Protein
NuA4 complex subunit EAF3 homolog
Organism
Dictyostelium discoideum
Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Also component of a complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
Sequence
MDETYEENEKVLVHHQNRIYEAKIIKVDPKTSKSDKKKPLYFIHYLGWKEKWNEWIEPNKILKYTDKNRELQKRTNIKASTTSLNNKKNTKKAKEVKQQQQQQQPIAYDSENSDEDENESELEDGGGEDADEGGEDIEDQENNNNNDTGGEEADDNNTSPRSTGSSSSSSSSKSNNNNNNNNNNNNNNNNNNNNNNNNNNKRKRNDSKSSHFQSTKFIDIEIPLSLKNKLVDDWNSINNEKSILSLPKSPNVKDILNKIIEENDKSSECKEVINGIKQYFNKALGTLLLYKFERPQYDSILKTNPKKSMSDIYGAEHLLRLFVKLPQLLVISNLEEKTITQLKDAFEIVLEYLEKNSSTLFLKEYTIASSPYLKAASSN