Protein
Lon protease homolog 2, peroxisomal
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
Similarity
Belongs to the peptidase S16 family.
Sequence
MARYKPNQQNHTDPKQQVVLPTYKLDSNLVLLPGIIYNVTFSRFKAATLLSRFKSQVSNVSLITNLLNEYDFDSKQEEKDDVESKYMPPPISSDAVTGIKQFYQYEQQFKGKNDDSSKVEAEPQSEFDWLVLAINPNLEKIKEPQTSSDDEYENIVTIARVIGMVDDTSNIKLTLQALTRGIKHNKVKPTQTNEVLIDIDWNSNIDDVASKYDVLNSKVLKLFRSIDGFIVDYRQALTVAASLAKKGKQSKDLKQKGDLLTLNPLANSLYLHLAASKDFTKAYISLQKLFGTFNSSSNTKIDNKTFLRLIDLTCAIIPFPNHEKLKLLNKFNSIDRINEVNRMLESMIQVFYNLKKNNKIINHWFYNEATNIQRANVVASQLKSIRLILEGMTNKPDKDIKTNQSPPRQLVRRGNNNKPAKSPMSDDGNESNDEYDDDEDDDDDEDELKAITSFIKGKLPNISTLSSDTKRLIVKDFKRIKSSPPGNSDFHVIRNYLEIVADIPWDRYVTRFKSNKDIDLEFAKKQLDSDHYGLQHVKTRLIQYLVVLKLLGINAEKEFEKIESENSKKSKKNESSSGSMGKNDKQRSEKTFTRSDDSIVIANNDETSIAHETARNKNKKSKSLTTIEKSSLNKSLMVSKNNKSPIIMLVGPPGTGKTSLAKSIAKSLGRNFQRVSLGGIKDESEIRGHRRTYVGAMPGVIIQSLRKSRSMNPVILLDEIDKIIGGNNGVNKFNGDPSAALLEVLDPEQNTSFIDHYLGFPVDLSQVMFICTANEASNLSRPLLDRLEMIEVGAYDYDEKLVIGERYLLPRQIKRNGIPNADLIDVDKSVMQKVILDYTREAGVRNFERSLGRICRFKAVEYSQSLEKLSEYQPKVEIEDLPKYLGLPFANLSTELFESPIESAKCGVVNGLSYNSDGSGSVLVFESIGFNHEGKSGSSSLNMTGRLGDVLMESAKIGLTFIKSIIYKNLLNLSDRNLSENLIDKINNMEIHLHVPSGSIQKDGPSAGITVALSFLSLILEKPVPLDVAMTGEITLRGLVLPIGGIKEKILGAHLNGIKRVIVPRENRKDLIEEYCRSTNDFNQLNDLLLDNENKYNFKRCEPEKFWFDKYGITIHYAREFWDVIKAVWGDALLVKVEQARMVEYHL