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DIABLO

Gene
diablo
Protein
Diablo homolog, mitochondrial
Organism
Xenopus laevis
Length
244 amino acids
Function
Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). Promotes apoptosis.
Mass
26.969 kDa
Sequence
MASLPRRLLWSVSYIVRESFPIVSKRNCVSLLQGSWRKVLSVGVGTSLCAIPVGQRSEPTLSSESLIKRAASLVADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYSSLLDKINSNEESAIWQVIIGARVQINQLKEQYMKYESSWQRAVSLSEMAAEAAYQSGADQASMTVRNHIQIVQTQVQGARDQAHMAEVQLAASQTEEIKRTITEDKGNPPSGGSPRNSLSEEEDIPEAYLRED

Gene
diablo
Protein
Diablo homolog, mitochondrial
Organism
Xenopus tropicalis
Length
244 amino acids
Function
Promotes apoptosis. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity).
Mass
27.155 kDa
Sequence
MASLPRRLIWSFSYILRESFPIVSRRNCVSLLRASWRKVLSVGVGTSVCAIPVGQRSEPTLSSESLIKRAVSLVADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYTSLLDKMNSNEESAIWQVIIGARVQMKQLKEQYLKYESSWQRAVSLSEMAAEAAYQSGADQASVTVRNHIQIVQTQVQQARNQAHIAEVQLAASQTDEIKRTITEDKGNPPSGGSPRSSLSEEEEIPEAYLRED

Gene
DIABLO
Protein
Diablo homolog, mitochondrial
Organism
Homo sapiens
Length
239 amino acids
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Mass
27.131 kDa
Sequence
MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED

Gene
DIABLO
Protein
Diablo homolog, mitochondrial
Organism
Pongo abelii
Length
239 amino acids
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).
Mass
27.146 kDa
Sequence
MAVLKSWLSRSVTLLFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTVGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQAPITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED

Gene
Diablo
Protein
Diablo homolog, mitochondrial
Organism
Mus musculus
Length
237 amino acids
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).
Mass
26.82 kDa
Sequence
MAALRSWVTRSVCSLFRYRQRFPVLANSKKRCFSELIKPWHKTVLTGFGMTLCAVPIAQKSEPQSLSNEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQLSQKAETKLAEAQTKELHQKAQEVSDEGADQEEEAYLRED