DHS1

Deoxyhypusine synthase

379 amino acids

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. Also able to produce homospermidine from putrescine.

Belongs to the deoxyhypusine synthase family.

42.083 kDa

MGEALNVMESVRSIVFKESENLEGSATKIEGYDFNKGVNYAELFKSMASTGFQAANLGDAIQIVNQMLDWRLSHEQPMEDCSEEERDVAYRESVTCKIFLGFTSNLVSSGVRDTIRYLVQHRMVDVVVTTAGGIEEDLIKCLAPTYKGDFSLPGAVLRSKGLNRIGNLLVPNDNYCKFENWIIPIFDQMYEEQIKEKVLWTPSKVIARLAKEINDETSYLYWAYKNRIPVFCPGLTDGSLGDMLYFHSFKKGDPDNPDLNPGLIIDIVGDIRAMNSEAVHAGSRKTGMIILGGGLPKHHVCNANMMRNGADFAVYINTAQEFDGSDSGARPDEAVSWGKIRGGAKTVKVHCDATIAFPILVAETFAAKRKELSHIRCQV

DHS1

Deoxyhypusine synthase

371 amino acids

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. Also able to produce homospermidine from putrescine.

Belongs to the deoxyhypusine synthase family.

41.387 kDa

MEESMKQASVMENLRSVVFKESESLEGTCAKIRGYDFNNGIDYSQILKSMVSTGFQASNLGDAIETVNQMLDWRLSHEQVTEDCSQEEKNPTYRESIKCKIFLGFTSNLISSGVRDIIRYLVQHHMVDVIVTTTGGIEEDLIKCLADTFKGEFSLPGAELRSKGLNRIGNLLVPNDNYCKFEDWIIPIFDQMLEEQKAKNVLWTPSKLIMRLGKEINNESSYLYWAYKNDIPVFCPGLTDGSLGDMLYFHTFRNPGLIVDVVQDIRAINSEAVHANPRKTGMIILGGGLPKHHICNANMMRNGADYAVFINTAQEFDGSDSGARPDEAVSWGKIRGSAKSVKVHCDATIAFPLLVAETFAAKREQSAEPSS