DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

1343 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

155.678 kDa

MISGHLQTPDSSDHSGDEAKLTKPSGLESKTNELWSSDLEEELESRIMQPATFSSILKQFPSISEETIISKIMSNKNCDKNNWKKKIYCYRYFLQPSKEEPDVGNMKSLVEKLEKLKLKKWSASEIEQLFCNYLEDLTTSAVKVSIPGKTLDEVAAAVNNIHPRPRWTRKEIECLIKNENDFKKLEKDLFVRDLDSIKKKIRRDNLSIQNEIQDSEKKSPQSTDSNNKDSSRDLSRKERDQLKKLLSKPICFSELLAKFPGHSWEYIAREIIQLDSSEDNTIWLKKIYYYCVVYSISVDKEITKYIGGGNRIYEKVRSDWSKIKTLDFFKDWSLQEFERLYCFAFHDLTKSALTKNFPSKNLNDICKVVNISFPKVPYTDREMKYLERHLDTPMQTLENNLPFRSRGSIHKKLEALKALTETTEQKQPPTKTRPKNEEEKNVENAAYMKELIMFDLTLEAIENTFPSEPIEEIIKEIKNSEIFDPLSFTRGEKELMAKLVKKGNLIDDCFDYFPLREEEFIRSKYAEAEYVSGRKMKFNTPEERLAYEAKWTLFNMGKQEYGRGNRRSTKRYCEIDELSKLEQEASVKRSKKKIELTEEELEQRRKRSEHFRLCRLKKLEEKREKYRIEKAKRLEKIAAGLIKPSTSGYELKDIVTSAEYFQSIVGDKQKVQEGQKRKRIQTEYFAPEFIEKPKAVKLKTTKRQAEKNKIKKQLKREAQLKIKKKKTIAPKKGKRRVKTNNGIIEEIKDVYKLSSEPYVESEVEEEDEEEDYISPYDPPDIISDSQVKLNGRHLYISSFYKELPEIPELKFVSLPHMEMSGNDITVAKQIMTTANDDILYDDCLAYEIVAQHIKSYRDLPISFPPVLDPITHELNSANIVRIRFFLYPEHYESFMLASPKSNELDPVHEIAKLFMIQYSLYFSHSDTLKKIITEDYCHKLEHSVEENDFGEFMFVVDKWNQLVMKLSPNLASVQNILGLKEDINEAPRAYLNQQEVSIPTNSDLKIETFYDEIMYESASPLFNPINSNLEIDSESAPIPLGEVEIPNNVIEEINEKMPDNYIPDFFRRLKEKTEVSRYAMQQILLRVYSRVVSTDSRKLRSYKAFTAETYGELLPSFTSEVLEKLNLLPTQKFYDLGSGVGNTTFQAALEFGACSSGGCEIMEHASKLTELQAGLIQKHLAVLGLQKLNLDFALHESFVGNEKVRASCLDCDVLIINNYLFDGQLNDEVGKLLYGLRPGTKIVSLRNFISPRYRATFDTVFDFLSVEKHEMSDIMSVSWTANKVPYYISTVEETIPREYLSREETKETSGKSKSVSPVGEIENVAAAMMTPPTDSSESEIIKN

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

1172 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

135.295 kDa

MENIAHHNTTYNITPICSDSSECSSMEMLPLGCKTHSDKSDARRNLMDTGIYTPDSNSDSSDPRSDSSCVDVSNSLAVSHPISFCNWTDEESSLLTEHIKTDLTSEALTSAFPNKSLALIIRKIHDLQPVLDWTKNEIYLLAGIILNDSNSAIRRHKHKFPCRNVSNLNKKFQHYKNMVRRLNGVDHSKWTKPEIASLISLIDYDLTKTKLQKELPNKNIEEIKDLTNEMRIHSNFSHVESVLFEQTMTENDPIEIVLDQFPLKNKETCKKRLLKLNELSQHRDMAKRRLDEFESLIQNELKQIKDSIDLTRLKYLLVNDLTGKQLRSSFPGISMKYLKLIAKEMGFDEAGEYTLAEMNFLKKALQENAKLKSIIDELPFRSQLSIETKINSVEPNRRRSVFTSQVDELLYMAKWYSSDNFGNLSRRRNSRYASKLDKPKDKASDIMQPSKLHLENEEVTEAKVIPHDKGVENMISDHKLKGKNNEQKKRKSKKPTSMVEVLKEESAYFQSVTGNRCVLKEGQKRKRERLMQIKLETKLKKPKSQNLNETNRIQETKKLMKCDVEPDKVKEQKSFKSENLKEAKLDASDSSIVSDVEISLKKKLNKIENEEKRSPYDPEDISTDTLVPLYGRQLYVNEVYETQPRPPKLSFREDTNIMVQNCSEISLTDTIAADIISQHCKNYRDMPISFPSLTIVDRNTNRMILNPMNKIRIRFLLYPQHSELFILAEPKSNELDPINEIKKLFQLHYSLFFSHSSKLKKIILSEYNKEIDISIEENDFVRFMFVIDKWNRLMVELTPNDVDIGSHDINEEIRAYLSPNEIKIPSDEDIRLDIFYSEIQLSTEENPISDNDPIEPSSPSFDLIKSMKRCFTHDSSNRLTPPISSEEDNKENEPPIESDFRNNNNKGSIPCTPVRLNTRNKMVVNAVKPENYESNFFRHLKEKTSVSRFCVQQILLRIYSRIVSTESRKLRSYKAFTAEVYGELLPSFTSEVLTKVNLQPQHKFYDLGSGVGNTTFQAALEFGVHLSGGCEIMEHASKLTELQTMLLNKHLALLGLKKLPLNFALSQSFVENDIVRQAVIECDVLLVNNYLFDVNLNTAVGKMLYGLKPGTKIISLRNFIRPRYKASSDKTIFDYLKVERHEMSNYLSVSWTANKVPYYISTVQENICEEYV

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

798 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

84.989 kDa

MINFFGGKAPTAAQPASSTSTAVNGARFASVSTSSSASASAAGQPPLKKTKIAPSPVTVVTTVKKKVAPPTSVEPRDPIAALSGYNSKNALPEEKRRRIIEERLAAQRQKSIESSLEAQLRAPTKSLSKSQSASSTSRRSAASFSKPKTKKPRKKVVDSDSDHDEFGDYGKSSRKPSTAPSTPRASKRTSVDPHPTSDSYQKVGRDGVQPNYTVPRDIRASTSPTNTTAIPIDTQSRPSKPISSADIVTANIKNYGPYFNGLGDAPRAVLEYPGTDASEEFLLLVPKDADEYDPLMELLATVRAIVTHYLTPEQRKAFGSLDSLEVSNNAGMILPSATHGASASTSAVCNMVAALTDSNGINGARAKSADLLDGQGSKAERRNHLVGAGTYKDTGSMTPEPHANGISQTAPVSPTSQTSGISASAGGSSVAKTVLVNNALLRLDSPAPTELSVASDHSSTPAASCGTDPDSILRSFTKARNRRDGPLFMRTLARFNSALAALRDTGALAANIADLGSCTGVPEGIWRLIQDQVYARVVGPRVEELGRYQAFSDNVYGELLPRFMSEIAQLTLLGPEKVFVDLGSGVGNLLIQTSLQTGAEAYGCEMMRIPASLASQQVVEAQLRWAAWGLRGGSAIEAWQGDFGDHGGVRDVLKRADVVLVNNYAFLPKTNENLSLLFLDLPDGAKVVSLKPFVPPDFRLTQRTLSSPLAILRVTERLYTSGCVSWADGGGKYYIQEVDRSLVREFLQNAGAATRAKRGKVSEGDDTVAASDLMVGQDVRRKRWKAALQDDDEDDDEF

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

652 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

74.615 kDa

MQEGLKLAERYNASLGSSQTYPIDNHHDKESSTDVATDDIMEKDLHSGKTISSQNSLDGSEASTPVHQLERPTIDVSERNDSRRKFRKKTSLDDLLDQASKFQPQYEYSFPTSFLRKRKAPQSNESDGEEEAKQNRTNKIVKQKKTKKNVKVTSKSKASVPIEEKHTINKQPKKTGTGGMKRGPKPGRKKKSQKNTKNSIKKESTNAINNHKMYEMDSASSRFAEHKNSTNSESANNSFIDWSLPKFSPPYQIFDIDNINSYSNFQGQIYSSASLTKHHNEIGSKTPFSRNRDGSKSPIDDGQGKLIGLRSILYPDYYEEYLMDYKKVNFRYDGMAEIGKIMEYVGRIYLPEKYQKEYKETVVDIYNTAYDNKDLALSISTVEKYNQFVGSIPKAEIVNHLAATKELPRSFLHDFLQIVYTRSIHPYASKLKQYKAFSNYVYGELLPGFLTDVYSKCGLSKNHLFMDLGSGVGNCVIQASLEFGCRESFGCEIMEAASELTEIQMREYSNRCKLFGFKQSKIDYSLRKSFINNEKVESLIPECDVLLVNNFLFDGKLNYEVTKLLQKTKVGCKIISLKNIRASGYTLDTVNIESVLNRLEVKKYRLDNNSVSWTHNGGEYFISTVLDRIDESLLDPQKRDRRNTHRPAKYTR

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

644 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

71.284 kDa

MFSFFGDESKLPASTVMVSRMTVKKQAAARQQSSGPMAGPSKPSNVTPKHSHGSLKGTPRSASEKGTPKQGPSSSSKSTSKVKQEERIRPSTIPRTPASSSSPGRLKRKTPKVQVVESESSSGSESSDDALDSKPKRPKVTRKETGIDMTPLPGEQVVGRRVFCWDKVDMRGEWGRGWAGFVGCDEVVRGNVQGWANGGGGDGSKNLGKYRAFFPQEGFDRDGDFLPSVEVLYPAKGCREKFVLMVPSSDREFNPIGELRNTLRLILEHYIPPSHRHIFGNLAESLDISNPLSSLPSRMTTPLPNSLVTPPPDPASPSPAFAFEISATSTPAPSTERQETIADLIRKSLAPNRRDGPLFVTAIERYNSAMQAIQEDGTLQQWLDEGMNGGKGIKVREWAALVDFVHDQAYSRVVGGYSHELEHHPKHPEEVSKAISGKEDAYGELRHAFMSKIIEQTKLGPDSVFVDLGSGVGNCVLQASLQAGSRSYGFELLPVPAHCARLQVREVQRRWAMWALKGNLDVEVHEGDFRVHKEVGRRLREADVVLVNNEVFPSSLNMDLADMFLDLKEGAKIVSLKPFVPEGFRMNESNCDSFAAILRSTQHDYYRDWVSWKGEWGNYYVAVIDRSRRIKFEESMTGRASRRR

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

644 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

71.286 kDa

MFSFFGDESKLPASTVMVSRMTVKKQAVARQQSSGPMAGPSKPSNVTPKHSHGSLKGTPRSASEKGTPKQGPSSSSKSTSKVKQEERIRLSTIPRTPASSSSPGRLKRKTPKVQVVESESSSGSESSDGALDSKPKRPKVTRKETGIDMTPLPGEEVVGRRVFCWDKVDMRGEWGRGWAGFVGCDEVVRGNVQGWANGGGGDGSKNLGKYRAFFPQEGFDRDGDFLPSVEVLYPAKGCREKFVLMVPSSDREFNPIGELRNTLRLILEHYIPPSHRHIFGTLAESLDISNPLSSLPSRMTTPLPNSLVTPPPDPASPSPAFAFEISATSTPAPSTERQETIADLIRKSLAPNRRDGPLFVTAIERYNSAMQAIQEDGTLQQWLDEGMNGGKGIKVREWAALVDFVHDQAYSRVVGGYSHELEHHPKHPEEVSKAISGKEDAYGELRHAFMSKIIEQTKLGPDSVFVDLGSGVGNCVLQASLQAGSRSYGFELLPVPAHCARLQVREVQRRWAMWALKGNLDVEVHEGDFRVHKEVGRRLREADVVLVNNEVFPSSLNMDLADMFLDLKEGAKIVSLKPFVPEGFRMNESNCDSFAAILRSTQHDYYRDWVSWKGEWGNYYVAVIDRSRRIKFEESMKGRASRRR

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

575 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

63.8 kDa

MANNMNFVRVVANHNSQPSRHIYIKAPVTMAQTVRGADAAGNQNQNAGKGGVETTQLVGGQRPGAARKANRMLLGLLEDSARYDMKSDYSLPDTWLRKRRATAQKTAKAEDKSVDTKKTRAAGKKTKPSEAGPDAKARSGMTSAPSSSSTDAAAPAATGKARNGKARAASSVTRNTVLANASPFASPSEDVIELQHQFFRITDHQDCVNREITSSLLLTPKDVADQQIVRLHFILYPDVSEEYKVTFGHPNNGVFNPIHEIGKCIKYAVEIYFPKTFKKKGSKLLQQLSKAYASMNQSAFVEAVEQYNDLVRAIPQDQVNEHLQQTKKIPRAFIHDILQMAYSRCVLPNVNGLKEYRSFSNFVYGELLPTFLSTVYQQCDLKPGQIFIDLGSGVGNCVVQASLEYGCALSFGCEIMKNASALAKSQLKELEERCALWGVDLKPIEFSLRKSFIDNERVNELLPQCDVLLINNFIFDTKLNQAVEKLIQGLKPGCKIITLKNLRPSGYTINFDDVENILNRLKVEKFTLPEDSVSWTYRGGGEYFISTVQADIDESVFHSYAKGRVRGMRPAKYTK

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

572 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

64.796 kDa

MSTEATSSDASVFSNMHSVDSTRDNTRDNTRDNTPMNEGDTQGKRMTKSTMALIEESMKYDMRSEYFLPMTFLRERRKPARVESDEEDKLAEVKSKRRVSKKDQVKADIHSTKIKKTGRPSNVKAGAKNTSKVTKQRSTKSQVSGKKRARSISDGKVSSIDASRSLKASKKKHSSHADSLFLSNIEENVNPRPSFFNTTLIANPSSFTNKLTSSKMFVDDEEVTSLKGMKYILFPGVEEEYLICSKVQKFGYNPLPEIGQSIESAVLLYFPNTYKTKGQELVRSLNDAFERSDDQSFEKIVLKYNDLISTIPRDLIVKNLSSNPDVPVSFVHFLLHTCYTRAIYPHARKLKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFGCKLSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFVDNERVRELIPQCDVILINNFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRPPGYSINYDDMDNIFNRLHVESFKLPENSVSWTYRSVGDYYISTVLDAIDESIFCPPILGRIRKKESIKYTR

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

510 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

56.217 kDa

MSIFNQKSKFKVKTEVRKVKQAVEPTPESKKRYVGNGSASASTNGTPRASPTPSSLQVKRPRPRPGAGAASPATGPSLSSSTSASPLDLTRKRRAPAGSSSSRSPATASPAPRALSDSEPGSDDDDDDDWRDRLDPSKRRKRAHTEDPDRRLRHPRLWAGQGDEDKPGIVHAVQVASLADKCQPVMKLARDEVGVRLRYPGAKYTERYELVWGKDKIDGALDIMKVVKFVASTYLTDAEAKPFLDHNLGINRRLEKSKNTNDGEGFKAALAEYNNQLLALQTEGAIARNIDAMRGVPRELVEFILDQVYDRTVAPKVDLLAKYENGTDNVYGELLHPFISDIFDRTKLSSDMVFVDLGSGVGNVTLQAALERGCESWGCEMMENACNLAEAQKKEFTARCRMWGIAPGKVHLERGDFRKSERTLAALKRADVVLVNNQAFTSELNDHLVNIFLDLKIGCKIVSLKTFVHDNKIAENDVASSILEVEDLRYHEGYVSWTGAAGSFCISTRK

dot1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

502 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

56.798 kDa

MGFFDHLQKGGAFSLQAQKPQIRKVVQTRPPPPSRSSSHTPVRSLSQTSPPGRVKRPRDSTSRSVSRDPDHRPSKRLSTPLRNRKRPTPEQRFSSDDDASDTDTSFELRKRARTEDSAEPDLARRIRSLKAFSEENVKPLPLVHAADITSKQKAGNFRRAFGGADRPTEILLQYPSASLKERFNLVVPRDNDDFKPIDDIVHVIDIVSENYIPESEADFFNNESTGIKRRLRRALAHSSETEFREAVASYNREIERLRRSGAIAKHLDATHRLNLPLVERILTQIYARTVSPRVESLRRYENGTDNVYGELLPRFISTIFKETRLKSGHVFVDLGSGVGNVVLQAALEIGCESWGCEMMANACDLAELQQTEFRARCRLWGIAPGKTNLVRGDFLQEQSIIDVLKRADVVLINNQAFTPQLNNEIINHFLDMKEGCQIVSLKSFVPAGHKIQSRNLYSPINLLKVKQLNYWSNSVSWTDVGGTYFIATKDSSRLKAFADSME

dot1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

501 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

56.359 kDa

MGGFDYLQKGGTGFTLQVKKPQIRRVVQTRPAAPSPSANKATPRTVPSGPQKKTPETASRSVTGERGFSPSKRRLTPLRNRKRPTPEQRLSSDDDDDGSDTDTSLELRKRARTGESAEPDYGRRLRSLKAFSGDETRSLPIVHASEITSVQKPGKFKPAFENMNQTSEIFLQYPSATPKERYEAVVPRDDDEFKPLDDIVQVIETVTQAYIPEDELDEFNNESTGIKRRLRRALARGSEREFRESVKDYNVAIERLRRSGSIAKKLDATYRLSLPHVERILTQIYSRTVSPRVDSLRQYENGTDNVYGELLPRFISTIFKETGLKSNHVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACDLAELQQAEFKARCRLWGIAPGKTHLVRGDFLKEQSIIDVLKRADVVLINNQAFTPQLNNELINHFLDMKEGCQIVSLKSFVPVGHKIQSRNLNSPINLLTVKQRQYWSNSVSWTDVGGSYFIATKDSSRLKAFSESLA

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

499 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

55.825 kDa

MSFFDHLQKKGVGAIQAQKVQIRKVERKPSKVVSSSSSSSIAKPQRRLDTVSKPVAARRSASSASKPARHPQPRSRPPSRKRNTIEPTLFGSSEESDTDVSLDLRITKRARVSSSVEPDLHRRVRDTDAFSDGEAAFDMIHAADIISSKKSLGFNNAFGIEDGPIIVELQYPGAPQKERYQLVVPRDNDGFKPLDDIVQVLEIVSQNYISEEHLALFEDESNGLLRRLRRALSNTSLTDFLDGVKSYNETIQRLHQDGSISRHLDSKHALALPLVERILTQVYSRTVSPRVDSLRQYENGSDNVYGELLPRLVSKIFAETRLKSDQVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACDLAELQEKEFKTRCRLWGLQPGQTHLKRGDFLEVDSVGKILQKADVVLINNQAFTPELNHKLVNYFLDMKEGCQIVSLKSFVPAGHRIQSRNLNSPINLLSVKQKQYWSDSVSWTNAAGTYFIATKDSSRLKAFLESST

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

493 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

55.587 kDa

MRLFGGKNNKFKVDPPKIRIEKVVVDRPAQKPKPKPNPALSGSASRSSSSHHPSPKPLARQASHSPYPSSCDEKRLERKRKAPSVSRKSPASDRIEFDKDSDGEDDGWMTLDTKRQRKGTEDSGFVDPNRKLRSVRAFEERMDSRKFIHAVDVASLEHKCVPVMGAQKDEVAIRLQYPSLQPREKYELVWGKDKIDAVEASIKVVRHVAETYLTEEEAEPFTNPNGGIIRRLEKASNRNIQDLMGFKAALREYNEKLRALVDDGVIAKNLDKMHELPQHLVAFILDQIYDRTVALKVELLSKYENGTDYVYGELLHPFISKVLVEQTRMTSGQVFVDLGSGVGNVVLQAALEIGCESWGCEMMENACNLAEEQKKEFDARCMLWGVRPGKVHLERGDFRKNAPIHEALKRADVVLVNNKAFTSQLNDDLVRMFLDLKSGCKVVSLKSFVAEKSNNHNINDVGSTILEVEECIYPEGYVSWTNAGGSYFISTRK

DOT1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

492 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

53.624 kDa

MFFSHLGKKNGGPTAKSSDVKRKVTKVKTRKPVVTSVSKSPSPSKTAPPPATAAAAATAAAKPSTPRKSRRKTPNIYQLSKSSLSEVDTEESEREVSSSLSTPGLYELVPRDIVTAGFGSAELATSIHITNASESGNLSMTDIYEPVSTDKSLSDRVKLGALSCDFVEDYSLIKPKVPGEFEPVREILSIMEMTALHFVDKGASEEIKHPVMDDCIMRRFRRSYEGGDLEGMKTSMKEFDEVVKTQRAEGAILANLKQLTAVPQDLAYFLLNQVYSRIVSPESKSLRDYKAFSNNVYGELMPPFMSTVFQKTDLQPSSVFVDLGSGVGNCTLQAALEVGCESWGCEVMTNASSLAEKQKIELYSRAKMFGIKTGDIHLVASSFVHNDEVHSAISRADVLLVNNYAFDGTLNAHLLDMFLDLKEGCKIVSLKSFVPVGHVISEHNIESPVNILKVQKLDFYSGSVSWTAAGGTYYISTVDRSAIKAFLSKGGY

dot1

Histone-lysine N-methyltransferase, H3 lysine-79 specific

335 amino acids

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.

38.178 kDa

MVLARFANESTSYNRYNLVVPRDKDDFRPIDDIFQVIETVSQNYIPEDEADYFDNESTGIKRRLRRALAHASEAEFRNVVTDYNEAIERLRRDGSIAQKLDSTHRLNLPLVERILTQIYSRTVSPRVESLRQYENGTDNVYGELLPRFISTIFKETGLKSGQVFVDLGSGVGNVVLQAALEIGCESWGCEMMQNACELAELQQTEFRARCRLWGIAPGKTHLVRGDFLKEQSIIDVLKRADVILINNQAFTPQLNNELINHFLDMKEGCQIVSLKSFVPAAHKIQSRNLNSPINLLKVKQREYWSNSVSWTDVGGTYFIATKDSSRLRAFAESMG

DOT1

Glycine-rich protein DOT1

255 amino acids

Involved in leaf vasculature patterning.

19.993 kDa

MANHKNLFFLCFLIGLGLCSARRALLSSSESEAEVAAYGVNSGLSAGLGVGIGGGPGGGSGYGGGSGEGGGAGGHGEGHIGGGGGGGHGGGAGGGGGGGPGGGYGGGSGEGGGAGYGGGEAGGHGGGGGGGAGGGGGGGGGAHGGGYGGGQGAGAGGGYGGGGAGGHGGGGGGGNGGGGGGGSGEGGAHGGGYGAGGGAGEGYGGGAGAGGHGGGGGGGGGSGGGGGGGGGYAAASGYGHGGGAGGGEGSGGYVP