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DEFB1

Gene
Defb1
Protein
Beta-defensin 1
Organism
Mus musculus
Length
69 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.749 kDa
Sequence
MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS

Gene
Defb1
Protein
Beta-defensin 1
Organism
Rattus norvegicus
Length
69 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.837 kDa
Sequence
MKTHYFLLVMLFFLFSQMELGAGILTSLGRRTDQYRCLQNGGFCLRSSCPSHTKLQGTCKPDKPNCCRS

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Allochrocebus preussi
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.544 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Cercopithecus erythrogaster
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.543 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYICVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Chlorocebus aethiops
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.544 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Gorilla gorilla gorilla
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.303 kDa
Sequence
MRTSYLLLFTLCLLLSEIASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYGGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Homo sapiens
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Similarity
Belongs to the beta-defensin family.
Mass
7.42 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Hylobates lar
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.535 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYQGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Hylobates moloch
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.535 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYQGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Macaca fascicularis
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.572 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTRIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Macaca mulatta
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.572 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTRIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Nomascus concolor
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.535 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYQGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Pan troglodytes
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.321 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYGGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Papio anubis
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.572 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTRIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Pongo pygmaeus
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.42 kDa
Sequence
MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Presbytis melalophos
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.562 kDa
Sequence
MRTSYLLLFTLCLLMSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Saguinus oedipus
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.423 kDa
Sequence
MRTSYLLLFILCLVLCDMDSGDTFLTGLGHRSDHYNCVKGGGQCLYSACPIYTKVQGTCYGGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Trachypithecus cristatus
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.562 kDa
Sequence
MRTSYLLLFTLCLLMSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Trachypithecus obscurus
Length
68 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.562 kDa
Sequence
MRTSYLLLFTLCLLMSEMASGDNFLTGLGHRSDHYNCVRSGGQCLYSACPIYTKIQGTCYHGKAKCCK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Chinchilla lanigera
Length
67 amino acids
Function
Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear (PubMed:14996845). May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).
Similarity
Belongs to the beta-defensin family.
Mass
7.676 kDa
Sequence
MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Capra hircus
Length
64 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.258 kDa
Sequence
MRLHHLLLVLFFLVLSAGSGFTQGIRSRRSCHRNKGVCALTRCPRNMRQIGTCFGPPVKCCRKK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Sus scrofa
Length
64 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.066 kDa
Sequence
MRLHRLLLVFLLMVLLPVPGLLKNIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Ovis aries
Length
64 amino acids
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Similarity
Belongs to the beta-defensin family.
Mass
7.244 kDa
Sequence
MRLHHLLLVLFFVVLSAGSGFTQGVRNRLSCHRNKGVCVPSRCPRHMRQIGTCRGPPVKCCRKK

Gene
DEFB1
Protein
Beta-defensin 1
Organism
Bos taurus
Length
38 amino acids
Function
Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A (PubMed:8454635). May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity).
Similarity
Belongs to the beta-defensin family.
Mass
4.278 kDa
Sequence
DFASCHTNGGICLPNRCPGHMIQIGICFRPRVKCCRSW