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DNAJC3

Gene
DNAJC3
Protein
DnaJ homolog subfamily C member 3
Organism
Bos taurus
Length
504 amino acids
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A (PubMed:7511204). May inhibit EIF2AK3/PERK activity (By similarity).
Mass
57.704 kDa
Sequence
MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIELKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLVKSDEMQRLRSQALDAFESSDFTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKASSKLKNDNTEAFYKISTLYYELGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIKEGRYTDAISKYESVMKTEPGVHEYTIRSKERICHCFSKDEKPVEAIRVCSEVLQVEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQRRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFSPFSSGGPFRFKFHFN

Gene
DNAJC3
Protein
DnaJ homolog subfamily C member 3
Organism
Homo sapiens
Length
504 amino acids
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Mass
57.58 kDa
Sequence
MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN

Gene
Dnajc3
Protein
DnaJ homolog subfamily C member 3
Organism
Mus musculus
Length
504 amino acids
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity).
Mass
57.464 kDa
Sequence
MVAPGSVGSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIALKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEQEEKEAESQLVKADEMQRLRSQALDAFDGADYTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKSDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSVAEYTVRSKERICHCFSKDEKPVEAIRICSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYEAAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN

Gene
Dnajc3
Protein
DnaJ homolog subfamily C member 3
Organism
Rattus norvegicus
Length
504 amino acids
Function
Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity).
Mass
57.561 kDa
Sequence
MVAPGSVRSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTRVIELKMDFTAARLQRGHLLLKQGRLAEAEDDFKKVLKSNPSENEEKEAQSQLVKADEMQRLRAQALDAFDSADYTAAITFLDEILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISILYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIGSAEELIRDGRYTDATSKYESVMKAEPSVAEYTVRSKERICHCFSKDEKPVEAIKICSEVLQLEPDNVNALKDRAEAYLIEEMYDEAIQDYEAAQEQNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQSEEEKKKAEKKFIDIAAAKEVLSDPEMRRKFDDGEDPLDAETQQGGGSNPFHRSWDSWQGFNPFSSGGPFRFKFHFN

Gene
DNAJC3
Protein
DnaJ homolog subfamily C member 3
Organism
Gallus gallus
Length
503 amino acids
Function
May be involved in the unfolded protein response (UPR) during ER stress.
Mass
57.327 kDa
Sequence
MVSAAASAGRLGSALPFLLVLLDLQYQGAECGINAEVEKQLEMGKKLLAAGQLADALSHFHAAIEGDSDNYIAYYRRATVYLAMGKSKAAIRDLSKVVELKQDFTSRLQRGHLLLKQGKFDEAEDDFKNVLKSNPSNNEEKEAQTQLTKSDELQRLYSQALSAYRQEDYEAAIPLLDEILAVCVWDAELRELRAECYIKEGEPSKAISDLKAAAKLKSDNTEAFYKISRIYYQLGDHELSLSEVRECLKLDQDHKQCFSLYKQVKKLNKQIESAEEFIREGRYEDAISKYDSVMKTEPDVPVYATRAKERICHCLSKNQQATEAITVCTQVLQLEPTNVNALKDRAEAYLLEDLYEEAIKDYETAQANSENDQQIREGLERAQRMLKQSQKRDYYKILGVKRNARKQEIIKAYRKLASQWHPDNFQSEEEKKKAEKKFIDIAAAKEVLTDPEMRRKFDAGEDPLDAESQQGGGNPFHRNWNTWQGFNPFGSGGGPFTFKFHFS

Gene
dnajc3
Protein
DnaJ homolog subfamily C member 3 homolog
Organism
Dictyostelium discoideum
Length
502 amino acids
Function
May be involved in the unfolded protein response (UPR) during ER stress.
Mass
57.387 kDa
Sequence
MIVNKKYFLLICIIILISINCLVLAKDEIENFLKEGDDLVSKGKYDLANENYSNAIDLIGSDTQHPQYVSLLFKRAGIYHQKGKNILALSDLNRAIEANPDNIHARLKRAKIQSSLGRFEEAMDEYKRVLKIRPDNSQAKQQIEKLKKVEQQLEKVRDMVKVEKNYKDSIAILLDIQSVVSDLKEVRLMLCECFFQQGDHRKVLDETMTILKSEPSSVAALYWRGKTFFSMGEKEIAMKFLKEGLKFDPDNTNCRAMIKTINKFEKSTANAQELFNQQKYQDALGQIEDALEIEPNSPTHSTPLYLLKCKCLLKVKKGKESIEACNRALELDELNADALYNRAEAYMYEEDYQKALNDYNKAREHKPNDPQIHDGIRRAQKAQQMAKRKDYYKILGIQKSATPEEIKKAFKKLAIKNHPDKSTETDKEKAQQIYMDINEAYEALKDEEKRKRYDMGEDINDPHGGQGGQGGGFGGFGGFHGFQGFQGFQQGGGGGGFQFHFR