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D9R

Gene
D9R
Protein
mRNA-decapping protein D9
Organism
Vaccinia virus (strain Copenhagen)
Length
213 amino acids
Function
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis. Does not cleave unmethylated RNAs or RNAs shorter than 24 nucleotides (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
25.024 kDa
Sequence
MGITMDEEVIFETPRELISIKRIKDIPRSKDTHVFAACITSDGYPLIGARRTSFAFQAILSQQNSDSIFRVSTKLLRFMYYNELREIFRRLRKGSINNIDPHFEELILLGGKLDKKESIKDCLRRELKEESDERITVKEFGNVILKLTTRDKLFNKVYISYCMACFINQSLEDLSHTSIYNVEIRKIKSLNDCINDDKYEYLSYIYNMLVNSK

Gene
D9R
Protein
mRNA-decapping protein D9
Organism
Variola virus (isolate Human/India/Ind3/1967)
Length
213 amino acids
Function
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis. Does not cleave unmethylated RNAs or RNAs shorter than 24 nucleotides (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
24.982 kDa
Sequence
MGITMDEEVIFETPRELISIKRIKDIPRSKDTHVFAACITSDGYPLIGARRTSFAFQAILSQQNSDSIFRVSTKLLRFMYYNELREIFRRLRKGSINNIDPHFEELILLGGKLDKKESIKDCLRRELKEESDERITVKEFGNVILKLTTQDKLFNKVYIGYCMSCFINQSLEDLSHTSIYNVEIRKIKSLNDCINDDKYEYLSYIYNMLVNSK

Gene
D9R
Protein
mRNA-decapping protein D9
Organism
Rabbit fibroma virus (strain Kasza)
Length
206 amino acids
Function
Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis. Does not cleave unmethylated RNAs or RNAs shorter than 24 nucleotides (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
24.03 kDa
Sequence
MTTFETPRETVFIESVDSIPQSKKTHVFAICVTVDNKPIVAARRSSFVFQEITMNMNPPIVVTISKHLTNYMYNNEIKEIKRKLQKGSAPIYKTSFEELILLGGKLNKSETIDDCIRREIKEETDSKLTIKSIGTTCVKITITDKLFNRKYVNYCKLCYIDELMEEVISFVIYNVEIRKLKSLLDCDNNDKFNYLRFIYNTLLYSK