRGLKMLYVFVDIKIDTSHFLDTIRFNFAVGSSLALVSTIQFVAAVQAASQELQSQYKVCVPQCKPLSPGEILGCTSPRLARDTDAIVYLGDGRFHLESIMIANPGIPAYRYDPYSKVFSQEHYAHDRMHGARQAAIRSAARARCWGLLLGTLGRQGSPAILQHLESRLRALGRPFVRVLLSEIFPSKLQLFDSVDAWVQIACPRLSIDWGEAFSKPLLTPYEAAVALGDIEWQQPYPMDFYASQSLGPWTANHTARPAQEKPPATPSLKKWH

dph1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

381 amino acids

May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

42.77 kDa

MAASSSELEVITAKKPNVKGPRRVANQIPEEILKDSDLNEAIKALPANYNFEIHKTIWRVRQAKAKRVALQLPEGLQMFACVIADIIERFTEADTLVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTEGIKMLYVFVDIQIDTAHFLDTLRFNFPPGRSLALVSTIQFVAALQAASAALKPDYEVLVPQCRPLSPGEILGCTSPRLDKHVNAVIYLGDGRFHLESIMIANPDTPAYRYDPYSKVFSREYYDHDAMRATRLKAIESACSAQRWGLILGTLGRQGNPKILEHLESQLKSLGRSFTRVLLSEIFPRKLELLADVDAQQWRYSRLDGRMCIPWISIPIRVWGPGLLIIRITNLNGLHAKPHRRLVSR

dph1

Deubiquitination-protection protein dph1

354 amino acids

Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.

36.819 kDa

MTNISLTIKAANDQKYAVTVDSESSVLALKEAIAPVADIEKERQRLIYAGRVLKDEESLKTYKIQDGHSIHLVKTLGQNPAAAATNVSDRTQQVPTNIQAGQGANNPLANLTSARYAGFNIPMPSASMFGPNPENPVPPSTEELANMLSNPMVQSSINEMFSNPQMLDMIINSSPHLRNAPPYVRQMMQSPEFRRAMTDPDTMRQMAQLHQQMGAAGIDPMSLMGGGLGGAGLGGLGGAGLGGFGGANNATAGIAGAAPVDQTAAANTIQNLLNNLGGAGFGAGLGDAGLGAGLGGAASPPAPAQDTRPPEERYAEQLSQLNEMGFVDFERNVQALRRSGGNVQGAIESLLSDL

DPH1

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

347 amino acids

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

Belongs to the DPH1/DPH2 family. DPH1 subfamily.

39.759 kDa

MVVLKQEEVPECLRYLPRNYNFETGKVLRTIRRLGAKRVTLQFPDGLLRYSFVIMDVIEKYTGAECILLNDVVYGGCCIDDESIASDLLVHYGHSCLVPVGEMSTKVLYIFVDIRIDIDHAAEMIRRNFQGKIGVIGTIQFNSSINRLKRVLDEERGGVECTLPQIRPLSSGEVLGCTAPKIEGVSAVISIGDGRFHLEGAMIRNPHLRFYKYCPFSRRMTQESYDHSTMLSDRKSEIRKAFSGRSFGVILGSLGRQGNRSILRSVVDRLKEYDVYLIMLDEISPKKLERYNFIDSFVQISCPRLSIDWGKLFKKPLLTPFEVFYSGGEYLMDYYSREGSGEWKNYR