Protein
Doublesex- and mab-3-related transcription factor 2
Function
Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning.
Similarity
Belongs to the DMRT family.
Sequence
MTEGQAVPGVGDWEIDVESLDLEEDSCGTPLRATPPQEPSPAAADGEEDEDEEEEDEDVEDEGDGEEPGVSSEVPGRPEQPGGLAPRPPPAAQALPAAAAAPERGATAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFDRKAVYQRQVRAPSLLAKSILEGYRPMTAETYLGGTLPLPPPVSDRMRKRRAFADKELENIMLEREYKEREMLETSQAAALFLPNRMVPGPEYSSYKGTYSPTAGELPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQYPLSSRFLVWPKCGPISDTLLYQQYLLNATTSVQALKPGTGWDLKGTRVQDGLSAEQDMMPPKLEGSLVLPHLPEVPASRTDLQVHQVVPERSAFSPPGRNFSPIVDMDCLAAQGHVLTKLSKENTRPSLPLKTNPFHSVFQQTLSDKSGPELNAPFVKEAFEETPKKHRECLVKESQKYTFTIDRCAKDLFVAKQVGTKLSANEPLSFSVESILKRPSSAVTHVSQ