Protein
VPS74-like protein DDB_G0288371
Organism
Dictyostelium discoideum
Function
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. May be involved in vacuolar protein sorting (By similarity).
Similarity
Belongs to the GOLPH3/VPS74 family.
Sequence
MNPDNDNDSLPLLTLPEQLFLLILNPETGKLPYTFVPLFHGFVGCGIAELQLMDKVIVTKQNSQSFNNNKMLIKVIDHSKTGDTFLDYILSKLSNSFAQKGLQMATAILTISVGLNKMKRITETIAQSLIKKGFIRGTLKRSVLFKNKSIYEVIDYQAKLSVESSICKVLSTPPDYPDNCLRELIILLTFKQYEDFLIKPKLMDSLISRLYHPEQCAHIKANLRLINKNFYKEPSEVHLTNDPSVKMLSLVIGGIRNAITSE