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DEP1

Gene
dep1
Protein
Transcriptional regulatory protein dep1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
491 amino acids
Function
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).
Mass
55.628 kDa
Sequence
MTENLQSESIPHEILPKEPFDLPMNNLKSSPKNKDSEKRINNSIAESEQVVDSALSNPETNANEDIIAPQLPSQNSEIIEKNSPVNKLNSSTSLTTHQLASLPKLEVTDHDNVSEAETVVLNEDEEKETSLVGSVSVTEDLGDSSAIGRTILVNNSVEPQMENTANITIVSPSLKESDFESEEKATNDNNGLIETNHNSKLEESSEHEEEEDEESNIERTEDSDHQIPQRGGTLEAPRKGGPRSGVGSRKRKRATVSRKWSTNSESKIKRVALETSQEESDREIADRRSASEQAHEADDEKAIKRKEAFDALLNIETEFTFLRNRLYGKKLLKLNEHEEMIQNETHERFNACIDLITERRDDRVRLATENLMKQLGNIKNVMDYVTKQRKYQLLFDKRRIRQALLTKIATKCFQLLNKQKSVHDPTYITQKTMSYRQSALLQKQRIEYEAAVLCELNSFAGFPTAPIIETASFDDIRNDLLEMGCLSENQD

Gene
DEP1
Protein
Transcriptional regulatory protein DEP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
405 amino acids
Function
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Mass
46.978 kDa
Sequence
MSQQTPQESEQTTAKEQDLDQESVLSNIDFNTDLNHNLNLSEYCISSDAGTEKMDSDEEKSLANLPELKYAPKLSSLVKQETLTESLKRPHEDEKEAIDEAKKMKVPGENEDESKEEEKSQELEEAIDSKEKSTDARDEQGDEGDNEEENNEEDNENENEHTAPPALVMPSPIEMEEQRMTALKEITDIEYKFAQLRQKLYDNQLVRLQTELQMCLEGSHPELQVYYSKIAAIRDYKLHRAYQRQKYELSCINTETIATRTFIHQDFHKKVTDLRARLLNRTTQTWYDINKERRDMDIVIPDVNYHVPIKLDNKTLSCITGYASAAQLCYPGEPVAEDLACESIEYRYRANPVDKLEVIVDRMRLNNEISDLEGLRKYFHSFPGAPELNPLRDSEINDDFHQWAQ

Gene
DEP1
Protein
Depudecin biosynthesis cluster protein 1
Organism
Alternaria brassicicola
Length
369 amino acids
Function
Part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099). The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099). The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
Similarity
Belongs to the paxA family.
Mass
40.287 kDa
Sequence
MPQTSTTQFFYLSALGIWGLWVYAFFNGMFDRLDTITRTLHFPDGRPLRSKYTNIGPLDAQLTLLSAFYDVLSNTLTSGPRLLFFDVNYVVACANLWVLIESRRRGVRSWFLKYPAWAMVLCNANGAAIVLPLYLYLVCCSKARLRDASVPKHEATALLVSTVVILLQPLLIFVPAWAGRGGSHLHHGCIALFQVAPIGVSVFHLGLASILPREASDSSPSSRKDSKKCIVASLVLAGTVAAAVHSYTVVGALITRDGQASLTRLFVPAHGFSDPIEVPLQPSGLPAEYMALVENLHLFSQWDWIVVALTSVLYSHLLLSLRDGAVRAKANHWVSPVEAQELVYLTVATIILGPGGAASFALAIRESRI

Gene
DEP1
Protein
Depudecin biosynthesis cluster protein 1
Organism
Fusarium langsethiae
Length
365 amino acids
Function
Part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114). The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099). The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
Similarity
Belongs to the paxA family.
Mass
40.524 kDa
Sequence
MFQTSRSQLLYLSALGVWGLWGYAYFNGMFTRLDTITRTLHFPDNRPLRDSYTGLGPLDKQLTLLSVFYDVLTNSLSSGPRLLFFDINYAVACTNLWTLIESRRRGVRSWFLKYPAWAMVLCNANGAAIVLPIYLYCVCRSKARLRDPVVPLHEAVALPIITVVMLLQPLLIFAPAWFGYSGSETHHALIALFQVAPVIVLGLYVGITSLLSYHFPATSLSSKEYKKWISASLILAGSVASAVHIYTLTGALFTRDSDVSLTRLFVPTGGFTDPIKTLVSNENLLAEYAALLENLHLFSQWDWIVVCLTSVVYAQLLLSRREGLKVNKPAVPYEAQEMIYLTIATVVLGPGGAGSFALAIREARI