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DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
343 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
Similarity
Belongs to the DASH complex DAM1 family.
Mass
38.422 kDa
Sequence
MSEDKAKLGTTRSATEYRLSIGSAPTSRRSSMGESSSLMKFADQEGLTSSVGEYNENTIQQLLLPKIRELSDSIITLDSNFTRLNFIHESLADLNESLGSLLYGIMSNSWCVEFSQAPHDIQDDLIAIKQLKSLEDEKNNLVMELSNMERGIKRKKDEQGENDLAKASQNKQFNQPLFPSSQVRKYRSYDNRDKRKPSKIGNNLQVENEEDYEDDTSSEASFVLNPTNIGMSKSSQGHVTKTTRLNNNTNSKLRRKSILHTIRNSIASGADLPIENDNVVNLGDLHPNNRISLGSGAARVVNGPVTKNRNSMFSGRAERKPTESRHSVAKKTEKKINTRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
343 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids.
Similarity
Belongs to the DASH complex DAM1 family.
Mass
38.422 kDa
Sequence
MSEDKAKLGTTRSATEYRLSIGSAPTSRRSSMGESSSLMKFADQEGLTSSVGEYNENTIQQLLLPKIRELSDSIITLDSNFTRLNFIHESLADLNESLGSLLYGIMSNSWCVEFSQAPHDIQDDLIAIKQLKSLEDEKNNLVMELSNMERGIKRKKDEQGENDLAKASQNKQFNQPLFPSSQVRKYRSYDNRDKRKPSKIGNNLQVENEEDYEDDTSSEASFVLNPTNIGMSKSSQGHVTKTTRLNNNTNSKLRRKSILHTIRNSIASGADLPIENDNVVNLGDLHPNNRISLGSGAARVVNGPVTKNRNSMFSGRAERKPTESRHSVAKKTEKKINTRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
339 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
36.698 kDa
Sequence
MSKESVRESKAATEYRLSISSNPGSRRSSFGGSSEHPAGSGIGNNKASNGELREATLVDTLLLPQVQELKDSMITLDANLTHMNFIHESLVDLNESVSALLYGLMCNSWCVDFPNMPHHTARELGISKELARLKEEKQQLLADLQGTAQAPSLVLKEKEPNTSKQKFQLPKPPMVSTRSVVAPVRTISEEEEDDNTAASFVSNPTVMGQPPHAPPPVARSNNAKGRRRYSILQQIRNHDLTGQKHMVANLGGTVKARAATHPIPESAGEKRKSLAVSAVRIGNNKRLQTSRPPSGGRDVTMARKRSGTQPAILNTNSITHSSTGAVPASSAQGRRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
313 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
34.528 kDa
Sequence
MSQRPNTPQRDRPTEYRLSLSSNASSRRSSLGNNGRDQHASNQTMIEKYVLPQLQELSDSMVTLDGNMTHMNFIHESIADLNEALSALLYGLMCNSWCVDFPNISHDTPHELKLIQRLEELKQERQALQAKLKPKELTKGSILPLSRQPLSRGSQMLYRDENVPGSTASSNVNIDINDDEDNTAASFVSNPTTFKPQMISSVGASTDFMGKQTVGSASSKLRRRSILHQIRNNAAIGTIPNTLTGITPGERKRSLAVSAKRIPILAGSSTTAGSASSANRESTNTEPALPNRVVRTRQRTYNPKNLASRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
313 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
34.528 kDa
Sequence
MSQRPNTPQRDRPTEYRLSLSSNASSRRSSLGNNGRDQHASNQTMIEKYVLPQLQELSDSMVTLDGNMTHMNFIHESIADLNEALSALLYGLMCNSWCVDFPNISHDTPHELKLIQRLEELKQERQALQAKLKPKELTKGSILPLSRQPLSRGSQMLYRDENVPGSTASSNVNIDINDDEDNTAASFVSNPTTFKPQMISSVGASTDFMGKQTVGSASSKLRRRSILHQIRNNAAIGTIPNTLTGITPGERKRSLAVSAKRIPILAGSSTTAGSASSANRESTNTEPALPNRVVRTRQRTYNPKNLASRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
307 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
34.876 kDa
Sequence
MSQDIRKEDGVRSATEYKLSMSSNPGSRRSSMADAESFNDDNMVLKNDVLREYLLPQIKDLTDSVVTLDSNMTRLNFIHDNLVDLNESFGSLLYGLMCNSWCVEFPNAPTRFDKEIRLMNEIEELSAEKSKLKSRLNSLREKPNAQTSDEKMKKPSGISQPIFQKPNVRRPRNALNDENLHKFNRENPPVYDDKREADEDTNSEASFVSNPANSKDMQLFANGSSNNDPKSRLRRKSILHTIRNSIASTSDAYDRKKQQGIQMGRVSLGGGAARVVSGRNMFEQQRTTRHSTTGIPNRVVKKRPPFK
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
307 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
34.876 kDa
Sequence
MSQDIRKEDGVRSATEYKLSMSSNPGSRRSSMADAESFNDDNMVLKNDVLREYLLPQIKDLTDSVVTLDSNMTRLNFIHDNLVDLNESFGSLLYGLMCNSWCVEFPNAPTRFDKEIRLMNEIEELSAEKSKLKSRLNSLREKPNAQTSDEKMKKPSGISQPIFQKPNVRRPRNALNDENLHKFNRENPPVYDDKREADEDTNSEASFVSNPANSKDMQLFANGSSNNDPKSRLRRKSILHTIRNSIASTSDAYDRKKQQGIQMGRVSLGGGAARVVSGRNMFEQQRTTRHSTTGIPNRVVKKRPPFK
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
294 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
33.059 kDa
Sequence
MASSPRPTTPNSQKKRSGRRQSHRSSGAYNILPQSPKIHYPVDPDNLPLEAPGNTEKFESLSDALEELDVNMTNLQSIHEAISDGFNESFASFLYGLSITMWCVDFPGCPSRNQWEKLKLVEGLDDRISELAEKIRSHREENERLKNRLASNVVESTEEVENHSDSHENRKPQHSHRVGKGPTRQVDEGDDTYMTNEGSFVVNPSAPSATRIPQPVKTAPRRFTKHTPPPPPPPPPADTSMHSSYRGPNLNQPPRYMRGLFDSTNRPTTPSNNRSKRVANPNRIQKATGRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
294 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
33.059 kDa
Sequence
MASSPRPTTPNSQKKRSGRRQSHRSSGAYNILPQSPKIHYPVDPDNLPLEAPGNTEKFESLSDALEELDVNMTNLQSIHEAISDGFNESFASFLYGLSITMWCVDFPGCPSRNQWEKLKLVEGLDDRISELAEKIRSHREENERLKNRLASNVVESTEEVENHSDSHENRKPQHSHRVGKGPTRQVDEGDDTYMTNEGSFVVNPSAPSATRIPQPVKTAPRRFTKHTPPPPPPPPPADTSMHSSYRGPNLNQPPRYMRGLFDSTNRPTTPSNNRSKRVANPNRIQKATGRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
277 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
31.906 kDa
Sequence
MSSSKPVTPRNDRRQNSGRRHSHRSSGIQLPSMSPKVHHYPIDAENLPMDSPEIVEKFASLAESMETLDLHMHDLCHIHDHISNQFNESFASFLYGLSMTMWCVDFPGCPSREQWEALISKRERKERIEVLKKRLADAQKLNDRLKLRLSDEAKQKPQQLTSQQRPTHGPTRQIKQQPRSVNFNTHSSDSISTNSYTSGDFNTNRRVSRIPQPSRSNLPSSRFQAPSKSGPNLNQPPRYMRGLFDGNNTLNTSNYSRIKKPIHNRSVNNLQNRPPFR
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
223 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
25.253 kDa
Sequence
MQRPTTPLRRSNSRQSDHEEHYPIVESVLDMAIGEQMAELADGMSALDRNLKDLQVIHTNLNNFNESFSTLIYGLQMNAWCAEFHNGPRSCDFARRKEVEEMEERARRAQMQAERDRMAMQQIQETPTRLPSEPSDGDVTYMRNDNSFIIQPPSSYQSQLPSRIPQSSRASRIRPPNSLRPPRGRGLYLRGGSRGVTGGRGSYTGVGRGSGRPASEGTTRRWL
Protein
DASH complex subunit DAM1: DAM1

Gene
DAM1
Protein
DASH complex subunit DAM1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
223 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
Similarity
Belongs to the DASH complex DAM1 family.
Mass
25.253 kDa
Sequence
MQRPTTPLRRSNSRQSDHEEHYPIVESVLDMAIGEQMAELADGMSALDRNLKDLQVIHTNLNNFNESFSTLIYGLQMNAWCAEFHNGPRSCDFARRKEVEEMEERARRAQMQAERDRMAMQQIQETPTRLPSEPSDGDVTYMRNDNSFIIQPPSSYQSQLPSRIPQSSRASRIRPPNSLRPPRGRGLYLRGGSRGVTGGRGSYTGVGRGSGRPASEGTTRRWL
Protein
DASH complex subunit DAM1: DAM1

Gene
dam1
Protein
DASH complex subunit dam1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
155 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.
Similarity
Belongs to the DASH complex DAM1 family.
Mass
17.444 kDa
Sequence
MEKYQKATQNPLENVDNVKIESENAIPSNLQAFTKSLAVLDDNVSEFRKRMNHLSATKQILDNFNESFSSFLYGLQINAFCVDYENAPLSESFLLQAKKDQFKATLMTRTGHSISDPPYDGGVISHDPNFATADETFATNDTSFIERPETYSASR
Protein
DASH complex subunit dam1: dam1

Gene
dam1
Protein
DASH complex subunit dam1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
155 amino acids
Function
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.
Similarity
Belongs to the DASH complex DAM1 family.
Mass
17.444 kDa
Sequence
MEKYQKATQNPLENVDNVKIESENAIPSNLQAFTKSLAVLDDNVSEFRKRMNHLSATKQILDNFNESFSSFLYGLQINAFCVDYENAPLSESFLLQAKKDQFKATLMTRTGHSISDPPYDGGVISHDPNFATADETFATNDTSFIERPETYSASR
Protein
DASH complex subunit dam1: dam1