Protein
Dicer-like protein 2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.
Similarity
Belongs to the helicase family. Dicer subfamily.
Sequence
MDQDPRKDNPVEMDVDRDDSSQDPDDNESFKSALDEPLDLKELYQDALEKPSEEPSEELNDQVSTPAALTARAYQLEMFEASLKQNIIVALFSDRVMVADGHWQWQDSGRIWFLTPTVALARQQHRVLQSQIPSVKAIMLCGQDGVDSWSEQAVWDAVLLNVRIVVSTYQILFDANAHSFVRLDSLSLIVIDEAHNCSGSHPIARLMTEAYLPAKKAGLPVPSILGLTASPLKSNNLADIEKLEQVLDAVCRTPTIHREELLAHVNRPEMLVVSYGDSGTDPTPTDLMTRFLEAYHRLDISKDPDVLLLKAQRTERAREKLRQMITKKDTLAQKELRGVYNRALLVRREIGPWAADYYLTRTVSHMLAELERGEPPAQHRYIGEALRSIPIPAISKEPIQLSPKVQTLLKVLASHQQDPVGIVFVKERVMVSIVTHIISTHPLTKDRYRTASMIGTASVPGKARNHMDMTKKEDMTSLEGFRLGRFNLLVATSVLEEGIDVPICNLVICFDEPSNIKSFIQRRGRAREVSSTLYLMVQNASSESATDWHNLERLMKERYEDEMRQNAELELLDDPRIGSYPVLEVESTGARMTIRDARSHLNHFCAKVSSRSRYLQKEPYFVIRQVNPDPASPGRRTLLQATVHLPASLAPDLRRHESLWTWTSEKLAIMDASFQAYKALYNAGLVNENLLPTKVSDFLADLGDDPGHIWVKTQFDPWPEVAYAWQESSSLYSRRLTVLVPGVENPLEFEFILPVPVPYMAPLKLWWNATSALTLITSPEMQEFRKQEGTSAGPDHSYALLAMAFAHRFPIQGRQYPIRLVSTRRKLDVDGIAALEFDPRLYESSPQPPLVRLVDGRNMPYFVTKILPSKPPVELISKPSTDHADLPENVPYVVCKPIGKAVGQFIPLDAAQDQDSWTPKNGKLYRKVLPSTQIRMDNFPAVFAQVGAVIPAFTRAVEMSLVAADLMYNRLGCLQLDNLPLITTALISSGSRGPTNYERLEFIGDTILKFCACLTASALFPNHHERLLSQWKDKLVNNVRLCRASRDFGLDEYIINSAASKKWRPKFVEDYMDEMKSPISAETRQMSSKMVADVVESLIGAAYMCGGMSKALECVALLLPTPKSSQFKWQEIELSRTQLFEFAPKDAILSKQLEPLEKAMDYTFNKKSLLIEAMTHPSCAGLGTNESCYERLEFLGDAILDVIVVKRLMAETGPNELAHNDMHEHLSSVVTADIMAFLAMEWVIMQTDINEIDPTNLDALGLLPSSQSRITPASLVSNKEDWPFWRFMRHNSPQVGATQTATIERYLTLRDEIRDAIWKHNTLPWALLARMGPQKFYSDIVESLIGAVWVDSGSWKACEDVLTQMGLLPLLDHLLETKAHVMHPNVELQILAPPNKRATRTEFVIISNKRGIISSGTEFLDEPSAVDDGLVSVEPYDDTPEHDEVFSCKLFVGGKQVADVTGAATKEEARVRAAEKGCLVIKAERKVWNEAKAAAKEDKGHNTENGDANADNGQSGEKEEVPDCRDADGDTVMN