DFRA

Gene

DFRA

Protein

Dihydroflavonol 4-reductase

Organism

Antirrhinum majus

Length

446 amino acids

Function

Bifunctional enzyme involved in flavonoid metabolism.

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Mass

49.633 kDa

Sequence

MSPTSLNTSSETAPPSSTTVCVTGAAGFIGSWLVMRLLERGYTVRATVRDPGNMKKVKHLIELPKADTNLTLWKADMTVEGSFDEAIQGCEGVFHLATSMEFDSVDPENEVIKPTIDGMLNIIKSCVQAKTVKKFIFTTSGGTVNVEEHQKPVYDETDSSDMDFINSKKMTGWMYFVSKILAEKAGMEAAKENNIDFISIIPPLVVGPFIMPTFPPSLITALSPITGNEAHYSIIKQCQYVHLDDLCEGHIFLFEYPKAEGRYICSSHDATIYDIAKLITENWPEYHIPDEFEGIDKDIPVVSFSSKKMIGMGFIFKYTLEDMVRGAIDTCREKGMLPYSTKNNKGDEKEPILNSLENNYNIQDKELFPISEEKHINGQENALLSNTQDKELLPTSEEKRVNGLESALLSKIQDKEVLPTSGVKHAKGQENALLPDIANDHTDGRI

Protein

Dihydroflavonol 4-reductase: DFRA

Gene

DFRA

Protein

Dihydroflavonol 4-reductase

Organism

Arabidopsis thaliana

Length

382 amino acids

Function

Bifunctional enzyme involved in flavonoid metabolism.

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Mass

42.775 kDa

Sequence

MVSQKETVCVTGASGFIGSWLVMRLLERGYFVRATVRDPGNLKKVQHLLDLPNAKTLLTLWKADLSEEGSYDDAINGCDGVFHVATPMDFESKDPENEVIKPTVNGMLGIMKACVKAKTVRRFVFTSSAGTVNVEEHQKNVYDENDWSDLEFIMSKKMTGWMYFVSKTLAEKAAWDFAEEKGLDFISIIPTLVVGPFITTSMPPSLITALSPITRNEAHYSIIRQGQYVHLDDLCNAHIFLYEQAAAKGRYICSSHDATILTISKFLRPKYPEYNVPSTFEGVDENLKSIEFSSKKLTDMGFNFKYSLEEMFIESIETCRQKGFLPVSLSYQSISEIKTKNENIDVKTGDGLTDGMKPCNKTETGITGERTDAPMLAQQMCA

Protein

Dihydroflavonol 4-reductase: DFRA

Gene

DFRA

Protein

Dihydroflavonol 4-reductase

Organism

Petunia hybrida

Length

380 amino acids

Function

Bifunctional enzyme involved in flavonoid metabolism.

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Mass

42.435 kDa

Sequence

MASEAVHAPSPPVAVPTVCVTGAAGFIGSWLVMRLLERGYNVHATVRDPENKKKVKHLLELPKADTNLTLWKADLTVEGSFDEAIQGCQGVFHVATPMDFESKDPENEVIKPTVRGMLSIIESCAKANTVKRLVFTSSAGTLDVQEQQKLFYDQTSWSDLDFIYAKKMTGWMYFASKILAEKAAMEEAKKKNIDFISIIPPLVVGPFITPTFPPSLITALSLITGNEAHYCIIKQGQYVHLDDLCEAHIFLYEHPKADGRFICSSHHAIIYDVAKMVREKWPEYYVPTEFKGIDKDLPVVSFSSKKLTDMGFQFKYTLEDMYKGAIDTCRQKQLLPFSTRSAEDNGHNREAIAISAQNYASGKENAPVANHTEMLSNVEV

Protein

Dihydroflavonol 4-reductase: DFRA

Gene

dfrA

Protein

Putative dihydroflavonol 4-reductase

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Length

343 amino acids

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Mass

37.864 kDa

Sequence

MEVNHWIAMADCFFVTGGTGFVGANLVRHLLEQGYQVRALVRASSRPDNLQNLPIDWVVGDLNDGDLHQQMQGCQGLFHVAAHYSLWQKDREALYRSNVLGTRNILACAQKAGIERTVYTSSVAAIGVKGDGQRADESYQSPVEKLIGAYKQSKYWAEQEALTAAQQGQDIVIVNPSTPIGPWDIKPTPTGEIILRFLRRQMPAYVNTGLNLIDVRDVAAGHLLAWQRGKTALTRGDRYILGHENISLQGILAHLSTITGLPAPKNTVPLWLPLTFAWVEEKVLAPLGRSPSVPMDGVKMSAQEMYYDASKAVQELGLPQSSIKQALADAVHWFQNHGYVKTQ

Protein

Putative dihydroflavonol 4-reductase: dfrA

Gene

dfrA

Protein

Dihydrofolate reductase

Organism

Bacillus subtilis (strain 168)

Length

168 amino acids

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

Similarity

Belongs to the dihydrofolate reductase family.

Mass

19.176 kDa

Sequence

MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKKNSSKAGGF

Protein

Dihydrofolate reductase: dfrA

Gene

dfrA

Protein

Dihydrofolate reductase type 1 from Tn4003

Organism

Staphylococcus aureus

Length

161 amino acids

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Similarity

Belongs to the dihydrofolate reductase family.

Mass

18.461 kDa

Sequence

MTLSIIVAHDKQRVIGYQNQLPWHLPNDLKHIKQLTTGNTLVMARKTFNSIGKPLPNRRNVVLTNQASFHHEGVDVINSLDEIKELSGHVFIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRRKGK

Protein

Dihydrofolate reductase type 1 from Tn4003: dfrA

Gene

dfrA

Protein

Protein DfrA

Organism

Myxococcus xanthus

Length

131 amino acids

Similarity

Belongs to the RutC family.

Mass

14.064 kDa

Sequence

MRRMARKAIHSDQAPKAIGPYSQAVQVDAGKMTFLSGQIPLDPATMEMVQGDVVAQAERVMENLKAVLAASGLDFSHVVRCTIFLTDLGDFARVNEVYGRYFTGAPPARATVQVSALPRGSKVEIDAIAVS

Protein

Protein DfrA: dfrA