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DIA2

Gene
DIA2
Protein
Protein DIA2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
732 amino acids
Function
F-box protein component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). The SCF(DIA2) complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. The SCF(DIA2) complex binds to DNA replication origins. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein. Required for invasive growth and growth under alkaline conditions.
Similarity
Belongs to the DIA2 family.
Mass
85.07 kDa
Sequence
MSSPGNSGVAIDSTVLKAIELGTRLFKSGEYLQAKRIFTNALRVCDSYSQEQIMRIRNAYQLDTARPDNKRLYHPRYIKILDNICACYEKLNDLKSCLDVSQRLLKLEPGNIKCYIRCTRTLIKLKDWKRAYKTCSRGLQLCNNDSNHLRQQKQFIKNNMVQKQDGKRSYIDPLEETKIAKKKKNNNVLESLPKKKIKGSTKKTDLVGNLPIEILPIIFQRFTTKELVTLSLVCNKWRDKILYHLDCFQEFNLAPINFKNFVKFMDFLQQNFTRTYRKYILSQVKVSSRITSEELRITQLLFSKMPKCINIERLILSMPTLTTTQIFKLMVRGGTDFFTRLLELSLMITYRPDKQHELEILQTCPLLKKIELIFVNSLVPIFDGNNSVGRDGSFNVMARHTNMQISTADNDEQGIVEEKVIYSELEKITLICDKKKIKNFPLCRALLRGQFPLLQKLTITGVTFPMNNQDIMNFQWLLNFPDLKELWIEDNDNCELSKFLQLLKFSNVWKNLEKLTFRENKLYPIVNLDEDQPVTNDDEVPSMLFYKENLQNLEKLDLMGTSISGSALTRLCEQEYLDGRKLRSLNIGNCPNIQFPNNHAHTARMILDVNAVLKRLSKLEEINLSHLSSLNDSTMKSFIINVPFLENLKRLDISHNFEITGISIYEFLKKFQMDHDNEAGGQPLAYLNIDGCSQVSHITVNMIRAQNLVTQVDCVYERDVWRKFGINSYSYS

Gene
DIA2
Protein
Protein DIA2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
685 amino acids
Function
F-box protein component of a SCF ubiquitin ligase complex involved in ubiquitin-dependent protein degradation. The SCF-DIA2 complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein (By similarity).
Similarity
Belongs to the DIA2 family.
Mass
79.1 kDa
Sequence
MSEDIIDRSLELGIQCFQGEDYKGAAELFSKSLQLARSYTDRSLEGIREKVGLPKRCLHDPSRVYHPRYLVLLDNRAATWEKLNKLDRALADAAYMITVDAYNLKGYIRRGKVLQKLGRYEEALQVYENGLKQAGEAEKTHAIHAPQKFLDIVYRQRSTIKELLQSRARSSRSLTQQTVAKEPKLKRPATIDSLMPGKKRSSSKAKIDYIATLPVEIIERIMANMDTRSIIRCYSVCKLWKYRLERLPHLYQEFRLSCCYKNMLGYVNFVGALASRTAEYSCRSIQCVSGNVQEEEKSIILLLSRLMIGTRQLALMAKKCKAERIIQHICENKKLRNGVQRLSITAPVHFGHKLNLHELYTRTTSMTHLELVLNFHTPSEHVGGHLFPWQDHAVAETNLESFTLMARNYSVHHVNVIEQFEYSSVLFKRLKKLCITGIDFRLGDRNNLKWISDMPNLQELWLERNTGIEFHELITQIVQVGAPKTLRHLTFREPPNRHFDRMDQSQLGLGEEALREVFQSLESLDLMNTRFDPQLLLLLLQPACENRIARLNIGNCPRLSFARDLEILTLIFQQLPALTDLLLPNVMEYTRQGMEVLRKNIKGMKLKRLDLSFIPSLKGYELLDLLKELKGINPLGLETLTINGCTAVAPQTVDYITRNGYAQKVMCAYERTQWEHLGINSFWYR

Gene
dia2
Protein
Differentiation-associated protein 2
Organism
Dictyostelium discoideum
Length
151 amino acids
Function
Has an essential role in the initiation of differentiation. Also required for cAMP signaling.
Mass
16.945 kDa
Sequence
MKQIIRLITTLLLLSLIGITCAAVAKLHETDKKFKGVELPEKFLDDFNLEVGKLQYANLFRSKKDDITHSAGEIRIDQQGSFSRGEKKKKFKVYNLQAQTNGKSSKTVAHVEVFDTIDAKTKAEQNEVLALAKEAFTKSKDSGKLYQVIPN