Dennd1a

DENN domain-containing protein 1A

1016 amino acids

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556).

111.538 kDa

MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQESQWNELLETLHRLPIPDPGVSVHLSVHSYFTVPDSRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFSEEAFVSHYRSGAMKQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCVSSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHVVRRPKSNITVEGRRTSVSSPEQPQPYRTLKESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLEDVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPYTKLWSLGQDDMAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLLRKTKQDVSPSPAPALAPASTSVEQLRRQWETFE

dennd1a

DENN domain-containing protein 1A

1010 amino acids

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P.

112.377 kDa

MGSRLKQNPDTTFEVYIEVNRPGSTDEDPELQRIFPEDFSDQEVLQTVTKFCFPFSLDSLTSSHVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEAFYKLLNILAEYSSKNQDSQRNELLKTLHGHPIPEPGTPMHLSVHSHFTVPDSQELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILICCSKLSTLTACIHGSSAMLFPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHSSLMEKVKGMSLDDVVFLNVDTNTLETPFDDLQNLPNEVVSALKNRIRKMSTTTGDGVARAFLKAQASLFGSYRNALKIEPEEPITFCEETFVSHRSSGLRPFLQNAIQLQLFKQFIDGRLDLLNSGNGFSDVFEEEINMGEYAGSDKLYHQWLSTVKKGSGAFINTMKTRANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDMAENGFSTATEEPLPQISPSSIEKKRGEERRPITVHFGQVRPPRPHVPRRPKSNAVVESRTTAGSSPDQPQQYRTLKESDADGDEAISPEKDSSEATVKEPQSTEVKHVSLLEDIFSNLQTEPPLLSQAKSLEDLRTPKEDHENQFTFDYQRMDLTAQERTRTIPAMKHGHPYNKLWSMGHDDMAIPNKYLQISPERHLTLPSNSTVTPHKDSALTNIEKEVTIASSQGNITIPRPHGRKTPELGIVPPPPAPRGIKLQTAMTDANKQQTGDSSNYHGQITEGSLRELSADNGEKETAGSSTSEILKPVKVSTEVGMNDDDLLSLLDPLKAGRYQTASQPPMGTLPHSFETPCCSSTPLLTSLQSDFVSPAFSHQLGFAPQPAFLHSPLNPFAQALAAEKTASVMGPPMGVFKAPVATALGSHSFLPTPGIYHSPRPLTSALQGSNLFGQISSGTPLNPVIRQSHSLSETQSNMPLMTSIPAGHRTLPMVQSRSKHQDGKPREYPPIPPRPAKLLEPALLPTKSDQPIDPFEDLLNKTKQTVTPASGKVEHLRKQWETFE

DENND1A

DENN domain-containing protein 1A

1009 amino acids

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).

110.577 kDa

MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLRKQWETFE