DDB2

Protein DAMAGED DNA-BINDING 2

557 amino acids

May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:18551167). Involved in UV-B tolerance and genome integrity. In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions (PubMed:20128879).

Belongs to the WD repeat DDB2/WDR76 family.

62.829 kDa

MSSTRSRRKRDPEIVIARDTDSELSSSEEEEEEEDNYPFSESEEEDEAVKNGGKIELEKNKAKGKAPITVKLIKKVCKVCKQPGHEAGFKGATYIDCPMKPCFLCKMPGHTTMSCPHRVVTDHGILPTSHRNTKNPIDFVFKRQLQPRIPPIKPKYVIPDQVHCAVIRYHSRRVTCLEFHPTKNNILLSGDKKGQIGVWDFGKVYEKNVYGNIHSVQVNNMRFSPTNDDMVYSASSDGTIGYTDLETGTSSTLLNLNPDGWQGANSWKMLYGMDINSEKGVVLAADNFGFLHMIDHRTNNSTGEPILIHKQGSKVCGLDCNPVQPELLLSCGNDHFARIWDMRKLQPKASLHDLAHKRVVNSAYFSPSSGTKILTTCQDNRIRIWDSIFGNLDLPSREIVHSNDFNRHLTPFKAEWDPKDTSESLIVIGRYISENYNGTALHPIDFIDASNGQLVAEVMDPNITTITPVNKLHPRDDVLASGSSRSLFIWRPQDNTEMVEEKKDKKIIICYGDSKKKGKKQKRGSDDEDDEDDIFSSKGKNIKVNKYQAKTTKKTKT

DDB2

DNA damage-binding protein 2

426 amino acids

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity).

Belongs to the WD repeat DDB2/WDR76 family.

47.591 kDa

MAPRKRPENQKTPEVVVRPKSKRNRSPRELEPEAKKLCVKGPGSSRRFDSGLWAGLASLRVPPLCSSIVRALHQHKLGTAAWPSLQQGLQQSFLNSLASYRIFQKAAPFDRRATSLAWHPTHPSTLAVGSKGGDILLWNFGIKDKPTFIKGIGAGGSITGMKFNPLNTNQFFTSSMEGTTRLQDFKGNTLRVFASSDTCNVWFCSLDVSVKSRVVVTGDNVGHVILLNMDGRELWNLRMHKKKVTHVALNPCCDWLLATASVDQTVKIWDLRQVRGKSSFLHSLPHRHPVNAAHFSPDGAQLLTTDQKSEIRVYSACQWDCPPSLIPHPHRHFQHLTPIKASWHPRYNLIVVGRYPDPNFKSCSPHELRTIDVFDGSSGKIMYQLYDPESSGIMSLNEFNPMGDTLASVMGYHILVWSPEDAGTQK