Protein
Succinate dehydrogenase assembly factor 2, mitochondrial
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Similarity
Belongs to the SDHAF2 family.
Sequence
MFRNIQKRNISSSGRVLLNHGKPQNPVYNAELTMKIEPIQRTGESIDVKRARLVYQSRKRGILESDLLLSRFAKRYLSGFSQEELDEYDKLLDEPDWDIYYWATKNYDVTPLPDKWKNSKILKLLQEDAENKEKEILRMPEL