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DMAP1

Gene
Dmap1
Protein
DNA methyltransferase 1-associated protein 1
Organism
Mus musculus
Length
468 amino acids
Function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity).
Mass
53.13 kDa
Sequence
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Gene
DMAP1
Protein
DNA methyltransferase 1-associated protein 1
Organism
Homo sapiens
Length
467 amino acids
Function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Mass
52.993 kDa
Sequence
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP

Gene
DMAP1
Protein
DNA methyltransferase 1-associated protein 1
Organism
Drosophila melanogaster
Length
433 amino acids
Function
Involved in transcription repression and activation (By similarity). Required for larvae and pupal development, and for normal innate immune responses (PubMed:24947515). Involved in modulating the activation of the immune deficiency pathway (Imd), acting either downstream of, or at the level of, the NF-kappa-B factor Rel (PubMed:24947515). Possibly functions with akirin to regulate Rel, and its interaction with the Brahma complex protein Bap55 suggests that it may regulate the IMD pathway at the level of chromatin remodeling (PubMed:24947515).
Mass
50.248 kDa
Sequence
MSADVRDILDMERANTPEVTRDSFLATKKRNFERTKTASRRPEGMHREVFALLYTDKKDAPPLLPTDTALGIGAGYKETKARLGMKKVRKWEWAPFSNPARNDSAVFHHWKRVTDNSTDYPFAKFNKQLEVPSYTMTEYNAHLRNNINNWSKVQTDHLFDLARRFDLRFIVMADRWNRQQHGTKTVEELKERYYEVVALLAKAKNQTSEKKVFVYDVEHERRRKEQLEKLFKRTTQQVEEENMLINEMKKIEARKKERERKTQDLQKLISQADQQNEHASNTPSTRKYEKKLHKKKVHQQPRPSRVDSVVNAIEIGSSGIKFADLRGSGVSLRSQRMKLPANIGQRKVKALEQAIQEFKVDPAPPPTEDICTSFNELRSDMVLLCELRTALSTCVYEMESLKHQYEAACPGKTLNIPPSLVPIKTEALDNSTN