Protein
D-galactonate dehydratase family member Cbei_4837
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
Function
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Similarity
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Sequence
MEPTIITDVLCYITKPDRHNLVVVKVETNKGIYGLGCATFQQRPKAVSLVVSEYLKPILIGRDANNIEDLWQMMMVNSYWRNGPILNNAISGVDMALWDIKGKLANMPLYQLFGGKSRDAIAAYTHAVADNLEDLYTEIDEIRKKGYQHIRCQLGFYGGNSSEFHTTDNPTQGSYFDQDEYMRTTVSMFSSLREKYGYKFHILHDVHERLFPNQAVQFAKDVEKYKPYFIEDILPPDQNEWLGQIRSQTSTPLATGELFNNPMEWKSLIANRQVDFIRCHVSQIGGITPALKLGSLCAAFGVRIAWHTPSDITPIGVAVNIHLNINLHNAAIQENIEINDNTRCVFSGIPEAKNGFFYPIESPGIGVDIDENEIIKYPVEYRPHEWTQSRIPDGTIVTP